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Gamulin Rh Side Effects

Generic name: rho (d) immune globulin

Medically reviewed by Last updated on Sep 10, 2023.

Note: This document contains side effect information about rho (d) immune globulin. Some dosage forms listed on this page may not apply to the brand name Gamulin Rh.

Applies to rho (d) immune globulin: solution.


Intravenous route (Powder for Solution; Solution)

Intravascular hemolysis (IVH) leading to death has been reported in patients treated for immune thrombocytopenic purpura (ITP) with Rho(D) immune globulin. IVH can lead to clinically compromising anemia and multi-system organ failure, including acute respiratory distress syndrome (ARDS), acute renal insufficiency, renal failure, and disseminated intravascular coagulation (DIC). Alert patients and closely monitor for the signs and symptoms of IVH in a health care setting for at least 8 hours after administration for ITP. Perform a dipstick urinalysis at baseline, 2 hours, 4 hours after administration, and prior to the end of the monitoring period. If signs and/or symptoms of IVH are present or suspected, post-treatment laboratory tests should be performed.

Serious side effects of Gamulin Rh

Along with its needed effects, rho (d) immune globulin (the active ingredient contained in Gamulin Rh) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur while taking rho (d) immune globulin:


Other side effects of Gamulin Rh

Some side effects of rho (d) immune globulin may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common

For Healthcare Professionals

Applies to rho (d) immune globulin: injectable powder for injection, injectable solution, intramuscular powder for injection, intramuscular solution.


Very common (10% or more): Chills (34.7%), pyrexia/increased body temperature (32.6%)

Uncommon (0.1% to 1%): Malaise

Very rare (less than 0.01%): Death

Frequency not reported: Shivering, weakness

Postmarketing reports: Chest pain, fatigue, edema[Ref]


Very rare (less than 0.01%): Disseminated intravascular coagulation

Frequency not reported: Intravascular hemolysis, hemolysis resulting in death, clinically compromising anemia, extravascular hemolysis, hemolytic reaction

Postmarketing reports: Hemoglobinemia, disseminated intravascular coagulation[Ref]

Hemolytic reaction includes hypotension, nausea, chills, headache, and a decrease in haptoglobin and hemoglobin.[Ref]


Uncommon (0.1% to 1%): Injection site swelling, injection site pain

Rare (less than 0.1%): Injection site erythema, injection site induration, injection site warmth, injection site pruritus, injection site rash[Ref]

Nervous system

Very common (10% or more): Headache (14.3%)

Uncommon (0.1% to 1%): Dizziness, vertigo[Ref]


Uncommon (0.1% to 1%): Nausea, vomiting

Rare (less than 0.1%): Diarrhea[Ref]


Rare (less than 0.1%): Tachycardia, hypotension

Frequency not reported: Increase in blood pressure

Postmarketing reports: Cardiac arrest, cardiac failure, myocardial infarction[Ref]


Uncommon (0.1% to 1%): Skin reaction, erythema, pruritus, pallor, rash

Postmarketing reports: Hyperhidrosis[Ref]


Rare (less than 0.1%): Arthralgia, back pain

Postmarketing reports: Myalgia, muscle spasm, pain in extremities[Ref]


Very common (10% or more): Increase in blood bilirubin (21.4%)

Postmarketing reports: Jaundice[Ref]


Rare (less than 0.1%): Hypersensitivity, anaphylactic shock, anaphylactic reaction[Ref]


The most common adverse events were chills, pyrexia, increased bilirubin, and headache.[Ref]


Rare (less than 0.1%): Dyspnea

Postmarketing reports: Acute respiratory distress syndrome, transfusion related acute lung injury[Ref]


Frequency not reported: Acute renal insufficiency

Postmarketing reports: Renal failure, renal impairment[Ref]


Uncommon (0.1% to 1%): Transient positive anti-C antibody test

Frequency not reported: Sensitization to repeated injections of human globulin[Ref]


Postmarketing reports: Hemoglobinuria, anuria, chromaturia, hematuria[Ref]


1. (2022) "Product Information. WinRho SDF (RHo (D) immune globulin)." Apothecon Inc

2. (2022) "Product Information. Rhophylac (RHo (D) immune globulin)." Apothecon Inc

3. (2022) "Product Information. HyperRHO S/D Full Dose (RHo (D) immune globulin)." Talecris Biotherapeutics

4. Cerner Multum, Inc. "UK Summary of Product Characteristics."

5. Cerner Multum, Inc. "Australian Product Information."

6. (2022) "Product Information. RhoGAM Ultra-Filtered Plus (RHo (D) immune globulin)." Kedrion Biopharma Inc

7. "Product Information. BayRHo-D (RHo (D) immune globulin)." Bayer

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.