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Dexchlorpheniramine / phenylephrine Side Effects

For the Consumer

Applies to dexchlorpheniramine / phenylephrine: oral tablet extended release 12 hour

What are some side effects that I need to call my doctor about right away?

WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect:

  • Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing, swallowing, or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.

What are some other side effects of this drug?

All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away:

  • Dizziness.
  • Feeling nervous and excitable.
  • Not able to sleep.
  • Feeling sleepy.

These are not all of the side effects that may occur. If you have questions about side effects, call your doctor. Call your doctor for medical advice about side effects.

You may report side effects to the FDA at 1-800-FDA-1088. You may also report side effects at

For Healthcare Professionals

Applies to dexchlorpheniramine/phenylephrine: oral tablet, oral tablet extended release


Gastrointestinal side effects have included nausea, dry mouth, anorexia, and heartburn.[Ref]

Nervous system

Nervous system side effects have included headache, dizziness, mild sedation, tremor, weakness, insomnia, drowsiness, restlessness, convulsions, central nervous system depression, and nervousness.[Ref]


Genitourinary side effects have included dysuria.[Ref]


Psychiatric side effects have included fear, anxiety, and tenseness.[Ref]


Cardiovascular side effects have included pallor, tachycardia, palpitations, arrhythmias, and cardiovascular collapse with hypotension.[Ref]


Respiratory side effects have included respiratory difficulty.[Ref]


Dermatologic side effects have included very rare reports of dermatitis.[Ref]


Ocular side effects have included blurring of vision.[Ref]


1. "Product Information. RhinaHist (dexchlorpheniramine-phenylephrine)." ProEthic Laboratories LLC, Montgomery, AL.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.

More about dexchlorpheniramine/phenylephrine

Consumer resources

Other brands: NalDex, RhinaHist

Professional resources

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