Drotrecogin Alfa Side Effects
Applies to drotrecogin alfa: intravenous powder for solution.
Precautions
Drotrecogin alfa can cause bleeding that usually is not serious. However, serious bleeding may occur in some people. To help prevent serious bleeding, carefully follow any instructions given by your doctor. Move around as little as possible, and do not get out of bed on your own, unless your doctor tells you it is okay.
Serious side effects of drotrecogin alfa
Along with its needed effects, drotrecogin alfa may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor or nurse immediately if any of the following side effects occur while taking drotrecogin alfa:
More common side effects
- bleeding
For healthcare professionals
Applies to drotrecogin alfa: intravenous powder for injection.
General adverse events
The most common side effect associated with drotrecogin alfa has been bleeding.[Ref]
Hematologic
Hematologic side effects have most commonly included bleeding (25% vs 18% with placebo). The majority of events were ecchymoses or gastrointestinal tract bleeding. Serious bleeding has been reported in 3.5% of patients (vs 2% with placebo) and included intracranial hemorrhage, life threatening hemorrhage, and any event requiring 3 or more units of packed red blood cells per days for 2 consecutive days.[Ref]
Serious bleeding events have been reported at the following sites: Gastrointestinal, intra-abdominal, intrathoracic, retroperitoneal, intracranial, genitourinary, skin or soft tissues.[Ref]
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References
1. (2001) "Product Information. Xigris (drotrecogin alfa)." Lilly, Eli and Company
2. Bernard GR, Vincent JL, Laterre PF, et al. (2001) "Efficacy and safety of recombinant human activated protein C for severe sepsis." N Engl J Med, 344, p. 699-709
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Further information
Drotrecogin alfa side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following this guide.