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Migalastat Side Effects

Medically reviewed by Last updated on Feb 11, 2022.

For the Consumer

Applies to migalastat: oral capsule

Side effects requiring immediate medical attention

Along with its needed effects, migalastat may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking migalastat:

More common

  • Bladder pain
  • bloody or cloudy urine
  • difficult, burning, or painful urination
  • frequent urge to urinate
  • lower back or side pain

Side effects not requiring immediate medical attention

Some side effects of migalastat may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

For Healthcare Professionals

Applies to migalastat: oral capsule


The more commonly reported adverse effects have included headache, nasopharyngitis, urinary tract infection, nausea, and pyrexia.[Ref]

Nervous system

Very common (10% or more): Headache (35%)

Common (1% to 10%): Paresthesia, dizziness, hypoesthesia


Very common (10% or more): Nasopharyngitis (18%)

Common (1% to 10%): Cough, epistaxis, dyspnea


Common (1% to 10%): Proteinuria


Very common (10% or more): Nausea (12%)

Common (1% to 10%): Abdominal pain, diarrhea, vomiting, constipation, dry mouth, defection urgency, dyspepsia


Common (1% to 10%): Back pain, muscle spasms, myalgia, torticollis, extremity pain, increased blood creatine phosphokinase


Common (1% to 10%): Increased weight


Very common (10% or more): Urinary tract infection (15%)

Urinary tract infection includes cystitis, and kidney infection.


Common (1% to 10%): Pyrexia, vertigo, fatigue


Common (1% to 10%): Depression


Common (1% to 10%): Palpitations


Common (1% to 10%): Rash, pruritus

Frequently asked questions


1. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0

2. "Product Information. Galafold (migalastat)." Amicus Therapeutics U.S., Inc. (2018):

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.