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Menotropins Side Effects

Medically reviewed by Last updated on Oct 10, 2022.


Commonly reported side effects of menotropins include: ovarian hyperstimulation syndrome, abdominal pain, headache, injection site reaction, and nausea. Other side effects include: respiratory system disorder, abdominal cramps, increased cough, vomiting, epigastric fullness, pain at injection site, and postoperative pain. Continue reading for a comprehensive list of adverse effects.

Applies to menotropins: powder for solution.

Serious side effects of Menotropins

Along with its needed effects, menotropins may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking menotropins:

For females only

Less common

  • Back pain
  • breast tenderness
  • feeling of warmth, redness of the face, neck, arms, and occasionally, upper chest
  • menstrual changes
  • muscle aches and pains
  • unusual tiredness or weakness

Less common or rare

  • Abdominal or stomach pain (severe)
  • bloating (moderate to severe)
  • chest pain or trouble breathing
  • decreased amount of urine
  • feeling of indigestion
  • general feeling of discomfort or illness
  • headache, severe and throbbing
  • nausea, vomiting, or diarrhea (continuing or severe)
  • pain or swelling in the arms or legs
  • pelvic pain (severe)
  • severe cramping of the uterus
  • shortness of breath or wheezing
  • swelling of the lower legs
  • weight gain (rapid)

Other side effects of Menotropins

Some side effects of menotropins may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

For females only

Less common

  • Enlargement of the breasts
  • headache
  • pain, swelling, or irritation at the injection site
  • rash at the injection site
  • stomach cramps, fullness, or pain

After you stop using this medicine, it may still produce some side effects that need attention. During this period of time, Check with your doctor immediately if you notice the following side effects:

For females only

  • Abdominal or stomach pain (severe)
  • bloating (moderate to severe)
  • decreased amount of urine
  • feeling of indigestion
  • nausea, vomiting, or diarrhea (continuing or severe)
  • pelvic pain (severe)
  • shortness of breath
  • weight gain (rapid)

For Healthcare Professionals

Applies to menotropins: injectable powder for injection, intramuscular powder for injection, subcutaneous powder for injection.


The most frequently reported adverse drug reactions reported are abdominal pain, headache, injection site reactions, and injection site pain[Ref]


Very common (10% or more): Multiple pregnancy (35.3%)

Common (1% to 10%): Ovarian Hyperstimulation Syndrome (OHSS), abnormal ovarian enlargement, ovarian disease, vaginal hemorrhage, pelvic pain, breast pain, ectopic pregnancy

Postmarketing reports: Ovarian cyst, breast complaints (including breast tenderness, breast discomfort and breast swelling)

Frequency not reported: Ovarian torsion[Ref]


Common (1% to 10%): Abdominal pain, abdominal cramps, enlarged abdomen, nausea and vomiting, diarrhea, fullness and pain

Postmarketing reports: Nausea, abdominal pain lower, abdominal distension, abdominal discomfort

Frequency not reported: Diarrhea[Ref]


Common (1% to 10%): Infection

Frequency not reported: Formation of antibodies[Ref]


Common (1% to 10%): Injection site pain/reaction, injection site inflammation, injection site edema[Ref]

Nervous system

Common (1% to 10%): Headache

Postmarketing reports: Dizziness[Ref]


Common (1% to 10%): Dyspnea[Ref]


Uncommon (0.1% to 1%): Thrombophlebitis, deep vein thrombosis

Postmarketing reports: Hot flush[Ref]


Frequency not reported: Hypersensitivity[Ref]


Postmarketing reports: Acne, rash, pruritus[Ref]


Postmarketing reports: Arthralgia[Ref]


Postmarketing reports: Visual disorders (blurred vision, vision impairment including amaurosis, diplopia, mydriasis, photopsia, scotoma and vitreous floaters)[Ref]


Postmarketing reports: Fatigue, pyrexia[Ref]


1. "Product Information. Menopur (menotropins)." Ferring Pharmaceuticals Inc (2006):

2. "Product Information. Repronex (menotropins)." Ferring Pharmaceuticals Inc (2006):

3. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0

4. Cerner Multum, Inc. "Australian Product Information." O 0

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.