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Factor Xiii Dosage

Medically reviewed by Drugs.com. Last updated on Feb 4, 2020.

Applies to the following strengths: recombinant A-subunit

Usual Adult Dose for:

Usual Pediatric Dose for:

Additional dosage information:

Usual Adult Dose for Factor XIII Deficiency

CORTIFACT(R):
Initial dose: 40 international units/kg intravenously
Maximum rate: 4 mL/min
-Adjust dose up or down 5 international units/kg to maintain 5 to 20% trough factor XIII levels.

Routine prophylaxis: administer every 28 days

Perioperative management of surgical bleeding:
-Individualize dose based on factor XIII activity level, type of surgery, and clinical response.
-Monitor factor XIII levels during and after surgery.
-Examples of dose adjustment for peri-operative management, based on patient's last prophylactic dose:
--Last dose within 7 days: additional dose may not be needed
--Last dose 8 to 21 days ago: additional full or partial dose may be needed based on factor XIII activity level
--Last dose 21 to 28 days ago: full prophylactic dose.


TRETTEN(R):
Routine prophylaxis:
Initial dose: 35 international units/kg intravenously
Maximum rate: 1 to 2 mL/min
-Consider dose adjustment if adequate coverage is not achieved at the initial dose.
-Not for use in congenital factor XIII B-subunit deficiency.

Usual Pediatric Dose for Factor XIII Deficiency

CORTIFACT(R):
Initial dose: 40 international units/kg intravenously
Maximum rate: 4 mL/min
-Adjust dose up or down 5 international units/kg to maintain 5 to 20% trough factor XIII levels.

Routine prophylaxis: administer every 28 days

Perioperative management of surgical bleeding:
-Individualize dose based on factor XIII activity level, type of surgery, and clinical response.
-Monitor factor XIII levels during and after surgery.
-Examples of dose adjustment for peri-operative management, based on patient's last prophylactic dose:
--Last dose within 7 days: additional dose may not be needed
--Last dose 8 to 21 days ago: additional full or partial dose may be needed based on factor XIII activity level
--Last dose 21 to 28 days ago: full prophylactic dose.


TRETTEN(R):
Routine prophylaxis:
Initial dose: 35 international units/kg intravenously
Maximum rate: 1 to 2 mL/min
-Consider dose adjustment if adequate coverage is not achieved at the initial dose.
-Not for use in congenital factor XIII B-subunit deficiency.

Renal Dose Adjustments

Data not available

Liver Dose Adjustments

Data not available

Dose Adjustments

CORTIFACT(R):
Dose adjustment using Berichrom Activity Assay:
One trough level under 5%: increase by 5 international units/kg
Trough level 5 to 20%: no change
Two trough levels over 20%: decrease by 5 international units/kg
One trough level over 25%: decrease by 5 international units/kg

Precautions

CONTRAINDICATIONS:
-Anaphylactic or severe systemic reactions to human plasma-derived products
-Hypersensitivity to any of the ingredients

Consult WARNINGS section for additional precautions.

Dialysis

Data not available

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.