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Hydroxyamphetamine / tropicamide ophthalmic Side Effects

For the Consumer

Applies to hydroxyamphetamine / tropicamide ophthalmic: ophthalmic solution

In addition to its needed effects, some unwanted effects may be caused by hydroxyamphetamine / tropicamide ophthalmic. In the event that any of these side effects do occur, they may require medical attention.

Major Side Effects

You should check with your doctor immediately if any of these side effects occur when taking hydroxyamphetamine / tropicamide ophthalmic:

  • Blurred vision
  • chest pain or discomfort
  • confusion
  • dizziness
  • faintness or lightheadedness when getting up from a lying or sitting position
  • fast, slow, or irregular heartbeat
  • nausea
  • pain or discomfort in arms, jaw, back or neck
  • shortness of breath
  • sudden sweating
  • unusual tiredness or weakness
Frequency of side effects not known
  • Agitation
  • anxiety
  • cold, clammy, pale skin
  • cough
  • difficulty swallowing
  • eye pain
  • failure to recognize people
  • hives
  • irritability
  • itching
  • hyperactivity or restlessness
  • loss of consciousness
  • loss of vision
  • mood or mental changes
  • nervousness
  • nightmares
  • pounding heartbeat or pulse
  • puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
  • seeing, hearing, or feeling things that are not there
  • skin rash
  • tightness in chest
  • tremor
  • unusual behavior such as disorientation to time or place
  • unusual feeling of excitement
  • wheezing
Symptoms of overdose:

If any of the following symptoms of overdose occur while taking hydroxyamphetamine / tropicamide ophthalmic, get emergency help immediately:

  • Bloating
  • blurred vision
  • chest pain or discomfort
  • diarrhea
  • dizziness
  • enlarged pupils
  • fainting
  • fast, slow, or irregular heartbeat
  • gas
  • headache
  • heartburn
  • indigestion
  • lightheadedness
  • loss of appetite
  • nausea
  • nervousness
  • pounding in the ears
  • pounding or rapid pulse
  • stomach pain
  • sweating
  • vomiting

Minor Side Effects

Some of the side effects that can occur with hydroxyamphetamine / tropicamide ophthalmic may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:

Frequency of side effects not known
  • Change in color vision
  • difficulty seeing at night
  • dry mouth
  • headache
  • increased sensitivity of eyes to sunlight
  • muscle stiffness or tightness
  • temporary stinging in the eyes

For Healthcare Professionals

Applies to hydroxyamphetamine / tropicamide ophthalmic: ophthalmic solution


Transient stinging, dry mouth, blurred vision, photophobia with or without corneal staining, tachycardia, headache, allergic reactions, nausea, vomiting, pallor, and muscle rigidity have been reported following use of tropicamide and/or hydroxyamphetamine hydrobromide and thus may occur with the combination product. Rare but serious cardiovascular events (including death due to myocardial infarction, ventricular fibrillation, and significant hypotensive episodes) have occurred shortly following instillation of this drug.[Ref]


Frequency not reported: Intraocular pressure increased, vision blurred, photophobia, corneal staining, transient stinging[Ref]


Frequency not reported: Myocardial infarction, ventricular fibrillation, hypotension, tachycardia, vasomotor collapse, cardiorespiratory collapse[Ref]


Frequency not reported: Dry mouth, nausea, vomiting[Ref]


Frequency not reported: Allergic reaction[Ref]


Frequency not reported: Muscle rigidity[Ref]

Nervous system

Frequency not reported: Headache, central nervous system disturbed[Ref]


Frequency not reported: Psychotic reaction, behavior disturbed[Ref]


Frequency not reported: Pallor[Ref]


1. "Product Information. Paremyd (hydroxyamphetamine-tropicamide ophthalmic)." Akorn Inc, Buffalo Grove, IL.

Not all side effects for hydroxyamphetamine / tropicamide ophthalmic may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.