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Dacogen Side Effects

Generic name: decitabine

Medically reviewed by Last updated on Mar 18, 2024.

Note: This document contains side effect information about decitabine. Some dosage forms listed on this page may not apply to the brand name Dacogen.

Applies to decitabine: intravenous powder for solution.

Serious side effects of Dacogen

Along with its needed effects, decitabine (the active ingredient contained in Dacogen) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur while taking decitabine:

More common

Less common

Incidence not known

Other side effects of Dacogen

Some side effects of decitabine may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

Less common

For Healthcare Professionals

Applies to decitabine: intravenous powder for injection.


Very common (10% or more): Neutropenia (90%), thrombocytopenia (89%), anemia (68%), febrile neutropenia (29%), leukopenia (28%), lymphadenopathy (12%)

Common (1% to 10%): Thrombocythemia

Uncommon (0.1% to 1%): Pancytopenia[Ref]


Very common (10% or more): Nausea (42%), constipation (35%), diarrhea (34%), vomiting (25%), abdominal pain (14%), oral mucosal petechiae (13%), stomatitis (12%), dyspepsia (12%), ascites (10%)

Common (1% to 10%): Gingival bleeding, hemorrhoids, loose stools, tongue ulceration, dysphagia, oral soft tissue disorder, lip ulceration, abdominal distension, upper abdominal pain, gastroesophageal reflux disease, glossodynia

Frequency not reported: Enterocolitis (including neutropenic colitis, cecitis)[Ref]


Very common (10% or more): Cough (40%), pneumonia (24%), pharyngitis (16%), epistaxis (14%), lung crackles (14%), breath sounds decreased (10%), hypoxia (10%)

Common (1% to 10%): Sinusitis, rales, postnasal drip

Frequency not reported: Interstitial lung disease[Ref]


Very common (10% or more): Pyrexia (53%), peripheral edema (25%), rigors (22%), edema (18%), pain (13%), lethargy (12%), tenderness (11%), blood alkaline phosphatase increased (11%), blood urea increased (10%)

Common (1% to 10%): Fall, chest wall pain, intermittent pyrexia, malaise, crepitations, blood lactate dehydrogenase increased, blood albumin decreased, blood bicarbonate increased, blood chloride decreased, decreased total protein, blood bilirubin decreased[Ref]


Very common (10% or more): Hyperglycemia (33%), hypoalbuminemia (24%), hypomagnesemia (24%), hypokalemia (22%), hyponatremia (19%), appetite decreased (16%), anorexia (16%), hyperkalemia (13%)

Common (1% to 10%): Dehydration[Ref]

Nervous system

Very common (10% or more): Headache (28%), dizziness (18%), hypoesthesia (11%)[Ref]


Very common (10% or more): Insomnia (28%), confusion (12%), anxiety (11%)[Ref]


Very common (10% or more): Bacterial, viral, fungal infections (63%), candida infection (10%)

Common (1% to 10%): Septic shock, sepsis, staphylococcal infection, oral candidiasis, bacteremia[Ref]


Very common (10% or more): Ecchymosis (22%), rash (19%), erythema (14%), cellulitis (12%) skin lesion (11%), pruritus (11%)

Common (1% to 10%): Alopecia, urticaria, swelling face

Uncommon (0.1% to 1%): Acute febrile neutrophilic dermatosis (Sweet's syndrome)[Ref]


Very common (10% or more): Arthralgia (20%), pain in limb (19%), back pain (17%)

Common (1% to 10%): Chest wall pain, musculoskeletal discomfort, myalgia[Ref]


Very common (10% or more): Petechiae (39%), pallor (23%), cardiac murmur (16%)

Common (1% to 10%): Pulmonary edema, hypotension, hematoma[Ref]


Very common (10% or more): Hyperbilirubinemia (14%)[Ref]


Common (1% to 10%): Hypersensitivity including anaphylaxis[Ref]


Common (1% to 10%): Blurred vision[Ref]


Very common (10% or more): Urinary tract infection (15%)

Common (1% to 10%): Dysuria, urinary frequency



Common (1% to 10%): Injection site erythema, injection site pain, injection site swelling[Ref]


1. Cerner Multum, Inc. "UK Summary of Product Characteristics."

2. (2017) "Product Information. Decitabine (decitabine)." Accord Healthcare Inc

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.