EpiPen JR 2-Pak Side Effects
Generic Name: epinephrine
Note: This document contains side effect information about epinephrine. Some of the dosage forms listed on this page may not apply to the brand name EpiPen JR 2-Pak.
For the Consumer
Applies to epinephrine: injection injectable, injection solution
Along with its needed effects, epinephrine (the active ingredient contained in EpiPen JR 2-Pak) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur while taking epinephrine:
Incidence not known- Abnormal or decreased touch sensation
- anxiety
- arm, back, or jaw pain
- bleeding, blistering, burning, coldness, discoloration of the skin, feeling of pressure, hives, infection, inflammation, itching, lumps, numbness, pain, rash, redness, scarring, soreness, stinging, swelling, tenderness, tingling, ulceration, or warmth at the injection site
- blurred vision
- chest pain or discomfort
- chest tightness or heaviness
- cold, pale, or bluish color of the skin of the fingers or toes
- dizziness
- fainting
- fast, slow, irregular, pounding, or racing heartbeat or pulse
- fear or nervousness
- headache
- nausea
- numbness, tingling, or pain in the fingers
- paleness of the skin
- pounding in the ears
- restlessness
- shakiness in the legs, arms, hands, or feet
- stroke
- sweating
- trembling or shaking of the hands or feet
- troubled breathing
- unusual tiredness or weakness
- vomiting
Get emergency help immediately if any of the following symptoms of overdose occur while taking epinephrine:
Symptoms of overdose- Agitation
- coldness of the skin
- confusion
- decreased awareness or responsiveness
- decreased urine output
- depression
- drowsiness
- hostility
- irritability
- lightheadedness
- loss of consciousness
- muscle twitching
- rapid weight gain
- rapid, deep breathing
- seizures
- severe sleepiness
- stomach cramps
- swelling of the face, ankles, or hands
- unusual drowsiness, dullness, or feeling of sluggishness
For Healthcare Professionals
Applies to epinephrine: compounding powder, inhalation aerosol, inhalation solution, injectable kit, injectable solution, intravenous solution, subcutaneous suspension
General
Due to the lack of randomized, controlled clinical trials for the treatment of anaphylaxis, the true incidence of adverse reactions associated with the systemic use of this drug is difficult to determine. The most commonly reported adverse reactions include anxiety, apprehensiveness, restlessness, tremor, weakness, dizziness, sweating, palpitations, pallor, nausea and vomiting, headache, and/or respiratory difficulties.[Ref]
Cardiovascular
Frequency not reported: Tachycardia, supraventricular tachycardia, ventricular arrhythmias, myocardial ischemia, myocardial infarction, limb/peripheral ischemia, palpitations, angina, arrhythmias, hypertension, vasoconstriction, ventricular ectopy, ventricular fibrillation, cold extremities, electrocardiogram changes, stress cardiomyopathy[Ref]
Nervous system
Frequency not reported: Headache, paresthesia, tremor, stroke, central nervous system bleeding, dizziness, cerebral hemorrhage, memory impaired, lightheadedness, psychomotor agitation, tingling, Parkinsonism aggravated, syncope, convulsions, subarachnoid hemorrhage, hemiplegia[Ref]
Psychiatric
Frequency not reported: Nervousness, excitability, anxiety, apprehension, restlessness, disorientation, panic, hallucinations, psychosis, fear, sleeplessness/insomnia, tenseness, confusion, irritability[Ref]
Local
Frequency not reported: Extravasation, injection site pallor, coldness at injection site, hypoesthesia at injection site, injury at injection site, local ischemic necrosis[Ref]
Dermatologic
Frequency not reported: Diaphoresis, pallor, piloerection, skin blanching, skin necrosis with extravasation, necrotizing fasciitis, flushing/redness of skin and face, hyperhidrosis[Ref]
Metabolic
Frequency not reported: Hypoglycemia, hyperglycemia, insulin resistance, hypokalemia, lactic acidosis, insulin secretion inhibited, metabolic acidosis, anorexia[Ref]
Respiratory
Frequency not reported: Pulmonary edema, rales, respiratory difficulty, dyspnea, bronchospasm, hypoxia of mucosa[Ref]
Renal
Frequency not reported: Renal insufficiency[Ref]
Hypersensitivity
Hypersensitivity side effects have been extremely unusual. Contact dermatitis has been associated with ocularly applied epinephrine (the active ingredient contained in EpiPen JR 2-Pak) These reactions have typically presented with lid edema and a thick yellow discharge.
Gastrointestinal
Frequency not reported: Nausea, vomiting, bowel necrosis, hypersalivation[Ref]
Genitourinary
Frequency not reported: Urinary retention, difficult micturition[Ref]
Hematologic
Frequency not reported: Thrombocytosis[Ref]
Musculoskeletal
Frequency not reported: Myonecrosis[Ref]
Other
Frequency not reported: Chest pain, weakness, gas gangrene, asthenia[Ref]
Ocular
Frequency not reported: Corneal endothelial damage[Ref]
Endocrine
Frequency not reported: Growth hormone secretion stimulated[Ref]
References
1. "Product Information. Epinephrine (EPINEPHrine)." Physicians Total Care, Tulsa, OK.
2. "Product Information. Auvi-Q (EPINEPHrine)." sanofi-aventis, Bridgewater, NJ.
3. "Product Information. EpiPen (EPINEPHrine)." Dey Laboratories, Napa, CA.
4. Cerner Multum, Inc. "Australian Product Information." O 0
5. "Product Information. Adrenalin (EPINEPHrine)." A-S Medication Solutions, Chicago, IL.
6. "Product Information. Adrenaclick Two-Pack (EPINEPHrine)." Amedra Pharmaceuticals LLC, Middlesex, NJ.
7. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Some side effects may not be reported. You may report them to the FDA.
More about EpiPen JR 2-Pak (epinephrine)
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- Drug class: adrenergic bronchodilators
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