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Dibucaine topical Side Effects

For the Consumer

Applies to dibucaine topical: topical application cream, topical application ointment

In addition to its needed effects, some unwanted effects may be caused by dibucaine topical. In the event that any of these side effects do occur, they may require medical attention.

Major Side Effects

You should check with your doctor immediately if any of these side effects occur when taking dibucaine topical:

Incidence not known:
  • Chest pain
  • fast or irregular heartbeat
  • tightness in the chest
  • unusual warmth or flushing of skin

Minor Side Effects

Some of the side effects that can occur with dibucaine topical may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:

Incidence not known:
  • Diarrhea
  • eye irritation
  • nausea
  • skin irritation
  • vomiting

For Healthcare Professionals

Applies to dibucaine topical: compounding powder, topical cream, topical ointment


General side effects have included methemoglobinemia, irregular heartbeats, seizures, coma, respiratory depression, and death. Children may be at an increased risk for adverse effects, as well as those who apply large amounts of anesthetics (or cover large areas of skin), leave these products on for prolonged periods, or cover with occlusive dressings after application.[Ref]


1. "Product Information. Nupercainal (dibucaine topical)." Ciba-Geigy Pharmaceuticals, East Hanover, NJ.

2. "Multum Information Services, Inc. Expert Review Panel"

Not all side effects for dibucaine topical may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.