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Oxervate Side Effects

Generic name: cenegermin ophthalmic

Medically reviewed by Last updated on Mar 10, 2022.

Note: This document contains side effect information about cenegermin ophthalmic. Some of the dosage forms listed on this page may not apply to the brand name Oxervate.

For the Consumer

Applies to cenegermin ophthalmic: ophthalmic solution

Side effects requiring immediate medical attention

Along with its needed effects, cenegermin ophthalmic (the active ingredient contained in Oxervate) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Side effects not requiring immediate medical attention

Some side effects of cenegermin ophthalmic may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  • Decreased vision or any change in vision
  • feeling of having something in the eye
  • irritation, pain, redness, or swelling of the eye
  • tearing

For Healthcare Professionals

Applies to cenegermin ophthalmic: ophthalmic kit


The most commonly reported adverse reactions have included eye pain, ocular hyperemia, eye inflammation, and increased lacrimation.[Ref]


Very common (10% or more): Eye pain (16%)

Common (1% to 10%): Corneal deposits, foreign body sensation, ocular hyperemia, ocular inflammation, tearing, photophobia, conjunctival hyperemia, eye irritation, eyelid pain, blepharitis, increased lacrimation

Uncommon (0.1% to 1%): Corneal abscess, corneal neovascularization[Ref]

Nervous system

Common (1% to 10%): Headache[Ref]

Frequently asked questions

More about Oxervate (cenegermin ophthalmic)

Patient resources

Professional resources

Related treatment guides


1. "Product Information. Oxervate (cenegermin ophthalmic)." Dompe U.S. Inc., San Bruno, CA.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.