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Rabies immune globulin, human Side Effects

For the Consumer

Applies to rabies immune globulin, human: intramuscular solution

As well as its needed effects, rabies immune globulin, human may cause unwanted side effects that require medical attention.

Major Side Effects

If any of the following side effects occur while taking rabies immune globulin, human, check with your doctor immediately:

  • Cloudy or bloody urine
  • high blood pressure
  • large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
  • swelling of the face, feet, or lower legs

Minor Side Effects

Some rabies immune globulin, human side effects may not need any medical attention. As your body gets used to the medicine these side effects may disappear. Your health care professional may be able to help you prevent or reduce these side effects, but do check with them if any of the following side effects continue, or if you are concerned about them:

Less common:
  • Fever
  • pain, soreness, tenderness, or stiffness at the injection site
  • Skin rash

For Healthcare Professionals

Applies to rabies immune globulin, human: intramuscular solution


The most common adverse events were injection site and skin reactions.[Ref]


Rare (less than 0.1%): Injection site: swelling, pain, erythema, induration, warmth, pruritus, rash
Frequency not reported: Discomfort at injection site, soreness at injection site[Ref]


Rare (less than 0.1%): Skin reaction, erythema, pruritus, skin rash
Frequency not reported: Angioneurotic edema, bruising[Ref]


Rare (less than 0.1%): Hypersensitivity, anaphylactic shock, allergic type reactions[Ref]


Rare (less than 0.1%): Fever, malaise, chill, fatigue, influenza like illness
Frequency not reported: Mild temperature elevations, disabling pain that limited motion[Ref]


Rare (less than 0.1%): Nephrotic syndrome[Ref]


Rare (less than 0.1%): Tachycardia, hypotension[Ref]


Rare (less than 0.1%): Arthralgia
Frequency not reported: Compartment syndrome, infiltration of wounds[Ref]


Rare (less than 0.1%): Nausea, vomiting[Ref]

Nervous system

Rare (less than 0.1%): Headache[Ref]


Frequency not reported: Sensitization to repeated injections[Ref]


1. "Product Information. Imogam Rabies-HT (rabies immune globulin, human)." sanofi pasteur, Swiftwater, PA.

2. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0

3. "Product Information. Hyperrab S/D (rabies immune globulin, human)." Grifols Therapeutics, Clayton, NC.

4. Cerner Multum, Inc. "Australian Product Information." O 0

It is possible that some side effects of rabies immune globulin, human may not have been reported. These can be reported to the FDA here. Always consult a healthcare professional for medical advice.

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