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Factor XIII Side Effects

For the Consumer

Applies to factor XIII: intravenous powder for solution

Along with its needed effects, factor XIII may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur while taking factor XIII:

More common
  • Bloody nose
  • bruise
  • collection of blood under the skin
  • deep, dark purple bruise
  • fever
  • itching, pain, redness, or swelling
Incidence not known
  • Chest pain
  • cough
  • dizziness or fainting
  • hives
  • pain in the chest, groin, or legs, especially the calves
  • puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
  • red, scaly, swollen, or peeling areas of the skin
  • severe, sudden headache
  • shortness of breath
  • tenderness, pain, swelling, warmth, skin discoloration, and prominent superficial veins over the affected area
  • unusual tiredness or weakness

Some side effects of factor XIII may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common
  • Difficulty with moving
  • general feeling of discomfort or illness
  • headache
  • joint pain
  • muscle aches and pains

For Healthcare Professionals

Applies to factor XIII: intravenous powder for injection


Hypersensitivity side effects have included allergy, rash, pruritus, and erythema, chills/rise in temperature, arthralgia, headache, elevated thrombin antithrombin levels, and an increase in hepatic enzymes.[Ref]


Hematologic side effects have included factor XIII inhibitor formation.[Ref]


Cardiovascular side effects have included thrombosis and embolism.[Ref]


General side effects have included flu-like syndrome and pyrexia.[Ref]


Gastrointestinal side effects have included abdominal pain, diarrhea and vomiting.[Ref]


Musculoskeletal side effects have included contusion, joint injury, limb injury, road traffic accident, and arthralgia.[Ref]


Respiratory side effects have included upper respiratory tract infection and epistaxis.[Ref]

Nervous system

Nervous system side effects have included headache and head injury.[Ref]


Immunologic side effects have included allergic/anaphylactic reaction (including cutaneous reactions, alteration in blood pressure, nausea, dyspnea, fever, and chills).[Ref]


1. "Product Information. Corifact (factor XIII)." CSL Behring, King of Prussia, PA.

Some side effects of factor XIII may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.