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MicRhoGAM Ultra-Filtered Plus Side Effects

Generic Name: rho (d) immune globulin

Note: This document contains side effect information about rho (d) immune globulin. Some of the dosage forms listed on this page may not apply to the brand name MicRhoGAM Ultra-Filtered Plus.

For the Consumer

Applies to rho (d) immune globulin: injectable, powder for solution, solution

Along with its needed effects, rho (d) immune globulin (the active ingredient contained in MicRhoGAM Ultra-Filtered Plus) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur while taking rho (d) immune globulin:

  • Bloody urine
  • decreased frequency of urination or amount of urine
  • fever
  • increased blood pressure
  • increased thirst
  • loss of appetite
  • lower back pain
  • nausea or vomiting
  • pale skin
  • swelling of the face, fingers, or lower legs
  • troubled breathing
  • unusual bleeding or bruising
  • unusual tiredness or weakness
  • weight gain

Some side effects of rho (d) immune globulin may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common
  • Soreness at the place of injection

For Healthcare Professionals

Applies to rho (d) immune globulin: injectable powder for injection, injectable solution, intramuscular powder for injection, intramuscular solution


Very common (10% or more): Chills (34.7%), pyrexia/increased body temperature (32.6%)
Uncommon (0.1% to 1%): Malaise
Very rare (less than 0.01%): Death
Frequency not reported: Shivering, weakness
Postmarketing reports: Chest pain, fatigue, edema[Ref]


Hemolytic reaction includes hypotension, nausea, chills, headache, and a decrease in haptoglobin and hemoglobin.[Ref]

Very rare (less than 0.01%): Disseminated intravascular coagulation
Frequency not reported: Intravascular hemolysis, hemolysis resulting in death, clinically compromising anemia, extravascular hemolysis, hemolytic reaction
Postmarketing reports: Hemoglobinemia, disseminated intravascular coagulation[Ref]


Uncommon (0.1% to 1%): Injection site swelling, injection site pain
Rare (less than 0.1%): Injection site erythema, injection site induration, injection site warmth, injection site pruritus, injection site rash[Ref]

Nervous system

Very common (10% or more): Headache (14.3%)
Uncommon (0.1% to 1%): Dizziness, vertigo[Ref]


Uncommon (0.1% to 1%): Nausea, vomiting
Rare (less than 0.1%): Diarrhea[Ref]


Rare (less than 0.1%): Tachycardia, hypotension
Frequency not reported: Increase in blood pressure
Postmarketing reports: Cardiac arrest, cardiac failure, myocardial infarction[Ref]


Uncommon (0.1% to 1%): Skin reaction, erythema, pruritus, pallor, rash
Postmarketing reports: Hyperhidrosis[Ref]


Rare (less than 0.1%): Arthralgia, back pain
Postmarketing reports: Myalgia, muscle spasm, pain in extremities[Ref]


Very common (10% or more): Increase in blood bilirubin (21.4%)
Postmarketing reports: Jaundice[Ref]


Rare (less than 0.1%): Hypersensitivity, anaphylactic shock, anaphylactic reaction[Ref]


The most common adverse events were chills, pyrexia, increased bilirubin, and headache.[Ref]


Rare (less than 0.1%): Dyspnea
Postmarketing reports: Acute respiratory distress syndrome, transfusion related acute lung injury[Ref]


Frequency not reported: Acute renal insufficiency
Postmarketing reports: Renal failure, renal impairment[Ref]


Uncommon (0.1% to 1%): Transient positive anti-C antibody test
Frequency not reported: Sensitization to repeated injections of human globulin[Ref]


Postmarketing reports: Hemoglobinuria, anuria, chromaturia, hematuria[Ref]


1. "Product Information. RhoGAM Ultra-Filtered Plus (RHo (D) immune globulin)." Kedrion Biopharma Inc, Cambridge, MA.

2. Cerner Multum, Inc. "Australian Product Information." O 0

3. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0

4. "Product Information. Rhophylac (RHo (D) immune globulin)." ZLB Bioplasma Inc, Glendale, CA.

5. "Product Information. WinRho SDF (RHo (D) immune globulin)." Nabi, Boca Raton, FL.

6. "Product Information. HyperRHO S/D Full Dose (RHo (D) immune globulin)." Talecris Biotherapeutics, Research Triangle Park, NC.

7. "Product Information. BayRHo-D (RHo (D) immune globulin)." Bayer, West Haven, CT.

Some side effects of MicRhoGAM Ultra-Filtered Plus may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.