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Natrol SAMe Side Effects

Generic name: s-adenosylmethionine

Note: This document contains side effect information about s-adenosylmethionine. Some of the dosage forms listed on this page may not apply to the brand name Natrol SAMe.

Applies to s-adenosylmethionine: oral tablet

Warning

You should not use SAMe if you are also using a prescription antidepressant medicine.

Do not use SAMe if you have used an MAO inhibitor in the past 14 days. A dangerous drug interaction could occur. MAO inhibitors include isocarboxazid, linezolid, methylene blue injection, phenelzine, rasagiline, selegiline, tranylcypromine, and others.

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Although not all side effects are known, SAMe is thought to be likely safe for most adults.

Common side effects may include:

  • headache, dizziness;

  • feeling anxious or nervous;

  • vomiting, upset stomach;

  • diarrhea, constipation;

  • increased sweating; or

  • sleep problems (insomnia).

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.

More about Natrol SAMe (s-adenosylmethionine)

Professional resources

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Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.