Prostin E2 Side Effects
Generic Name: dinoprostone topical
Note: This page contains side effects data for the generic drug dinoprostone topical. It is possible that some of the dosage forms included below may not apply to the brand name Prostin E2.
For the Consumer
Applies to dinoprostone topical: vaginal gel/jelly, vaginal insert extended release, vaginal suppository, vaginal tampon
As well as its needed effects, dinoprostone topical (the active ingredient contained in Prostin E2) may cause unwanted side effects that require medical attention.
Major Side Effects
If any of the following side effects occur while taking dinoprostone topical, check with your doctor immediately:Less common or rare:
- Fast or slow heartbeat
- increased pain of the uterus
- pale, cool, blotchy skin on arms or legs
- pressing or painful feeling in chest
- shortness of breath
- swelling of face, inside the nose, and eyelids
- tightness in chest
- trouble in breathing
- weak or absent pulse in arms or legs
Minor Side Effects
Some dinoprostone topical side effects may not need any medical attention. As your body gets used to the medicine these side effects may disappear. Your health care professional may be able to help you prevent or reduce these side effects, but do check with them if any of the following side effects continue, or if you are concerned about them:More common:
- Abdominal or stomach cramps
- Chills or shivering
- swelling of the genital area (vulva)
- tender or mildly bloated abdomen or stomach
This procedure may still result in some effects, which occur after the procedure is completed, that need medical attention. Check with your doctor if any of the following side effects occur while taking dinoprostone topical:
- Chills or shivering (continuing)
- fever (continuing)
- foul-smelling vaginal discharge
- pain in lower abdomen
- unusual increase in bleeding of the uterus
For Healthcare Professionals
Applies to dinoprostone topical: vaginal gel, vaginal insert, vaginal suppository
Uncommon (0.1% to 1%): Nausea, vomiting, diarrhea, abdominal pain[Ref]
Very common (10% or more): Any fetal heart rate abnormality
Frequency not reported: Hearing impairment, neonatal distress, neonatal death, stillbirths, low Apgar score[Ref]
Common (1% to 10%): Hypotension, bradycardia
Frequency not reported: Flushing or hot flashes, chest pain, cardiac arrhythmia[Ref]
Uncommon (0.1% to 1%): Fever
Frequency not reported: Headache, dizziness, weakness, tremor, paresthesia[Ref]
Rare (0.01% to 0.1%): Postpartum disseminated intravascular coagulation
Frequency not reported: Elevated WBC[Ref]
Frequency not reported: Dehydration[Ref]
Frequency not reported: Back pain, joint inflammation or pain new or exacerbated, muscle cramp or pain, nocturnal leg cramps[Ref]
Frequency not reported: Dyspnea, coughing, pharyngitis, laryngitis, wheezing, tightness in chest, pharyngitis, laryngitis[Ref]
Frequency not reported: Rash, diaphoresis, skin discoloration[Ref]
Frequency not reported: Blurred vision, eye pain[Ref]
Frequency not reported: Anaphylactic reactions (including anaphylactic shock)[Ref]
Common (1% to 10%): Uterine hyperstimulation (with or without fetal distress), fetal distress without uterine hyperstimulation, warm feeling in vagina
Frequency not reported: Uterine hypertonus, uterine rupture, placenta abruptio, rapid cervical dilatation, vaginal pain, vaginal irritation, vaginitis or vulvitis, breast tenderness, vaginismus, genital edema, transient vasovagal symptoms (flushing, shivering, headache, dizziness)[Ref]
Frequency not reported: Tension[Ref]
1. "Product Information. Cervidil (dinoprostone topical)." Forest Pharmaceuticals, St. Louis, MO.
2. "Product Information. Prostin E2 Suppository (dinoprostone topical)." Pharmacia and Upjohn, Kalamazoo, MI.
3. Cerner Multum, Inc. "Australian Product Information." O 0
4. "Product Information. Prepidil (dinoprostone topical)" Pharmacia and Upjohn, Kalamazoo, MI.
5. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
It is possible that some side effects of Prostin E2 may not have been reported. These can be reported to the FDA here. Always consult a healthcare professional for medical advice.
More about Prostin E2 (dinoprostone topical)
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