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Finasteride / tadalafil Side Effects

Medically reviewed by Drugs.com. Last updated on May 30, 2023.

Applies to finasteride / tadalafil: oral capsule.

Serious side effects

Along with its needed effects, finasteride/tadalafil may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking finasteride / tadalafil:

More common

Less common

Incidence not known

Other side effects

Some side effects of finasteride / tadalafil may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

Less common

Rare

Incidence not known

For Healthcare Professionals

Applies to finasteride / tadalafil: oral capsule.

Cardiovascular

Common (1% to 10%):

-Finasteride: Hypotension, postural hypotension

Frequency not reported:

-Tadalafil: Angina pectoris, chest pain, hypotension, myocardial infarction, palpitations, postural hypotension, syncope, tachycardia

Postmarketing reports:

-Tadalafil: Stroke, sudden cardiac death[Ref]

Dermatologic

Uncommon (0.1% to 1%):

-Finasteride: Rash

-Tadalafil: Pruritus, rash, sweating

Postmarketing reports:

-Finasteride: Angioedema (including swelling of the lips, tongue, throat, and face), pruritus, urticaria

-Tadalafil: Exfoliative dermatitis, Stevens-Johnson syndrome, urticaria[Ref]

Gastrointestinal

Common (1% to 10%):

-Tadalafil: Dyspepsia, diarrhea

Frequency not reported:

-Tadalafil: Abnormal liver function tests, dry mouth, dysphagia, esophagitis, gastritis, gastroesophageal reflux disease, GGTP increased, hemorrhoidal hemorrhage, loose stools, nausea, rectal hemorrhage, upper abdominal pain, vomiting[Ref]

General

The most frequently reported adverse reactions in studies evaluating finasteride in monotherapy or in combination therapy were related to sexual function.[Ref]

Genitourinary

Common (1% to 10%):

-Finasteride: Abnormal ejaculation, decreased volume of ejaculate

Frequency not reported:

-Tadalafil: Erection increased, spontaneous penile erection

Postmarketing reports:

-Finasteride: Testicular pain

-Tadalafil: Priapism[Ref]

Musculoskeletal

Common (1% to 10%):

-Tadalafil: Back pain, myalgia, pain in extremity

Frequency not reported:

-Tadalafil: Arthralgia, muscle spasm, neck pain[Ref]

Ocular

Frequency not reported:

-Tadalafil: Blurred vision, changes in color vision, conjunctivitis (including conjunctival hyperemia), eye pain, increased lacrimation, swelling of eyelids

Postmarketing reports:

-Tadalafil: Non-arteritic anterior ischemic optic neuropathy (NAION), retinal artery occlusion, retinal vein occlusion, visual field defect[Ref]

Other

Common (1% to 10%):

-Finasteride: Abnormal sexual function, asthenia, breast enlargement, decreased libido, gynecomastia, impotence, peripheral edema

Uncommon (0.1% to 1%):

-Finasteride: Breast tenderness

Frequency not reported:

-Tadalafil: Asthenia, face edema, fatigue, pain, peripheral edema, sudden decrease or loss of hearing, tinnitus

Postmarketing reports:

-Finasteride: Decreased libido and ejaculation disorders (e.g. reduced ejaculate volume),

hematospermia, male breast cancer, male infertility and/or poor seminal quality, sexual dysfunction that continued after discontinuation of treatment including erectile dysfunction

-Tadalafil: Sudden decrease or loss of hearing[Ref]

Renal

Frequency not reported:

-Tadalafil: Renal impairment[Ref]

Respiratory

Common (1% to 10%):

-Tadalafil: Nasopharyngitis

Uncommon (0.1% to 1%):

-Finasteride: Dyspnea, rhinitis

Frequency not reported:

-Tadalafil: Dyspnea, epistaxis, pharyngitis[Ref]

Nervous system

Common (1% to 10%):

-Finasteride: Dizziness, headache, somnolence

-Tadalafil: Dizziness, headache

Frequency not reported:

-Tadalafil: Hypesthesia, insomnia, paresthesia, somnolence, vertigo

Postmarketing reports:

-Finasteride: Depression

-Tadalafil: Migraine, seizure and seizure recurrence, transient global amnesia[Ref]

References

1. Product Information. Entadfi (finasteride-tadalafil). Veru Inc. 2021.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.