KG-Tuss HD Side Effects
Generic name: guaifenesin / hydrocodone / pseudoephedrine
Medically reviewed by Drugs.com. Last updated on Aug 9, 2024.
Note: This document provides detailed information about KG-Tuss HD Side Effects associated with guaifenesin / hydrocodone / pseudoephedrine. Some dosage forms listed on this page may not apply specifically to the brand name KG-Tuss HD.
Applies to guaifenesin / hydrocodone / pseudoephedrine: oral liquid.
Important warnings
This medicine can cause some serious health issues
MISUSE OF OPIOID MEDICINE CAN CAUSE ADDICTION, OVERDOSE, OR DEATH. Keep the medication in a place where others cannot get to it.
Fatal side effects can occur if you use this medicine with alcohol, or with other drugs that cause drowsiness or slow your breathing.
Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.
This medicine can slow or stop your breathing, and death may occur. A person caring for you should seek emergency medical attention if you have slow breathing with long pauses, blue colored lips, or if you are hard to wake up.
Stop using this medicine and call your doctor at once if you have:
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noisy breathing, sighing, shallow breathing;
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confusion, severe weakness or drowsiness;
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tremors, severe restlessness;
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a seizure;
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irregular heartbeats;
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severe headache, blurred vision, pounding in your neck or ears;
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a light-headed feeling, like you might pass out;
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severe constipation, stomach pain; or
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adrenal gland problems--nausea, vomiting, loss of appetite, dizziness, worsening tiredness or weakness.
Serious side effects may be more likely in older adults and those who are overweight, malnourished, or debilitated.
Common side effects may include:
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dizziness, drowsiness;
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headache;
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sleep problems (insomnia);
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nausea; or
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.
For healthcare professionals
Applies to guaifenesin/hydrocodone/pseudoephedrine: oral liquid, oral tablet.
General adverse events
The most common adverse events were sedation (somnolence, mental clouding, lethargy), impaired mental and physical performance, lightheadedness, dizziness, headache, dry mouth, nausea, vomiting, constipation, tachycardia, arrhythmias including premature ventricular contractions, CNS stimulation including anxiety, restlessness, nervousness, tremor, and irritability.[Ref]
Respiratory
- Frequency not reported: Bronchitis, cough, dyspnea, nasal congestion, nasopharyngitis, respiratory depression including fatal respiratory depression, sinusitis, upper respiratory tract infection
Cardiovascular
- Frequency not reported: Increased blood pressure, decreased blood pressure, tachycardia, chest pain, orthostatic hypotension, palpitations, syncope, prolonged QT interval, hot flush, atrial fibrillation, myocardial infarction, arrhythmias including premature ventricular contractions, flushing
Psychiatric
- Frequency not reported: Confusion, anxiety, dysphoria, agitation, addiction, abuse, misuse, fear, depression, hyperactivity, ataxia, hallucinations, hyperexcitability, opioid withdrawal syndrome, drug abuse, drug dependence
Nervous system
- Frequency not reported: Coma, ataxia, somnolence, facial dyskinesia, tremor, insomnia, migraine, increased intracranial pressure, seizure, dizziness, impaired mental and physical performance, serotonin syndrome
Serotonin syndrome has been reported with concomitant opioids and serotonergic drugs.
Gastrointestinal
- Frequency not reported: Abdominal pain, bowel obstruction, diarrhea, difficulty swallowing, GERD, indigestion, pancreatitis, paralytic ileus, dysgeusia, ischemic colitis, increase of serum amylase, dry mouth, biliary tract spasm (spasm of the sphincter of Oddi)
Dermatologic
- Frequency not reported: Hyperhidrosis, rash, pruritus, erythema, severe reactions such as acute generalized exanthematous pustulosis (AGEP)
Genitourinary
- Frequency not reported: Ureteral spasm, spasm of vesicle sphincters, urinary retention, urinary tract infection, hypogonadism, infertility
Endocrine
- Frequency not reported: Adrenal insufficiency, androgen deficiency
Adrenal insufficiency has been reported with opioid use, most often following greater than one month of use. Androgen deficiency has been reported with chronic opioid use.
Musculoskeletal
- Frequency not reported: Arthralgia, backache, muscle spasm
Ocular
- Frequency not reported: Miosis, visual disturbances
Metabolic
- Frequency not reported: Decreased appetite
See also:
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Mucinex D
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Ozempic
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Robitussin Nighttime Cough DM
Robitussin Nighttime Cough DM is used for cough, cough and nasal congestion
Vicks Nyquil Cough
Vicks Nyquil Cough is used for cough, cough and nasal congestion
Dextromethorphan/guaifenesin/phenylephrine
Dextromethorphan/guaifenesin/phenylephrine systemic is used for cough and nasal congestion
Brompheniramine/dextromethorphan/pseudoephedrine
Brompheniramine/dextromethorphan/pseudoephedrine systemic is used for cough and nasal congestion
References
1. (2017) "Product Information. Hycofenix (guaifenesin / hydrocodone / pseudoephedrine)." Mission Pharmacal Company
More about KG-Tuss HD (guaifenesin / hydrocodone / pseudoephedrine)
- Check interactions
- Compare alternatives
- Dosage information
- During pregnancy
- Drug class: upper respiratory combinations
Patient resources
Other brands
Entex HC, Hycofenix, Su-Tuss HD Elixir
Related treatment guides
Further information
KG-Tuss HD side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following this guide.