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Dibucaine topical Side Effects

Medically reviewed by Last updated on Aug 31, 2023.

Applies to dibucaine topical: topical application ointment.

Serious side effects of Dibucaine topical

Along with its needed effects, dibucaine topical may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking dibucaine topical:

Incidence not known

Other side effects of Dibucaine topical

Some side effects of dibucaine topical may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Incidence not known

For Healthcare Professionals

Applies to dibucaine topical: compounding powder, topical cream, topical ointment.


General side effects have included methemoglobinemia, irregular heartbeats, seizures, coma, respiratory depression, and death. Children may be at an increased risk for adverse effects, as well as those who apply large amounts of anesthetics (or cover large areas of skin), leave these products on for prolonged periods, or cover with occlusive dressings after application.[Ref]


1. Multum Information Services, Inc. Expert Review Panel

2. Product Information. Nupercainal (dibucaine topical). Ciba-Geigy Pharmaceuticals. 2001;PROD.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.