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CytoGam Side Effects

Generic Name: cytomegalovirus immune globulin

Note: This document contains side effect information about cytomegalovirus immune globulin. Some of the dosage forms listed on this page may not apply to the brand name CytoGam.

For the Consumer

Applies to cytomegalovirus immune globulin: parenteral injection for iv infusion

Side effects include:

Flushing, chills, muscle cramps, back pain, fever, nausea, vomiting, arthralgia, wheezing/shortness of breath/chest tightness.

For Healthcare Professionals

Applies to cytomegalovirus immune globulin: intravenous solution

General

The most frequent side effects have included minor reactions such as flushing, chills, muscle cramps, back pain, fever, nausea, vomiting, arthralgia, and wheezing in < 6.0% of all infusions. These reactions were most often related to the infusion rate. A decrease in blood pressure was observed in 1 of 1039 infusions in clinical trials. If a minor reaction occurs, the infusion should be slowed or temporarily interrupted.[Ref]

Renal

Renal side effects have included increases in serum creatinine and blood urea nitrogen (BUN) within 1 to 2 days after IGIV infusion, oliguria or anuria requiring dialysis, acute renal failure, acute tubular necrosis, proximal tubular nephropathy, and osmotic nephrosis.[Ref]

Cardiovascular

Cardiovascular side effects have included cardiac arrest, thromboembolism, vascular collapse, and hypotension.[Ref]

Dermatologic

Dermatologic side effects have included Stevens-Johnson syndrome, epidermolysis, erythema multiforme, and bullous dermatitis.[Ref]

Gastrointestinal

Gastrointestinal side effects have included abdominal pain.[Ref]

Hematologic

Hematologic side effects have included pancytopenia, leukopenia, hemolysis, and positive direct antiglobulin (Coombs) test.[Ref]

Hepatic

Hepatic side effects have included hepatic dysfunction.[Ref]

Hypersensitivity

Hypersensitivity reactions including angioneurotic edema and anaphylactic shock may occur. Clinical anaphylaxis may occur even when the patient is not known to be sensitized to immune globulin products. A reaction may be related to the rate of infusion.[Ref]

Musculoskeletal

Musculoskeletal side effects have included back pain.[Ref]

Nervous system

Nervous system side effects have included coma, loss of consciousness, seizures, and tremor.[Ref]

Respiratory

Respiratory side effects have included apnea, acute respiratory distress syndrome (ARDS), transfusion associated lung injury (TRALI), cyanosis, hypoxemia, pulmonary edema, dyspnea, and bronchospasm.[Ref]

Other

Other side effects have included pyrexia and rigors.[Ref]

References

1. "Product Information. Cytogam (cytomegalovirus immune globulin)." Medimmune Inc, Gaithersburg, MD.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.

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