Florexa Side Effects

Generic name: eflornithine topical

Medically reviewed by Drugs.com. Last updated on Feb 5, 2025.

Note: This document provides detailed information about Florexa Side Effects associated with eflornithine topical. Some dosage forms listed on this page may not apply specifically to the brand name Florexa.

Applies to eflornithine topical: topical cream.

Important warnings This medicine can cause some serious health issues

Follow all directions on your medicine label and package.

Tell each of your healthcare providers about all your medical conditions, allergies, and all medicines you use.

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Stop using eflornithine and call your doctor at once if you have:

• severe irritation of treated skin; or

• redness or crusting around your hair follicles.

Common side effects may include:

• temporary redness, rash, burning, stinging, itching, or tingling;

• acne or red bumps on the skin;

• skin dryness; or

• headache.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.

For healthcare professionals

Applies to eflornithine topical: topical cream.

General adverse events

The most frequently reported side effects were dermatologic in nature and included acne and pseudofolliculitis barbae.^[Ref]

Dermatologic

• Very common (10% or more): Acne (up to 21.3 %), pseudofolliculitis barbae (up to 16.3%)
• Common (1% to 10%): Stinging skin, burning skin, dry skin, pruritus, erythema, tingling skin, skin irritated, rash, alopecia
• Uncommon (0.1% to 1%): Ingrown hair, papular rash, skin bleeding, eczema, contact dermatitis, hair texture abnormal, hair growth abnormal, skin hypopigmentation, skin soreness
• Rare (less than 0.1%): Rosacea, seborrheic dermatitis, maculopapular rash, skin cyst, vesiculobullous rash, skin disorder, hirsutism, skin tightness^[Ref]

Nervous system

• Common (1% to 10%): Headache, dizziness
• Frequency not reported: Numbness^[Ref]

Gastrointestinal

• Common (1% to 10%): Dyspepsia
• Uncommon (0.1% to 1%): Nausea, cheilitis, numb lip
• Frequency not reported: Swollen lip^[Ref]

Cardiovascular

• Uncommon (0.1% to 1%): Flushing^[Ref]

Other

• Common (1% to 10%): Folliculitis
• Uncommon (0.1% to 1%): Facial edema, asthenia, vertigo, mouth edema, herpes simplex, furunculosis^[Ref]

Metabolic

• Uncommon (0.1% to 1%): Anorexia^[Ref]

Oncologic

• Rare (less than 0.1%): Skin neoplasm^[Ref]

Further information

Florexa side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following this guide.

Medical Disclaimer