CytoGam Side Effects
Generic Name: cytomegalovirus immune globulin
Note: This document contains side effect information about cytomegalovirus immune globulin. Some of the dosage forms listed on this page may not apply to the brand name CytoGam.
For the Consumer
Applies to cytomegalovirus immune globulin: parenteral injection for iv infusion
Side effects include:
Flushing, chills, muscle cramps, back pain, fever, nausea, vomiting, arthralgia, wheezing/shortness of breath/chest tightness.
For Healthcare Professionals
Applies to cytomegalovirus immune globulin: intravenous solution
The most frequent side effects have included minor reactions such as flushing, chills, muscle cramps, back pain, fever, nausea, vomiting, arthralgia, and wheezing in < 6.0% of all infusions. These reactions were most often related to the infusion rate. A decrease in blood pressure was observed in 1 of 1039 infusions in clinical trials. If a minor reaction occurs, the infusion should be slowed or temporarily interrupted.[Ref]
Renal side effects have included increases in serum creatinine and blood urea nitrogen (BUN) within 1 to 2 days after IGIV infusion, oliguria or anuria requiring dialysis, acute renal failure, acute tubular necrosis, proximal tubular nephropathy, and osmotic nephrosis.[Ref]
Cardiovascular side effects have included cardiac arrest, thromboembolism, vascular collapse, and hypotension.[Ref]
Dermatologic side effects have included Stevens-Johnson syndrome, epidermolysis, erythema multiforme, and bullous dermatitis.[Ref]
Gastrointestinal side effects have included abdominal pain.[Ref]
Hematologic side effects have included pancytopenia, leukopenia, hemolysis, and positive direct antiglobulin (Coombs) test.[Ref]
Hepatic side effects have included hepatic dysfunction.[Ref]
Hypersensitivity reactions including angioneurotic edema and anaphylactic shock may occur. Clinical anaphylaxis may occur even when the patient is not known to be sensitized to immune globulin products. A reaction may be related to the rate of infusion.[Ref]
Musculoskeletal side effects have included back pain.[Ref]
Nervous system side effects have included coma, loss of consciousness, seizures, and tremor.[Ref]
Respiratory side effects have included apnea, acute respiratory distress syndrome (ARDS), transfusion associated lung injury (TRALI), cyanosis, hypoxemia, pulmonary edema, dyspnea, and bronchospasm.[Ref]
Other side effects have included pyrexia and rigors.[Ref]
1. "Product Information. Cytogam (cytomegalovirus immune globulin)." Medimmune Inc, Gaithersburg, MD.
Some side effects of CytoGam may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.
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