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Factor XIII Side Effects

For the Consumer

Applies to factor XIII: intravenous powder for solution

In addition to its needed effects, some unwanted effects may be caused by factor XIII. In the event that any of these side effects do occur, they may require medical attention.

If any of the following side effects occur while taking factor XIII, check with your doctor or nurse immediately:

More common:
  • Bloody nose
  • bruise
  • collection of blood under the skin
  • deep, dark purple bruise
  • fever
  • itching, pain, redness, or swelling
Incidence not known:
  • Chest pain
  • cough
  • dizziness or fainting
  • hives
  • pain in the chest, groin, or legs, especially the calves
  • puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
  • red, scaly, swollen, or peeling areas of the skin
  • severe, sudden headache
  • shortness of breath
  • tenderness, pain, swelling, warmth, skin discoloration, and prominent superficial veins over the affected area
  • unusual tiredness or weakness

Minor Side Effects

Some of the side effects that can occur with factor XIII may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:

More common:
  • Difficulty with moving
  • general feeling of discomfort or illness
  • headache
  • joint pain
  • muscle aches and pains

For Healthcare Professionals

Applies to factor XIII: intravenous powder for injection


Hypersensitivity side effects have included allergy, rash, pruritus, and erythema, chills/rise in temperature, arthralgia, headache, elevated thrombin antithrombin levels, and an increase in hepatic enzymes.[Ref]


Hematologic side effects have included factor XIII inhibitor formation.[Ref]


Cardiovascular side effects have included thrombosis and embolism.[Ref]


General side effects have included flu-like syndrome and pyrexia.[Ref]


Gastrointestinal side effects have included abdominal pain, diarrhea and vomiting.[Ref]


Musculoskeletal side effects have included contusion, joint injury, limb injury, road traffic accident, and arthralgia.[Ref]


Respiratory side effects have included upper respiratory tract infection and epistaxis.[Ref]

Nervous system

Nervous system side effects have included headache and head injury.[Ref]


Immunologic side effects have included allergic/anaphylactic reaction (including cutaneous reactions, alteration in blood pressure, nausea, dyspnea, fever, and chills).[Ref]


1. "Product Information. Corifact (factor XIII)." CSL Behring, King of Prussia, PA.

Not all side effects for factor XIII may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.