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Lupkynis Side Effects

Generic name: voclosporin

Medically reviewed by Philip Thornton, DipPharm. Last updated on Oct 22, 2022.

Note: This document contains side effect information about voclosporin. Some dosage forms listed on this page may not apply to the brand name Lupkynis.

Applies to voclosporin: oral capsule liquid filled.

Warning

Oral route (Capsule)

Warning: Malignancies and Serious InfectionsIncreased risk for developing malignancies and serious infections with voclosporin or other immunosuppressants that may lead to hospitalization or death.

Serious side effects of Lupkynis

Along with its needed effects, voclosporin (the active ingredient contained in Lupkynis) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking voclosporin:

More common

  • Agitation
  • anxiety
  • back pain
  • black, tarry stools
  • bloody or cloudy urine
  • blurred vision
  • body aches or pain
  • burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
  • change in frequency of urination or amount of urine
  • chest pain or discomfort
  • chills
  • coma
  • confusion
  • cough
  • decreased urine output
  • diarrhea
  • difficult, burning, or painful urination
  • dizziness
  • drowsiness
  • dry mouth
  • ear congestion
  • fainting
  • fever
  • frequent urge to urinate
  • general feeling of illness
  • hallucinations
  • headache
  • hostility
  • increased thirst
  • irregular or slow heart rate
  • irritability
  • loss of appetite
  • loss of voice
  • lower back or side pain
  • mood or mental changes
  • muscle twitching
  • nausea or vomiting
  • nervousness
  • numbness or tingling in the hands, feet, or lips
  • painful blisters on trunk of body
  • pale skin
  • pounding in the ears
  • rapid weight gain
  • restlessness
  • seizures
  • slow or fast heartbeat
  • sneezing
  • sore throat
  • stiff neck
  • stomach pain
  • stuffy or runny nose
  • swelling of the face, feet, lower legs, ankles, or hands
  • swollen glands
  • trouble breathing
  • unusual bleeding or bruising
  • unusual tiredness or weakness
  • weakness or heaviness of the legs
  • weight loss
  • yellow skin and eyes

Less common

  • Persistent non-healing sore
  • pink growth
  • reddish patch or irritated area
  • shakiness in the legs, arms, hands, feet
  • shiny bump
  • trembling or shaking of the hands or feet
  • white, yellow or waxy scar-like area

Other side effects of Lupkynis

Some side effects of voclosporin may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

Less common

  • Decreased appetite
  • irritation or soreness of the mouth

For Healthcare Professionals

Applies to voclosporin: oral capsule.

Hematologic

Very common (10% or more): Anemia (12%)[Ref]

Ocular

Frequency not reported: Cytomegalovirus chorioretinitis[Ref]

Metabolic

Frequency not reported: Hyperkalemia[Ref]

Genitourinary

Very common (10% or more): Urinary tract infection (10%)

Frequency not reported: Azotemia, oliguria, proteinuria[Ref]

Oncologic

Frequency not reported: Cervical carcinoma, breast tumor excision, malignant lymphoma, malignant neoplasm, skin neoplasm[Ref]

Respiratory

Very common (10% or more): Cough (11%)

Frequency not reported: Pneumonia, bacterial and viral upper respiratory tract infection[Ref]

Nervous system

Very common (10% or more): Headache (15%)

Common (1% to 10%): Fatigue, tremor

Frequency not reported: Nervous system disorders, headache, tremor, dizziness, post herpetic neuralgia, migraine, paresthesia, hypoesthesia, seizure, tension headache, and disturbance in attention, migraine, seizure, and posterior reversible encephalopathy syndrome[Ref]

Renal

Very common (10% or more): Decrease in glomerular filtration rate (26%)

Common (1% to 10%): Acute kidney injury, renal dysfunction

Frequency not reported: Renal impairment, acute kidney injury, increased blood creatinine, renal failure

Cardiovascular

Very common (10% or more): Hypertension (19%)

Frequency not reported: QT prolongation[Ref]

Dermatologic

Common (1% to 10%): Alopecia, hypertrichosis

Frequency not reported: Pyoderma gangrenosum[Ref]

Gastrointestinal

Very common (10% or more): Diarrhea (19%)

Common (1% to 10%): Abdominal pain, decreased appetite, dyspepsia, gingivitis, mouth ulceration, upper abdominal pain

Frequency not reported: Gastroenteritis[Ref]

Other

Frequency not reported: Herpes zoster infection, serious infections, opportunistic infection (including cytomegalovirus infection, and herpes zoster cutaneous disseminated)

General

The most frequently reported side effect was decreased in glomerular filtration rate.[Ref]

Frequently asked questions

References

1. "Product Information. Lupkynis (voclosporin)." Aurinia Pharma (2021):

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.