NexoBrid Side Effects

Generic name: anacaulase topical

Medically reviewed by Drugs.com. Last updated on Mar 20, 2025.

Note: This document provides detailed information about NexoBrid.

Applies to anacaulase topical: topical application gel/jelly Side Effects associated with anacaulase topical. Some dosage forms listed on this page may not apply specifically to the brand name NexoBrid.

Applies to anacaulase topical: topical application gel/jelly.

Precautions

It is very important that your doctor check your progress closely to make sure this medicine is working properly and to check for unwanted effects.

This medicine may cause serious allergic reaction, including anaphylaxis, which can be life-threatening and requires immediate medical attention. Check with your doctor right away if you have chest tightness, cough, difficulty swallowing, dizziness, fast heartbeat, hives, itching, or skin rash, puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue, trouble breathing, or unusual tiredness or weakness.

Serious side effects of NexoBrid

Along with its needed effects, anacaulase topical (the active ingredient contained in NexoBrid) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur while taking anacaulase topical:

Other side effects of NexoBrid

Some side effects of anacaulase topical may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

For healthcare professionals

Applies to anacaulase topical: topical gel.

General adverse events

The most common adverse reactions with a frequency of greater than 10% were pruritus and pyrexia.

Dermatologic

• Very common (10% or more): Pruritus (15%)
• Common (1% to 10%): Decubitus ulcer, rash, scar^[Ref]

Gastrointestinal

• Common (1% to 10%): Vomiting^[Ref]

Cardiovascular

• Common (1% to 10%): Tachycardia^[Ref]

Genitourinary

• Common (1% to 10%): Urinary tract infection^[Ref]

Hematologic

• Common (1% to 10%): Anemia, hypotension, leukocytosis, subcutaneous hematoma^[Ref]

Hepatic

• Common (1% to 10%): Abnormal hepatic function^[Ref]

Hypersensitivity

• Common (1% to 10%): Drug hypersensitivity
• Postmarketing reports: Hypersensitivity (including anaphylaxis and urticaria)^[Ref]

Local

• Common (1% to 10%): Wound complication^[Ref]

Wound complication includes skin graft failure, graft loss, graft complication, and wound decomposition.^[Ref]

Nervous system

• Very common (10% or more): Pyrexia (12%)
• Common (1% to 10%): Insomnia^[Ref]

Other

• Common (1% to 10%): Bacteremia, infection, sepsis^[Ref]

See also:

Further information

NexoBrid side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following this guide.

Medical Disclaimer