Gonal-f RFF Side Effects
Generic Name: follicle stimulating hormone
Medically reviewed by Drugs.com. Last updated on June 28, 2020.
Note: This document contains side effect information about follicle stimulating hormone. Some of the dosage forms listed on this page may not apply to the brand name Gonal-f RFF.
Common side effects of Gonal-f RFF include: abdominal distention. Other side effects include: ovarian hyperstimulation syndrome. See below for a comprehensive list of adverse effects.
For the Consumer
Applies to follicle stimulating hormone: subcutaneous powder for solution, subcutaneous solution
Other dosage forms:
Side effects requiring immediate medical attention
Along with its needed effects, follicle stimulating hormone (the active ingredient contained in Gonal-f RFF) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Stop taking follicle stimulating hormone and get emergency help immediately if any of the following effects occur:
Check with your doctor as soon as possible if any of the following side effects occur while taking follicle stimulating hormone:
For patients treated for female infertility or patients pretreated with a gonadotropin-releasing hormone agonist (GnRHa) undergoing assisted reproduction technologies (ART)
- Abdominal bloating
- flu or cold-like symptoms, such as body aches or pain, coughing, fever, headache, loss of voice, runny nose, and unusual tiredness or weakness
- passing of gas
- vaginal bleeding between menstrual periods
For patients treated for female infertility
- breast pain or tenderness
- mood swings
For patients treated for female infertility or patients pretreated with GnRHa undergoing ART
- painful menstrual periods
- redness, pain, or swelling at injection site
- vaginal bleeding unrelated to menstrual periods (heavy)
- white vaginal discharge
For patients treated for female infertility
- migraine headache
- stomach discomfort
For patients treated pretreated with a GnRHa undergoing ART
- Fast, racing heartbeat
- itching of skin
- loss of appetite
- thirst (unusual)
After you stop using this medicine, it may still produce some side effects that need attention. During this period of time, Check with your doctor immediately if you notice the following side effects:
- Abdominal pain (severe), nausea, vomiting, and weight gain (rapid)
For Healthcare Professionals
Applies to follicle stimulating hormone: injectable powder for injection, injectable solution, subcutaneous powder for injection, subcutaneous solution
Very common (10% or more): Multiple births (up to 35.1%), ovarian cysts, mild to moderate ovarian enlargement
Common (1% to 10%): Mild or moderate OHSS (including symptomatology), intermenstrual bleeding, pelvic discomfort, ovarian hyperstimulation, ectopic pregnancy, miscarriage, gynecomastia (males), varicocele, epididymal cyst, vaginal hemorrhage, pelvic pain
Uncommon (0.1% to 1%): Severe OHSS (including symptomatology), breast complaints, metrorrhagia, ovarian cyst, ovarian enlargement, ovarian torsion, uterine enlargement, vaginal hemorrhage
Rare (less than 0.1%): Complications of severe OHSS, adnexal torsion associated with ovarian enlargement
Frequency not reported: Ectopic pregnancy, miscarriage, multiple gestations
Postmarketing reports: Breast tenderness[Ref]
Very common (10% or more): Abdominal pain (up to 23.2%), abdomen enlarged (13.9%)
Uncommon (0.1% to 1%): Swollen abdomen[Ref]
Very common (10% or more): Headache (up to 26.5%), dizziness
Common (1% to 10%): Fatigue[Ref]
Very common (10% or more): Injection site reactions (e.g. pain, erythema, hematoma, swelling and/or irritation at the site of injection)[Ref]
Common (1% to 10%): Acne, rash, dermoid cyst
Common (1% to 10%): Weight gain[Ref]
Uncommon (0.1% to 1%): Generalized hypersensitivity reaction
Very rare (less than 0.01%): Mild to severe hypersensitivity reactions including anaphylactic reactions and shock[Ref]
1. "Product Information. Follistim (follicle stimulating hormone)." Organon, West Orange, NJ.
2. Cerner Multum, Inc. "Australian Product Information." O 0
3. "Product Information. Gonal-F (follicle stimulating hormone)." Serono Laboratories Inc, Norwell, MA.
4. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
More about Gonal-f RFF (follicle stimulating hormone)
- During Pregnancy
- Dosage Information
- Drug Interactions
- Pricing & Coupons
- En Español
- Drug class: gonadotropins
Related treatment guides
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Some side effects may not be reported. You may report them to the FDA.