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Guaifenex DM Side Effects

Generic Name: dextromethorphan / guaifenesin

Note: This document contains side effect information about dextromethorphan / guaifenesin. Some of the dosage forms listed on this page may not apply to the brand name Guaifenex DM.

For the Consumer

Applies to dextromethorphan / guaifenesin: oral capsule, oral liquid, oral packet, oral solution, oral syrup, oral tablet, oral tablet extended release 12 hour

What are some side effects that I need to call my doctor about right away?

WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect:

  • Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.

What are some other side effects of this drug?

All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if you have any side effects that bother you or do not go away.

These are not all of the side effects that may occur. If you have questions about side effects, call your doctor. Call your doctor for medical advice about side effects.

You may report side effects to the FDA at 1-800-FDA-1088. You may also report side effects at http://www.fda.gov/medwatch.

For Healthcare Professionals

Applies to dextromethorphan / guaifenesin: oral capsule, oral capsule extended release, oral elixir, oral granule, oral liquid, oral suspension extended release, oral tablet, oral tablet extended release

Nervous system

Nervous system side effects of dextromethorphan have included drowsiness and dizziness. Adverse effects, which have occurred at higher doses, include excitation, mental confusion, and opioid like respiratory depression. In some cases of abuse, patients have experienced euphoria, hyperactivity, mania, and auditory and visual hallucinations.[Ref]

Gastrointestinal

Gastrointestinal side effects have included nausea, vomiting and constipation.[Ref]

Dermatologic

Dermatologic side effects have included pruritus and rash.[Ref]

Hypersensitivity

Hypersensitivity side effects of dextromethorphan have included fixed-drug eruptions.[Ref]

References

1. Hall RC, Beresford TP, Stickney SK, Nasdahl CS, Coleman JH "Psychiatric reactions produced by respiratory drugs." Psychosomatics 26 (1985): 605-8,616-7

2. Covington TR, Lawson LC, Young LL, eds. "Handbook of Nonprescription Drugs. 10th ed." Washington, DC: American Pharmaceutical Association (1993):

3. Wolfe TR, Caravati EM "Massive dextromethorphan ingestion and abuse." Am J Emerg Med 13 (1995): 174-6

4. Helfer J, Kim OM "Psychoactive abuse potential of Robitussin-DM." Am J Psychiatry 147 (1990): 672-3

5. "Product Information. Tussi-Organidin DM NR (dextromethorphan-guaifenesin)" Wallace Laboratories, Cranbury, NJ.

6. Bostwick JM "Dextromethorphan-induced manic symptoms in a bipolar patient on lithium." Psychosomatics 37 (1996): 571-2

7. Murray S, Brewerton T "Abuse of over-the-counter dextromethorphan by teenagers." South Med J 86 (1993): 1151-3

8. Polles A, Griffith JL "Dextromethorphan-induced mania." Psychosomatics 37 (1996): 71-4

9. Stubb S, Reitamo S "Fixed-drug eruption due to dextromethorphan ." Arch Dermatol 126 (1990): 970-1

Some side effects of Guaifenex DM may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. Drugs.com does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.

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