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Iodixanol Side Effects

Medically reviewed by Last updated on Jun 7, 2023.

Applies to iodixanol: injection solution.


Injection route (Solution)

Not for Intrathecal UseInadvertent intrathecal administration may cause death, convulsions/seizures, cerebral hemorrhage, coma, paralysis, arachnoiditis, acute renal failure, cardiac arrest, rhabdomyolysis, hyperthermia, and brain edema.

Serious side effects of Iodixanol

Along with its needed effects, iodixanol may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur while taking iodixanol:

Less common


Incidence not known

Other side effects of Iodixanol

Some side effects of iodixanol may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common


Incidence not known

For Healthcare Professionals

Applies to iodixanol: injectable solution.


Serious reactions as well as fatalities are only seen on very rare occasions. Serious adverse reactions may include acute/chronic renal failure, anaphylactic or anaphylactoid shock, hypersensitivity reaction followed by cardiac reactions (Kounis' syndrome), cardiac or cardio-respiratory arrest and myocardial infarction.[Ref]


Very common (10% or more): Vaginal hemorrhage (intrathecal)

Uncommon (0.1% to 1%): Hematuria[Ref]


Common (1% to 10%): Angina pectoris, chest pain

Uncommon (0.1% to 1%): Arrhythmias, cardiac failure, conduction abnormalities, hypotension, myocardial infarction, flushing, peripheral ischemia.

Rare (0.01% to 0.1%): Hypotension

Very rare (less than 0.01%): Hypertension, ischemia

Frequency not reported: Ventricular hypokinesia, myocardial ischemia, arterial spasm, thrombosis, thrombophlebitis, thrombocytopenia, cardiorespiratory arrest, spasm of coronary arteries, shock[Ref]


Common (1% to 10%): Nonurticarial rash, erythema, pruritus, rash, urticaria

Uncommon (0.1% to 1%): Hematoma, increased sweating

Very rare (less than 0.01%): Angioedema

Frequency not reported: Severe pustular or bullous skin reactions, Stevens-Johnson syndrome, erythema multiforme, toxic epidermal necrolysis, acute generalized exanthematous pustulosis, drug rash with eosinophilia and systemic symptoms, drug eruption, dermatitis allergic, skin exfoliation[Ref]


Common (1% to 10%): Nausea

Uncommon (0.1% to 1%): Diarrhea, vomiting, dyspepsia

Very rare (less than 0.01%): Abdominal pain, abdominal discomfort

Frequency not reported: Acute pancreatitis, pancreatitis aggravated, salivary gland enlargement[Ref]


Common (1% to 10%): Injection site pain[Ref]

Nervous system

Common (1% to 10%): Headache, migraine, paresthesia

Uncommon (0.1% to 1%): Nervousness, dizziness, sensory disturbance, syncope, parosmia, cerebral vascular disorder, convulsions, hypoesthesia, stupor

Very rare (less than 0.01%): Cerebrovascular accident, amnesia

Frequency not reported: Disturbances in consciousness, coma, motor dysfunction, transient contrast induced encephalopathy (including hallucination), tremor

Postmarketing reports: Dyskinesia[Ref]


Common (1% to 10%): Scotoma

Uncommon (0.1% to 1%): Abnormal vision

Frequency not reported: Transient blindness[Ref]


Common (1% to 10%): Vertigo

Uncommon (0.1% to 1%): Edema, fatigue, malaise, tinnitus, feeling hot

Rare (0.01% to 0.1%): Pain, pyrexia, shivering (chills), administration site reactions including


Very rare (less than 0.01%): Feeling cold, asthenic conditions

Frequency not reported: Iodism[Ref]


Uncommon (0.1% to 1%): Pharyngeal edema

Frequency not reported: Anaphylactoid reaction, anaphylactoid shock[Ref]

Hypersensitivity reactions usually present as respiratory or cutaneous symptoms like dyspnea, rash, erythema, urticaria, pruritus, skin reaction, angioneurotic edema, hypotension, fever, laryngeal edema, bronchospasm or pulmonary edema. They may appear either immediately after the injection or up to a few days later.

Hypersensitivity reactions may occur irrespectively of the dose and mode of administration and mild symptoms may represent the first signs of a serious anaphylactoid reaction/shock.[Ref]


Uncommon (0.1% to 1%): Agitation, anxiety, insomnia, confusion[Ref]


Uncommon (0.1% to 1%): Abnormal renal function, acute renal failure[Ref]


Uncommon (0.1% to 1%): Asthma, bronchitis, dyspnea, pulmonary edema, rhinitis

Rare (less than 0.1%): Cough

Frequency not reported: Non-cardiogenic pulmonary edema, respiratory arrest, respiratory failure

Postmarketing reports: Pulmonary embolism, respiratory depression[Ref]


Rare (less than 0.1%): Back pain

Frequency not reported: Arthralgia

Postmarketing reports: Polymyalgia rheumatica[Ref]


Postmarketing reports: Hemorrhage[Ref]


Postmarketing reports: Hypoglycemia[Ref]


1. Product Information. Visipaque (iodixanol). Nycomed Inc. 2001;PROD.

2. Cerner Multum, Inc. UK Summary of Product Characteristics.

3. Cerner Multum, Inc. Australian Product Information.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.