Eraxis Side Effects

Generic name: anidulafungin

Medically reviewed by Drugs.com. Last updated on Feb 22, 2024.

Note: This document provides detailed information about Eraxis Side Effects associated with anidulafungin. Some dosage forms listed on this page may not apply specifically to the brand name Eraxis.

Applies to anidulafungin: intravenous powder for solution.

Serious side effects of Eraxis

Along with its needed effects, anidulafungin (the active ingredient contained in Eraxis) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur while taking anidulafungin:

Less common

• black, tarry stools
• chills
• cough
• decreased urine
• dry mouth
• fever
• increased thirst
• irregular heartbeat
• loss of appetite
• lower back or side pain
• mood or mental changes
• muscle pain or cramps
• nausea
• numbness or tingling in the hands, feet or lips
• painful or difficult urination
• pale skin
• seizures
• sore throat
• sores, ulcers, or white spots on the lips or in the mouth
• trouble breathing
• unusual bleeding or bruising
• unusual tiredness or weakness
• vomiting

Rare

• back pain
• bleeding gums
• blood in the urine or stools
• bloody stools
• bluish color of skin
• blurred or loss of vision
• changes in skin color
• chest pain or tightness
• clay-colored stools
• constipation
• dark urine
• depression
• diarrhea
• dizziness
• dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
• drowsiness
• extra heartbeats
• fainting
• fast heartbeat
• flushed, dry skin
• flushing
• fruit-like breath odor
• headache
• hives or welts
• incoherent speech
• increased hunger
• increased urination
• irregular fast heartbeat
• irritability
• itching
• large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
• light-colored stools
• metallic taste
• muscle spasms (tetany) or twitching
• muscle weakness
• nervousness
• pain, redness, or swelling in the arm or leg
• pain, tenderness, and swelling of foot or leg
• pinpoint red spots on the skin
• pounding in the ears
• redness of the skin
• restlessness
• skin rash
• slow heartbeat
• sore mouth or tongue
• stomach pain
• sweating
• swelling of the feet or lower legs
• swollen glands
• trembling
• unexplained weight loss
• unpleasant breath odor
• unusually warm skin
• vomiting of blood
• weakness
• weight loss
• white patches in the mouth or throat or on the tongue
• white patches with diaper rash
• yellow eyes or skin

Other side effects of Eraxis

Some side effects of anidulafungin may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Rare

• acid or sour stomach
• belching
• bloating or swelling of the face, arms, hands, lower legs, or feet
• disturbed color perception
• double vision
• eye pain
• feeling of warmth
• feeling unusually cold
• halos around light
• indigestion
• loss of bowel control
• night blindness
• over bright appearance of lights
• rapid weight gain
• redness of the face, neck, arms, and occasionally, upper chest
• shivering
• stomach discomfort or upset
• tingling of the hands or feet
• tunnel vision
• unusual weight gain or loss

For healthcare professionals

Applies to anidulafungin: intravenous powder for injection.

General

The most common side effects reported during studies in patients with candidemia and other Candida infections were hypokalemia, nausea, diarrhea, vomiting, pyrexia, and insomnia. This drug was discontinued in 11.5% of patients due to side effects; the most common side effects leading to discontinuation were multi-organ failure and systemic Candida infection.

The most common side effects reported during a study in patients with esophageal candidiasis were diarrhea, pyrexia, anemia, headache, vomiting, nausea, and dyspepsia. This drug was discontinued in 9% of patients due to side effects; the most common side effect leading to discontinuation was maculopapular rash.^[Ref]

Metabolic

• Very common (10% or more): Hypokalemia (up to 25%), hypomagnesemia (up to 12%)
• Common (1% to 10%): Hypoglycemia, hyperglycemia, hyperkalemia, dehydration
• Uncommon (0.1% to 1%): Hyperuricemia, hypocalcemia, hyponatremia, hypoalbuminemia, hypophosphatemia
• Frequency not reported: Hypercalcemia, hypernatremia, hypoproteinemia^[Ref]

Gastrointestinal

• Very common (10% or more): Nausea (up to 24%), diarrhea (up to 18%), vomiting (up to 18%)
• Common (1% to 10%): Constipation, dyspepsia, abdominal pain, oral candidiasis
• Uncommon (0.1% to 1%): Upper abdominal pain, dry mouth, esophageal ulcer
• Frequency not reported: Increased amylase, increased lipase, fecal incontinence, gastroesophageal reflux disease, abdominal distension, stomatitis, gastroenteritis^[Ref]

Other

• Very common (10% or more): Pyrexia (up to 18%), bacteremia (up to 18%), increased blood alkaline phosphatase (up to 12%), peripheral edema (up to 11%)
• Common (1% to 10%): Sepsis, chest pain, flushing
• Uncommon (0.1% to 1%): Hot flushes, chills, increased blood LDH
• Frequency not reported: Infusion-related reaction, rigors, clostridial infection, fungemia, candidiasis, multi-organ failure, systemic Candida infection, infusion-related side effects (possibly histamine-mediated; included rash, urticaria, flushing, pruritus, bronchospasm, dyspnea, hypotension), decreased potassium, decreased magnesium, device-related infection^[Ref]

Cardiovascular

• Very common (10% or more): Hypotension (up to 15%), hypertension (up to 12%), deep vein thrombosis (up to 10%)
• Common (1% to 10%): ECG QT prolonged
• Uncommon (0.1% to 1%): Phlebitis, superficial thrombophlebitis
• Frequency not reported: ECG early transition, atrial fibrillation, bundle branch block (right), sinus arrhythmia, ventricular extrasystoles^[Ref]

Psychiatric

• Very common (10% or more): Insomnia (up to 15%)
• Common (1% to 10%): Confusional state, depression
• Uncommon (0.1% to 1%): Anxiety, delirium, auditory hallucination
• Frequency not reported: Agitation^[Ref]

Genitourinary

• Very common (10% or more): Urinary tract infection (up to 15%)
• Uncommon (0.1% to 1%): Hematuria^[Ref]

Respiratory

• Very common (10% or more): Dyspnea (up to 12%), pleural effusion (up to 10%)
• Common (1% to 10%): Cough, pneumonia, respiratory distress
• Frequency not reported: Epistaxis, lower respiratory tract infection, upper respiratory tract infection, hemoptysis
• Postmarketing reports: Bronchospasm^[Ref]

Hematologic

• Common (1% to 10%): Anemia, increased WBC, thrombocythemia, leukocytosis, coagulopathy, thrombocytopenia, decreased platelet count
• Uncommon (0.1% to 1%): Neutropenia, leukopenia, lymphangitis, decreased lymphocyte count
• Frequency not reported: Prothrombin time prolonged, increased platelet count, pancytopenia, thrombocytosis, febrile neutropenia^[Ref]

Nervous system

• Common (1% to 10%): Headache, convulsion
• Uncommon (0.1% to 1%): Dizziness, paresthesia, central pontine myelinolysis, dysgeusia, Guillain-Barre syndrome, tremor, unilateral deafness
• Frequency not reported: Seizure^[Ref]

Hepatic

• Common (1% to 10%): Increased hepatic enzymes, increased ALT, increased AST, increased blood bilirubin, cholestasis, increased GGT
• Uncommon (0.1% to 1%): Hepatic necrosis
• Frequency not reported: Significant hepatic dysfunction, abnormal liver function tests, hepatitis, hepatic failure, increased transaminases^[Ref]

Hypersensitivity

• Postmarketing reports: Anaphylactic shock, anaphylactic reaction^[Ref]

Dermatologic

• Common (1% to 10%): Decubitus ulcer, rash, pruritus
• Uncommon (0.1% to 1%): Urticaria, angioneurotic edema, hyperhidrosis
• Frequency not reported: Maculopapular rash, erythema, increased sweating, generalized rash^[Ref]

Renal

• Common (1% to 10%): Increased blood creatinine
• Uncommon (0.1% to 1%): Renal failure
• Frequency not reported: Increased urea^[Ref]

Musculoskeletal

• Common (1% to 10%): Back pain
• Uncommon (0.1% to 1%): Myalgia, monoarthritis, increased blood creatine phosphokinase
• Frequency not reported: Pain in extremity^[Ref]

Local

• Uncommon (0.1% to 1%): Infusion site pain, injection site reaction^[Ref]

Ocular

• Uncommon (0.1% to 1%): Altered visual depth perception
• Frequency not reported: Eye pain, blurred vision, visual disturbance, periorbital edema^[Ref]

Further information

Eraxis side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.

Medical Disclaimer