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Iodixanol Side Effects

For the Consumer

Applies to iodixanol: injection solution

In addition to its needed effects, some unwanted effects may be caused by iodixanol. In the event that any of these side effects do occur, they may require medical attention.

If any of the following side effects occur while taking iodixanol, check with your doctor or nurse immediately:

Less common:
  • Arm, back, or jaw pain
  • chest pain or discomfort
  • chest tightness or heaviness
  • fainting
  • fast or irregular heartbeat
  • nausea
  • shortness of breath
  • sweating
  • Agitation
  • blurred vision
  • chest pain or discomfort
  • coma
  • confusion
  • cough
  • decreased urine output
  • depression
  • difficulty breathing
  • dilated neck veins
  • dizziness
  • dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
  • extreme fatigue
  • fainting
  • feeling of warmth
  • headache
  • hostility
  • irregular breathing
  • irritability
  • lethargy
  • muscle twitching
  • noisy breathing
  • pain or discomfort in the arms, jaw, back, or neck
  • rapid weight gain
  • redness of the face, neck, arms, and occasionally, upper chest
  • seizures
  • severe or sudden headache
  • stupor
  • sudden loss of coordination
  • sudden slurring of speech
  • swelling of the face, ankles, or hands
  • swelling of the fingers, feet, or lower legs
  • vomiting
  • weight gain

Minor Side Effects

Some of the side effects that can occur with iodixanol may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:

Less common:
  • Bad, unusual, or unpleasant (after) taste
  • burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
  • change in taste
  • diarrhea
  • dizziness or lightheadedness
  • feeling of constant movement of self or surroundings
  • itching or skin rash
  • sensation of spinning
  • Acid or sour stomach
  • anxiety
  • back pain
  • belching
  • continuing ringing or buzzing or other unexplained noise in the ears
  • decreased awareness or responsiveness
  • dry mouth
  • general feeling of discomfort or illness
  • hearing loss
  • heartburn
  • hives or welts
  • hyperventilation
  • indigestion
  • redness of the skin
  • restlessness
  • severe sleepiness
  • shaking
  • stomach discomfort, upset, or pain
  • transient, mild, pleasant aromatic odor
  • trouble sleeping

For Healthcare Professionals

Applies to iodixanol: injectable solution


Serious reactions as well as fatalities are only seen on very rare occasions. Serious adverse reactions may include acute/chronic renal failure, anaphylactic or anaphylactoid shock, hypersensitivity reaction followed by cardiac reactions (Kounis' syndrome), cardiac or cardio-respiratory arrest and myocardial infarction.[Ref]


Very common (10% or more): Vaginal hemorrhage (intrathecal)
Uncommon (0.1% to 1%): Hematuria[Ref]


Common (1% to 10%): Angina pectoris, chest pain
Uncommon (0.1% to 1%): Arrhythmias, cardiac failure, conduction abnormalities, hypotension, myocardial infarction, flushing, peripheral ischemia.
Rare (0.01% to 0.1%): Hypotension
Very rare (less than 0.01%): Hypertension, ischemia
Frequency not reported: Ventricular hypokinesia, myocardial ischemia, arterial spasm, thrombosis, thrombophlebitis, thrombocytopenia, cardiorespiratory arrest, spasm of coronary arteries, shock[Ref]


Common (1% to 10%): Nonurticarial rash, erythema, pruritus, rash, urticaria
Uncommon (0.1% to 1%): Hematoma, increased sweating
Very rare (less than 0.01%): Angioedema
Frequency not reported: Severe pustular or bullous skin reactions, Stevens-Johnson syndrome, erythema multiforme, toxic epidermal necrolysis, acute generalized exanthematous pustulosis, drug rash with eosinophilia and systemic symptoms, drug eruption, dermatitis allergic, skin exfoliation[Ref]


Common (1% to 10%): Nausea
Uncommon (0.1% to 1%): Diarrhea, vomiting, dyspepsia
Very rare (less than 0.01%): Abdominal pain, abdominal discomfort
Frequency not reported: Acute pancreatitis, pancreatitis aggravated, salivary gland enlargement[Ref]


Common (1% to 10%): Injection site pain[Ref]

Nervous system

Common (1% to 10%): Headache, migraine, paresthesia
Uncommon (0.1% to 1%): Nervousness, dizziness, sensory disturbance, syncope, parosmia, cerebral vascular disorder, convulsions, hypoesthesia, stupor
Very rare (less than 0.01%): Cerebrovascular accident, amnesia
Frequency not reported: Disturbances in consciousness, coma, motor dysfunction, transient contrast induced encephalopathy (including hallucination), tremor
Postmarketing reports: Dyskinesia[Ref]


Common (1% to 10%): Scotoma
Uncommon (0.1% to 1%): Abnormal vision
Frequency not reported: Transient blindness[Ref]


Common (1% to 10%): Vertigo
Uncommon (0.1% to 1%): Edema, fatigue, malaise, tinnitus, feeling hot
Rare (0.01% to 0.1%): Pain, pyrexia, shivering (chills), administration site reactions including
Very rare (less than 0.01%): Feeling cold, asthenic conditions
Frequency not reported: Iodism[Ref]


Hypersensitivity reactions usually present as respiratory or cutaneous symptoms like dyspnea, rash, erythema, urticaria, pruritus, skin reaction, angioneurotic edema, hypotension, fever, laryngeal edema, bronchospasm or pulmonary edema. They may appear either immediately after the injection or up to a few days later.
Hypersensitivity reactions may occur irrespectively of the dose and mode of administration and mild symptoms may represent the first signs of a serious anaphylactoid reaction/shock.[Ref]

Uncommon (0.1% to 1%): Pharyngeal edema
Frequency not reported: Anaphylactoid reaction, anaphylactoid shock[Ref]


Uncommon (0.1% to 1%): Agitation, anxiety, insomnia, confusion[Ref]


Uncommon (0.1% to 1%): Abnormal renal function, acute renal failure[Ref]


Uncommon (0.1% to 1%): Asthma, bronchitis, dyspnea, pulmonary edema, rhinitis
Rare (less than 0.1%): Cough
Frequency not reported: Non-cardiogenic pulmonary edema, respiratory arrest, respiratory failure
Postmarketing reports: Pulmonary embolism, respiratory depression[Ref]


Rare (less than 0.1%): Back pain
Frequency not reported: Arthralgia
Postmarketing reports: Polymyalgia rheumatica[Ref]


Postmarketing reports: Hemorrhage[Ref]


Postmarketing reports: Hypoglycemia[Ref]


1. Cerner Multum, Inc. "Australian Product Information." O 0

2. "Product Information. Visipaque (iodixanol)." Nycomed Inc, Princeton, NJ.

3. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0

Not all side effects for iodixanol may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.