Panretin Side Effects

Generic name: alitretinoin topical

Medically reviewed by Drugs.com. Last updated on Jul 13, 2024.

Note: This document provides detailed information about Panretin.

Applies to alitretinoin topical: topical gel/jelly Side Effects associated with alitretinoin topical. Some dosage forms listed on this page may not apply specifically to the brand name Panretin.

Applies to alitretinoin topical: topical gel/jelly.

Precautions

It is very important that your doctor check your progress at regular visits to make sure that this medicine is working properly and to check for unwanted effects.

This medicine increases the sensitivity of the treated areas of your skin to sunlight or sun lamps. Therefore, exposure to the sun, even through window glass or on a cloudy day, could cause a serious burn.

Avoid application of the gel to normal skin surrounding the lesions or to mucous membranes

Serious side effects of Panretin

Along with its needed effects, alitretinoin topical (the active ingredient contained in Panretin) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor as soon as possible if any of the following side effects occur while taking alitretinoin topical:

Other side effects of Panretin

Some side effects of alitretinoin topical may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

For healthcare professionals

Applies to alitretinoin topical: topical gel.

General adverse events

The most frequently reported side effects occurred almost exclusively at the application site. Dermal toxicity began as erythema, which could worsen and result in edema with continued use. This toxicity may be treatment-limiting, with intense erythema, edema, and vesiculation. Side effects were typically mild to moderate in severity and led to study withdrawal in 7% of patients. During one study, severe local (application site) skin reactions were reported in about 10% of patients.^[Ref]

Local

• Very common (10% or more): Rash (up to 77%), pain (34%), paresthesia (up to 22%), pruritus (up to 11%)
• Common (1% to 10%): Exfoliative dermatitis, skin disorder, edema^[Ref]

Side effects occurred almost exclusively at the application site and have included application site rash (term includes erythema, scaling, irritation, redness, dermatitis), pain (term includes burning, pain), pruritus (term includes itching, pruritus), exfoliative dermatitis (term includes flaking, peeling, desquamation, exfoliation), skin disorder (term includes excoriation, cracking, scab, crusting, drainage, eschar, fissure, or oozing), paresthesia (term includes stinging, tingling), and edema (term includes edema, swelling, inflammation).^[Ref]

See also:

Further information

Panretin side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following this guide.

Medical Disclaimer