EpiPen Auto-Injector Side Effects
Generic name: epinephrine
Medically reviewed by Drugs.com. Last updated on Sep 6, 2022.
Note: This document contains side effect information about epinephrine. Some dosage forms listed on this page may not apply to the brand name EpiPen Auto-Injector.
Applies to epinephrine: inhalation aerosol liquid. Other dosage forms:
Serious side effects
Along with its needed effects, epinephrine (the active ingredient contained in EpiPen Auto-Injector) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur while taking epinephrine:
Incidence not known
- Blurred vision
- chest pain or discomfort
- difficulty in speaking
- double vision
- inability to move the arms, legs, or facial muscles
- inability to speak
- pain or discomfort in the arms, jaw, back, or neck
- pounding in the ears
- slow or fast heartbeat
- slow speech
Other side effects
Some side effects of epinephrine may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.
Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
Incidence not known
For Healthcare Professionals
Applies to epinephrine: compounding powder, inhalation aerosol, inhalation solution, injectable kit, injectable solution, intravenous solution, subcutaneous suspension.
Due to the lack of randomized, controlled clinical trials for the treatment of anaphylaxis, the true incidence of adverse reactions associated with the systemic use of this drug is difficult to determine. The most commonly reported adverse reactions include anxiety, apprehensiveness, restlessness, tremor, weakness, dizziness, sweating, palpitations, pallor, nausea and vomiting, headache, and/or respiratory difficulties.[Ref]
Frequency not reported: Tachycardia, supraventricular tachycardia, ventricular arrhythmias, myocardial ischemia, myocardial infarction, limb/peripheral ischemia, palpitations, angina, arrhythmias, hypertension, vasoconstriction, ventricular ectopy, ventricular fibrillation, cold extremities, electrocardiogram changes, stress cardiomyopathy[Ref]
Frequency not reported: Headache, paresthesia, tremor, stroke, central nervous system bleeding, dizziness, cerebral hemorrhage, memory impaired, lightheadedness, psychomotor agitation, tingling, Parkinsonism aggravated, syncope, convulsions, subarachnoid hemorrhage, hemiplegia[Ref]
Frequency not reported: Nervousness, excitability, anxiety, apprehension, restlessness, disorientation, panic, hallucinations, psychosis, fear, sleeplessness/insomnia, tenseness, confusion, irritability[Ref]
Frequency not reported: Extravasation, injection site pallor, coldness at injection site, hypoesthesia at injection site, injury at injection site, local ischemic necrosis[Ref]
Frequency not reported: Renal insufficiency[Ref]
Hypersensitivity side effects have been extremely unusual. Contact dermatitis has been associated with ocularly applied epinephrine (the active ingredient contained in EpiPen Auto-Injector) These reactions have typically presented with lid edema and a thick yellow discharge.
Frequency not reported: Nausea, vomiting, bowel necrosis, hypersalivation[Ref]
Frequency not reported: Myonecrosis[Ref]
Frequency not reported: Chest pain, weakness, gas gangrene, asthenia[Ref]
Frequency not reported: Corneal endothelial damage[Ref]
Frequency not reported: Growth hormone secretion stimulated[Ref]
Frequently asked questions
More about EpiPen Auto-Injector (epinephrine)
- Check interactions
- Latest FDA alerts (4)
- Dosage information
- During pregnancy
- Drug class: adrenergic bronchodilators
Related treatment guides
1. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
2. Cerner Multum, Inc. "Australian Product Information." O 0
3. "Product Information. Adrenaclick Two-Pack (epinephrine)." Amedra Pharmaceuticals LLC (2016):
4. "Product Information. Auvi-Q (epinephrine)." sanofi-aventis (2016):
5. "Product Information. EpiPen (epinephrine)." Dey Laboratories (2016):
6. "Product Information. Adrenalin (epinephrine)." A-S Medication Solutions (2016):
7. "Product Information. Epinephrine (epinephrine)." Physicians Total Care (2016):
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Some side effects may not be reported. You may report them to the FDA.