Prostin E2 Side Effects
Generic name: dinoprostone topical
Medically reviewed by Drugs.com. Last updated on Jun 29, 2024.
Note: This document provides detailed information about Prostin E2 Side Effects associated with dinoprostone topical. Some dosage forms listed on this page may not apply specifically to the brand name Prostin E2.
Applies to dinoprostone topical: vaginal gel/jelly, vaginal insert extended release.
Important warnings
This medicine can cause some serious health issues
Vaginal route (suppository)
Dinoprostone should be used with strict adherence to recommended dosages and only by medically trained personnel in a hospital setting that can provide immediate intensive care and acute surgical facilities.
Common side effects of Prostin E2
Some side effects of dinoprostone topical may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.
Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
Less common or rare side effects
- chills or shivering
- constipation
- flushing
- headache
- swelling of the genital area (vulva)
- tender or mildly bloated abdomen or stomach
This procedure may still result in some effects, which occur after the procedure is completed, that need medical attention. Check with your doctor if any of the following side effects occur while taking dinoprostone topical:
- chills or shivering (continuing)
- fever (continuing)
- foul-smelling vaginal discharge
- pain in lower abdomen
- unusual increase in bleeding of the uterus
Serious side effects of Prostin E2
Along with its needed effects, dinoprostone topical (the active ingredient contained in Prostin E2) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur while taking dinoprostone topical:
Less common or rare side effects
- fast or slow heartbeat
- hives
- increased pain of the uterus
- pale, cool, blotchy skin on arms or legs
- pressing or painful feeling in chest
- shortness of breath
- swelling of face, inside the nose, and eyelids
- tightness in chest
- trouble in breathing
- weak or absent pulse in arms or legs
- wheezing
For healthcare professionals
Applies to dinoprostone topical: vaginal gel, vaginal insert, vaginal suppository.
Gastrointestinal adverse events
- Uncommon (0.1% to 1%): Nausea, vomiting, diarrhea, abdominal pain[Ref]
Other
- Very common (10% or more): Any fetal heart rate abnormality
- Frequency not reported: Hearing impairment, neonatal distress, neonatal death, stillbirths, low Apgar score[Ref]
Cardiovascular
- Common (1% to 10%): Hypotension, bradycardia
- Frequency not reported: Flushing or hot flashes, chest pain, cardiac arrhythmia[Ref]
Nervous system
- Uncommon (0.1% to 1%): Fever
- Frequency not reported: Headache, dizziness, weakness, tremor, paresthesia[Ref]
Hematologic
- Rare (0.01% to 0.1%): Postpartum disseminated intravascular coagulation
- Frequency not reported: Elevated WBC[Ref]
Metabolic
- Frequency not reported: Dehydration[Ref]
Musculoskeletal
- Frequency not reported: Back pain, joint inflammation or pain new or exacerbated, muscle cramp or pain, nocturnal leg cramps[Ref]
Respiratory
- Frequency not reported: Dyspnea, coughing, pharyngitis, laryngitis, wheezing, tightness in chest, pharyngitis, laryngitis[Ref]
Dermatologic
- Frequency not reported: Rash, diaphoresis, skin discoloration[Ref]
Ocular
- Frequency not reported: Blurred vision, eye pain[Ref]
Hypersensitivity
- Frequency not reported: Anaphylactic reactions (including anaphylactic shock)[Ref]
Genitourinary
- Common (1% to 10%): Uterine hyperstimulation (with or without fetal distress), fetal distress without uterine hyperstimulation, warm feeling in vagina
- Frequency not reported: Uterine hypertonus, uterine rupture, placenta abruptio, rapid cervical dilatation, vaginal pain, vaginal irritation, vaginitis or vulvitis, breast tenderness, vaginismus, genital edema, transient vasovagal symptoms (flushing, shivering, headache, dizziness)[Ref]
Psychiatric
- Frequency not reported: Tension[Ref]
References
1. (2022) "Product Information. Prostin E2 (dinoprostone topical)." Apothecon Inc
2. (2001) "Product Information. Prepidil (dinoprostone topical)." Pharmacia and Upjohn
3. (2002) "Product Information. Cervidil (dinoprostone topical)." Forest Pharmaceuticals
4. Cerner Multum, Inc. "UK Summary of Product Characteristics."
5. Cerner Multum, Inc. "Australian Product Information."
More about Prostin E2 (dinoprostone topical)
- Check interactions
- Compare alternatives
- Dosage information
- During pregnancy
- Drug class: uterotonic agents
- Breastfeeding
Patient resources
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Further information
Prostin E2 side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following this guide.