Oxbryta Side Effects

Generic name: voxelotor

Medically reviewed by Drugs.com. Last updated on Jan 5, 2025.

Note: This document provides detailed information about Oxbryta Side Effects associated with voxelotor. Some dosage forms listed on this page may not apply specifically to the brand name Oxbryta.

Applies to voxelotor: oral tablet, oral tablet for suspension.

Precautions

It is very important that your doctor check your or your child's progress at regular visits to make sure that this medicine is working properly. Blood tests may be needed to check for unwanted effects.

You should not take this medicine together with St John's wort.

This medicine may cause serious allergic reactions, which can be life-threatening and requires immediate medical attention. Tell your doctor right away if you have a rash or itching skin, chest pain, fever or chills, mild swelling of the face, trouble breathing, or unusual tiredness or weakness while using this medicine.

This medicine may cause serious skin reactions, including drug reaction with eosinophilia and systemic symptoms (DRESS), which can be life-threatening and requires immediate medical attention. Check with your doctor right away if you have black, tarry stools, chest pain, chills, cough, painful or difficult urination, sore throat, sores, ulcers, or white spots on the lips or in the mouth, swollen glands, trouble breathing, unusual bleeding or bruising, or unusual tiredness or weakness.

Do not change your dose or Stop taking voxelotor (the active ingredient contained in Oxbryta) without checking first with your doctor.

Before you have any medical tests, tell the medical doctor in charge that you are taking this medicine. The results of some tests may be affected by this medicine.

Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements.

Common side effects of Oxbryta

Some side effects of voxelotor may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Serious side effects of Oxbryta

Along with its needed effects, voxelotor may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking voxelotor:

For healthcare professionals

Applies to voxelotor: oral tablet, oral tablet soluble.

General adverse events

The more commonly reported adverse reactions have included headache, diarrhea, abdominal pain, nausea, fatigue, rash, and pyrexia^[Ref]

Hypersensitivity

• Rare (less than 0.1%): Serious hypersensitivity reactions
• Frequency not reported: Drug hypersensitivity

Clinical manifestations of serious hypersensitivity reactions may include generalized rash, urticaria, mild shortness of breath, mild facial swelling, and eosinophilia. Drug hypersensitivity has been reported in less than 10% of patients.

Gastrointestinal

• Very common (10% or more): Diarrhea (up to 23%), abdominal pain (up to 23%; including abdominal pain, lower abdominal pain, and upper abdominal pain), nausea (up to 19%), vomiting (33%)

Dermatologic

• Very common (10% or more): Rash (up to 20%)

Rash includes terms of rash, urticaria, generalized rash, maculo-papular rash, pruritic rash, papular rash, erythematous rash, and vesicular rash.

Other

• Very common (10% or more): Fatigue (14%), pyrexia (up to 36%)

Nervous system

• Very common (10% or more): Headache (up to 32%)

See also:

Further information

Oxbryta side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following this guide.

Medical Disclaimer