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Meruvax II Side Effects

Generic name: rubella virus vaccine

Note: This document contains side effect information about rubella virus vaccine. Some of the dosage forms listed on this page may not apply to the brand name Meruvax II.

Applies to rubella virus vaccine: subcutaneous powder for injection

Local

Local side effects have included injection site burning/stinging, wheal and flare, erythema, pain, and induration.[Ref]

Hypersensitivity

Hypersensitivity reactions have included anaphylaxis, anaphylactoid reactions, angioneurotic edema (including peripheral or facial edema), and bronchial spasm.[Ref]

Cardiovascular

Cardiovascular side effects have included vasculitis.[Ref]

Dermatologic

Dermatologic side effects have included Stevens-Johnson Syndrome, erythema multiforme, urticaria, and rash.[Ref]

Gastrointestinal

Gastrointestinal side effects have included pancreatitis; diarrhea, vomiting, and nausea.[Ref]

Hematologic

Hematologic side effects have included thrombocytopenia, purpura, regional lymphadenopathy, and leukocytosis.[Ref]

Musculoskeletal

The vaccine has rarely been associated with chronic joint symptoms. The incidence of arthritis and arthralgia is generally higher in adult women than in children (women, 12% to 26%; children, 0% to 3%), and symptoms tend to be more marked and of longer duration, persisting for months or years (rare). In adolescent girls, the incidence of reactions appears to be intermediate between those seen in children and in women. These reactions are generally well tolerated and rarely interfere with normal activities, even in women over 35 years old.[Ref]

Musculoskeletal side effects have included arthralgia and/or arthritis (usually transient and rarely chronic), myalgia, paresthesia, and rarely chronic arthritis; these symptoms may also occur with natural rubella.[Ref]

Nervous system

Nervous system side effects have included encephalitis, Guillain-Barré Syndrome (GBS), polyneuritis, polyneuropathy, and paresthesia.[Ref]

Ocular

Ocular side effects have included optic neuritis, papillitis, retrobulbar neuritis, and conjunctivitis.[Ref]

Other

Otic side effects have included nerve deafness and otitis media.[Ref]

Respiratory

Respiratory side effects have included sore throat, cough, and rhinitis.[Ref]

Other

A postmarketing surveillance study of measles/mumps/rubella vaccine in Finland during 1982 to 1993 with 1.5 million pediatric and adult vaccinees reported no deaths or permanent sequelae.[Ref]

Other side effects have included fever, syncope, headache, dizziness, malaise, and irritability. Fatalities have been reported with the polyvalent measles/mumps/rubella vaccine; however, causality has not been determined.

Health care providers should report any allergic or unusual adverse reactions to the Vaccine Adverse Event Reporting System (VAERS) at 1-800-822-7967 (USA) and the manufacturer.[Ref]

References

1. "Product Information. Meruvax II (rubella virus vaccine, live)." Merck & Co, Inc, West Point, PA.

Medically reviewed by Drugs.com. Last updated on June 23, 2020.

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Some side effects may not be reported. You may report them to the FDA.