Lumoxiti Side Effects

Generic name: moxetumomab pasudotox

Medically reviewed by Drugs.com. Last updated on Dec 26, 2024.

Note: This document provides detailed information about Lumoxiti Side Effects associated with moxetumomab pasudotox. Some dosage forms listed on this page may not apply specifically to the brand name Lumoxiti.

Applies to moxetumomab pasudotox: intravenous powder for solution.

Precautions

It is very important that your doctor check your progress while you are receiving this medicine to make sure this medicine is working properly. Blood and urine tests may be needed to check for unwanted effects.

Receiving this medicine while you are pregnant can harm your unborn baby. Use an effective form of birth control to keep from getting pregnant during treatment with this medicine and for at least 30 days after the last dose. If you think you have become pregnant while receiving this medicine, tell your doctor right away.

This medicine may cause a condition called capillary leak syndrome. It can cause fluid to leak from the blood vessels into your body's tissues. Call your doctor right away if you have swelling or puffiness and are urinating less often, trouble breathing, feeling of fullness, dizziness, or feeling faint.

This medicine may cause kidney problems, including hemolytic uremic syndrome and kidney failure. Check with your doctor right away if you have stomach pain, blood in the urine, fever, increased or decreased urination, pinpoint red spots on the skin, swelling of the face, fingers, feet, or lower legs, unusual bleeding or bruising, unusual tiredness or weakness, or yellow eyes or skin.

This medicine may cause infusion-related reactions, which can be life-threatening and require immediate medical attention. Tell your doctor right away if you start to have a fever, chills or shaking, dizziness, trouble breathing, itching or rash, lightheadedness or fainting after receiving this medicine.

Serious side effects of Lumoxiti

Along with its needed effects, moxetumomab pasudotox (the active ingredient contained in Lumoxiti) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur while taking moxetumomab pasudotox:

Other side effects of Lumoxiti

Some side effects of moxetumomab pasudotox may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

For healthcare professionals

Applies to moxetumomab pasudotox: intravenous powder for injection.

Hematologic adverse events

• Very common (10% or more): Hemoglobin decreased (43%), neutrophil count decreased (41%), platelet count decreased (21%), anemia (21%)
• Common (1% to 10%): Hemolytic uremic syndrome^[Ref]

Immunologic

• Frequency not reported: Immunogenicity^[Ref]

Local

• Very common (10% or more): Infusion related reactions (e.g., chills, cough, dizziness, dyspnea, feeling hot, flushing, headache, hypertension, hypotension, infusion related reaction, myalgia, nausea, pyrexia, sinus tachycardia, tachycardia, vomiting, wheezing) (50%)^[Ref]

Musculoskeletal

• Very common (10% or more): Hypoalbuminemia (64%), fluid retention (63%), electrolyte abnormalities (57%), hypocalcemia (54%), hypophosphatemia (53%), hyponatremia (41%), peripheral edema (39%), hypokalemia (25%), hypomagnesemia (21%), hyperuricemia (21%)
• Common (1% to 10%): Weight gain, localized edema, fluid overload, fluid retention^[Ref]

Ocular

• Common (1% to 10%): Blurred vision, dry eye, cataracts, ocular discomfort and/or pain, ocular swelling/periorbital edema, conjunctivitis, conjunctival hemorrhage, ocular discharge^[Ref]

Hepatic

• Very common (10% or more): ALT increased (65%), AST increased (55%), blood bilirubin increased (30%), GGT increased (25%)^[Ref]

Respiratory

• Very common (10% or more): Cough, dyspnea, wheezing
• Common (1% to 10%): Pleural effusion^[Ref]

Other

• Very common (10% or more): Fatigue (34%), pyrexia (31%), alkaline phosphatase increased (20%), chills, feeling hot^[Ref]

Nervous system

• Very common (10% or more): Headache (33%), dizziness^[Ref]

Renal

• Very common (10% or more): Renal toxicity (e.g., acute kidney injury, renal impairment, renal failure, increased serum creatinine, proteinuria) (26%)^[Ref]

Cardiovascular

• Very common (10% or more): Capillary leak syndrome (34%), flushing, hypertension, hypotension, sinus tachycardia, tachycardia
• Common (1% to 10%): Pericardial effusion^[Ref]

Dermatologic

• Very common (10% or more): Facial edema (14%), abdominal distention (13%)^[Ref]

Gastrointestinal

• Very common (10% or more): Nausea (35%), constipation (23%), diarrhea (21%), vomiting
• Common (1% to 10%): Ascites^[Ref]

See also:

Frequently asked questions

• What type of drug is Lumoxiti?

Further information

Lumoxiti side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following this guide.

Medical Disclaimer