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Oxervate Dosage

Medically reviewed by Drugs.com. Last updated on Oct 28, 2020.

Generic name: CENEGERMIN 20ug in 1mL
Dosage form: ophthalmic solution

General Dosing Information

Contact lenses should be removed before applying OXERVATE and may be reinserted 15 minutes after administration.

If a dose is missed, treatment should be continued as normal, at the next scheduled administration.

If more than one topical ophthalmic product is being used, administer the eye drops at least 15 minutes apart to avoid diluting products. Administer OXERVATE 15 minutes prior to using any eye ointment, gel or other viscous eye drops.

Recommended Dosage and Dose Administration

Instill one drop of OXERVATE in the affected eye(s), 6 times a day at 2-hour intervals for eight weeks.

Preparation for Administration

Remove the weekly cartons of OXERVATE from the insulated container and store it for up to 14 days in a refrigerator (no later than 5 hours from when you receive the medicine from your pharmacy). OXERVATE is stored in a freezer at the pharmacy. If treatment is started immediately after receiving the weekly carton, wait until the first vial is thawed (this could take up to 30 minutes when kept at room temperature up to 77°F (25°C)). Do not shake the vial.

Follow Steps 1 to 19 each day you use OXERVATE:

Take an individual vial of OXERVATE from the refrigerator in the morning and prepare it in the following way:

Step 1. Wash your hands.


Step 2. If you wear contact lenses, take them out before using OXERVATE.

Step 3. Remove the plastic flip-off cap from the vial.

IFU Step 3

Step 4. Peel-off the back of the vial adapter blister pack.

IFU Step 4

Step 5. Without removing the vial adapter from its blister pack, connect it to the vial by firmly pushing it down until it snaps into place over the neck of the vial. The spike of the vial adapter should pierce through the vial’s rubber stopper. After the vial adapter has been connected correctly, do not remove it from the vial.

Note: After the vial adapter is connected to the vial, OXERVATE can be stored in the refrigerator between 36°F to 46°F (2°C to 8°C) for up to 12 hours.

If needed, the OXERVATE with the connected vial adapter may be stored at room temperature up to 77°F (25°C).

Step 6. Remove and throw away the packaging of the vial adapter.

IFU Steps 5 and 6

The multi-dose vial of OXERVATE is now ready for use (1 drop in the affected eye every 2 hours six times a day).

To withdraw and give each dose of OXERVATE, follow the Steps 7 to 19:

Step 7. Take a single sterile disinfectant wipe and gently clean the surface of the valve on the connector part of the vial adapter.

After cleaning, wait for about 1 minute to allow the valve to dry.

IFU Step 7

Step 8. Remove a pipette from its protective packaging.

IFU Step 8

Step 9. Screw the pipette (clockwise) into the connector part of the vial adapter.


Step 10. Make sure that the pipette plunger is pushed all the way down.

IFU Steps 9 and 10

Step 11. Turn the vial upside-down with the pipette still connected. Gently pull the plunger until it stops, to draw the eye drop solution into the pipette. Make sure the plunger has reached the stop point.


Step 12. Check the pipette to make sure it contains the eye drop solution. Air bubbles may cause blockage and prevent the pipette from filling properly (especially the first time you withdraw the eye drop solution). If the pipette is empty, keep the vial with the connected pipette upside-down, push the plunger all the way in and pull it out again.

IFU Steps 11 and 12

Step 13. After the pipette has been correctly filled, unscrew the pipette from the connector part of the vial adapter (counter-clockwise). Pull the pipette straight up to remove it.

IFU Step 13

Step 14.

  • Sit or lie down to steady yourself when you instill OXERVATE.
  • Holding the pipette, pointing down, between your middle finger and thumb, tilt your head back and position the pipette above your affected eye.
  • With your other hand, pull down your lower eyelid, increasing the space between the inner eyelid and the eyeball (the conjunctival fornix).
  • Gently push the plunger down until at least a drop is released into the conjunctival fornix.
  • Make sure you do not touch your eye with the tip of the pipette.
  • With your head still tilted back, blink a few times so that the medicine covers the surface of your eye.
IFU Step 14

Step 15. Throw away the used pipette right away after use, even if there is still some eye drop solution left in it.


If you miss your eye and there is no longer eye drop solution in the pipette, try again, using a new pipette and wipe (See Steps 7 to 14).

Step 16. After each use throughout the day, place the vial back in the refrigerator or keep it below 77°F (25°C) for the rest of the day, with the vial adapter still connected.

IFU Step 16

Step 17. Repeat from Step 7 to Step 16 every 2 hours 6 times a day, using a new sterile disinfectant wipe and a new pipette each time.


If you use drops in both eyes, repeat the above instructions for your other eye using a new pipette. You will need to use 2 vials each day.


Store the vial below 77°F (25°C) throughout the day. You can also store the vial in the refrigerator but do not freeze the vial.

Step 18. Throw away the used vial at the end of each day even if there is still some eye drop solution left in it. Throw away the vial no later than 12 hours from the time you connected the vial adapter to it.

IFU Step 18

Step 19. Track each time you instill an eye drop of OXERVATE on the weekly Dose Recording Card provided with the delivery system.


This will allow you to track your 6 doses each treatment day, the date of the first use of the weekly supply and the time of the vial opening (which is when you connect the vial adapter to the vial) during the week.

IFU Step 19

To make sure accurate dosing every 2 hours, you may want to set an alarm as a reminder for dosing.

Frequently asked questions

More about Oxervate (cenegermin ophthalmic)

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Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.