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Polytrim Side Effects

Generic name: polymyxin b/trimethoprim ophthalmic

Medically reviewed by Last updated on Jan 8, 2023.

Note: This document contains side effect information about polymyxin b/trimethoprim ophthalmic. Some dosage forms listed on this page may not apply to the brand name Polytrim.

Applies to polymyxin b/trimethoprim ophthalmic: ophthalmic solution.

Serious side effects of Polytrim

Along with its needed effects, polymyxin b/trimethoprim ophthalmic may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking polymyxin b/trimethoprim ophthalmic:

More common

  • Increased redness, burning, stinging, or itching of the eye

Incidence not known

  • Blurred vision
  • change in color vision
  • difficulty seeing at night
  • increased sensitivity of the eyes to sunlight
  • increased tearing
  • rash around the eye
  • swelling of the eyelid

For Healthcare Professionals

Applies to polymyxin b/trimethoprim ophthalmic: ophthalmic solution.


Ocular side effects are the most common, and include local irritation, increased redness, burning, stinging, and/or itching. This may occur on instillation, within 48 hours, or at any time with extended use.[Ref]


Hypersensitivity reactions have included lid edema, itching, increased redness, tearing, and/or circumocular rash.[Ref]


Dermatologic side effects associated with oral trimethoprim have included photosensitivity.[Ref]


1. "Product Information. Polytrim (polymyxin B-trimethoprim ophthalmic)." Allergan Inc (2022):

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.