Panretin Side Effects
Generic Name: alitretinoin topical
Note: This page contains side effects data for the generic drug alitretinoin topical. It is possible that some of the dosage forms included below may not apply to the brand name Panretin.
Common side effects of Panretin include: pain, pruritus, and skin rash. Other side effects include: exfoliative dermatitis, dermatological disease, and skin edema. See below for a comprehensive list of adverse effects.
For the Consumer
Applies to alitretinoin topical: topical gel/jelly
As well as its needed effects, alitretinoin topical (the active ingredient contained in Panretin) may cause unwanted side effects that require medical attention.
If any of the following side effects occur while taking alitretinoin topical, check with your doctor or nurse as soon as possible:More common:
- Abrasion of skin
- blisters on skin
- burning pain
- cracking, crusting, drainage, or oozing of the skin
- groove in the skin
- peeling of skin
- severe rash
- skin redness
- sloughing of skin
- swelling at the site of application
- Stinging or tingling of skin
Minor Side Effects
Some alitretinoin topical side effects may not need any medical attention. As your body gets used to the medicine these side effects may disappear. Your health care professional may be able to help you prevent or reduce these side effects, but do check with them if any of the following side effects continue, or if you are concerned about them:More common:
- Increased sensitivity to the sun
For Healthcare Professionals
Applies to alitretinoin topical: topical gel
The most frequently reported side effects occurred almost exclusively at the application site. Dermal toxicity began as erythema, which could worsen and result in edema with continued use. This toxicity may be treatment-limiting, with intense erythema, edema, and vesiculation. Side effects were typically mild to moderate in severity and led to study withdrawal in 7% of patients. During one study, severe local (application site) skin reactions were reported in about 10% of patients.[Ref]
Very common (10% or more): Rash (up to 77%), pain (34%), paresthesia (up to 22%), pruritus (up to 11%)
Common (1% to 10%): Exfoliative dermatitis, skin disorder, edema[Ref]
Side effects occurred almost exclusively at the application site and have included application site rash (term includes erythema, scaling, irritation, redness, dermatitis), pain (term includes burning, pain), pruritus (term includes itching, pruritus), exfoliative dermatitis (term includes flaking, peeling, desquamation, exfoliation), skin disorder (term includes excoriation, cracking, scab, crusting, drainage, eschar, fissure, or oozing), paresthesia (term includes stinging, tingling), and edema (term includes edema, swelling, inflammation).[Ref]
1. "Product Information. Panretin (alitretinoin topical)." Ligand Pharmaceuticals, San Diego, CA.
It is possible that some side effects of Panretin may not have been reported. These can be reported to the FDA here. Always consult a healthcare professional for medical advice.
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