NexoBrid Side Effects
Generic name: anacaulase topical
Medically reviewed by Drugs.com. Last updated on Mar 20, 2025.
Note: This document provides detailed information about NexoBrid.
Applies to anacaulase topical: topical application gel/jelly Side Effects associated with anacaulase topical. Some dosage forms listed on this page may not apply specifically to the brand name NexoBrid.
Applies to anacaulase topical: topical application gel/jelly.
Precautions
It is very important that your doctor check your progress closely to make sure this medicine is working properly and to check for unwanted effects.
This medicine may cause serious allergic reaction, including anaphylaxis, which can be life-threatening and requires immediate medical attention. Check with your doctor right away if you have chest tightness, cough, difficulty swallowing, dizziness, fast heartbeat, hives, itching, or skin rash, puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue, trouble breathing, or unusual tiredness or weakness.
Serious side effects of NexoBrid
Along with its needed effects, anacaulase topical (the active ingredient contained in NexoBrid) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor or nurse immediately if any of the following side effects occur while taking anacaulase topical:
More common side effects
- pale skin
- trouble breathing
- unusual bleeding or bruising
- unusual tiredness or weakness
Less common side effects
- bladder pain
- bloody or cloudy urine
- blurred vision
- confusion
- cough or hoarseness
- difficult, burning, or painful urination
- dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
- eye pain
- fast, pounding, or irregular heartbeat or pulse
- fever or chills
- frequent urge to urinate
- general feeling of illness
- headache
- lower back or side pain
- sore throat
- stomach pain
- sweating
Incidence not known
- chest tightness
- difficulty swallowing
- hives, itching, skin rash
- puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
Other side effects of NexoBrid
Some side effects of anacaulase topical may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.
Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
More common side effects
- trouble sleeping
- vomiting
Less common side effects
- scar
For healthcare professionals
Applies to anacaulase topical: topical gel.
General adverse events
The most common adverse reactions with a frequency of greater than 10% were pruritus and pyrexia.
Dermatologic
Gastrointestinal
- Common (1% to 10%): Vomiting[Ref]
Cardiovascular
- Common (1% to 10%): Tachycardia[Ref]
Genitourinary
- Common (1% to 10%): Urinary tract infection[Ref]
Hematologic
- Common (1% to 10%): Anemia, hypotension, leukocytosis, subcutaneous hematoma[Ref]
Hepatic
- Common (1% to 10%): Abnormal hepatic function[Ref]
Hypersensitivity
- Common (1% to 10%): Drug hypersensitivity
- Postmarketing reports: Hypersensitivity (including anaphylaxis and urticaria)[Ref]
Local
- Common (1% to 10%): Wound complication[Ref]
Wound complication includes skin graft failure, graft loss, graft complication, and wound decomposition.[Ref]
Nervous system
Other
- Common (1% to 10%): Bacteremia, infection, sepsis[Ref]
See also:
Botox
Botox is used for cosmetic purposes and to treat overactive bladder symptoms, urinary incontinence ...
Collagenase topical
Collagenase topical is used for dermal ulcer, keratosis
Balsam peru/castor oil/trypsin topical
Balsam peru/castor oil/trypsin topical is used for dermatologic lesion
References
1. (2022) "Product Information. Nexobrid (anacaulase topical)." Vericel Corporation
More about NexoBrid (anacaulase topical)
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Further information
NexoBrid side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following this guide.