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Hextend Side Effects

Generic name: hetastarch

Medically reviewed by Last updated on April 19, 2021.

Note: This document contains side effect information about hetastarch. Some of the dosage forms listed on this page may not apply to the brand name Hextend.

For the Consumer

Applies to hetastarch: parenteral injection


  • Increased mortality and/or severe renal injury requiring renal replacement therapy reported in critically ill adults, including patients with sepsis.100 104 106 Do not use in such patients.100 104 106 (See Contraindications and also see Increased Mortality and Severe Renal Injury under Cautions.)

Side effects include:

Hypersensitivity reactions, coagulopathy, hemodilution, circulatory overload, metabolic acidosis, CHF, pulmonary edema, bleeding, vomiting, peripheral edema, submaxillary and parotid glandular enlargement, mild influenza-like symptoms, headache, muscle pain.

For Healthcare Professionals

Applies to hetastarch: intravenous solution


Frequency not reported: Circulatory overload, congestive heart failure, pulmonary edema, peripheral edema of the lower extremities[Ref]


Frequency not reported: Vomiting[Ref]


Frequency not reported: Intracranial bleeding, bleeding and/or anemia due to hemodilution and/or Factor VIII deficiency, acquired von Willebrand's-like syndrome, coagulopathy (including rare cases of disseminated intravascular coagulopathy and hemolysis)[Ref]


Frequency not reported: Death, life-threatening anaphylactic/anaphylactoid reactions, cardiac arrest, ventricular fibrillation, severe hypotension, non-cardiac pulmonary edema, laryngeal edema, bronchospasm, angioedema, wheezing, restlessness, tachypnea, stridor, fever, chest pain, bradycardia, tachycardia, shortness of breath, chills, urticaria, pruritus, facial and periorbital edema, coughing, sneezing, flushing erythema multiforme, rash[Ref]


Frequency not reported: Metabolic acidosis[Ref]


Frequency not reported: Muscle pain[Ref]


Frequency not reported: Submaxillary and parotid glandular enlargement, mild influenza-like symptoms, headaches, hydroxyethyl starch-associated pruritus in patients with deposits of hydroxyethyl starch in peripheral nerves[Ref]


Frequency not reported: Pulmonary edema[Ref]


-The most common adverse reactions are hypersensitivity, coagulopathy, hemodilution, circulatory overload and metabolic acidosis.

-Serious adverse events reported in clinical trials are increased mortality and renal replacement therapy in critically ill patients.[Ref]


Frequency not reported: Need for renal replacement therapy[Ref]


1. "Product Information. Hextend (hetastarch)." Abbott Pharmaceutical, Abbott Park, IL.

2. "Product Information. Hespan (hetastarch)." B. Braun Medical, Irvine, CA.

More about Hextend (hetastarch)

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Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.