Cytarabine liposomal / daunorubicin liposomal Side Effects

Medically reviewed by Drugs.com. Last updated on Apr 24, 2022.

For the Consumer

Applies to cytarabine liposomal/daunorubicin liposomal: intravenous powder for solution

Warning

Intravenous route (Powder for Solution)

Do not interchange with other DAUNOrubicin- and/or cytarabine-containing productsDAUNOrubicin and cytarabine, liposome has different dosage recommendations than DAUNOrubicin hydrochloride injection, cytarabine injection, DAUNOrubicin citrate liposome injection, and cytarabine liposome injection. Verify drug name and dose prior to preparation and administration to avoid dosing errors.

Side effects requiring immediate medical attention

Along with its needed effects, cytarabine liposomal / daunorubicin liposomal may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur while taking cytarabine liposomal / daunorubicin liposomal:

More common

Bleeding gums
blood in the urine or stools
blurred vision
body aches or pain
chest pain, discomfort, or tightness
chills
confusion as to time, place, or person
cough
coughing up blood
deafness
decreased frequency or amount of urine
diarrhea
difficulty in breathing or swallowing
dizziness
dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
ear congestion
facial swelling
fainting
fast, slow, or irregular heartbeat
fever
general feeling of discomfort or illness
headache
holding false beliefs that cannot be changed by fact
increased blood pressure
increased menstrual flow or vaginal bleeding
increased thirst
itching of the genitals or other skin areas
loss of appetite
loss of voice
lower back or side pain
nausea
nervousness
nosebleeds
painful or difficult urination
pale skin
paralysis
pinpoint red spots on the skin
pounding in the ears
prolonged bleeding from cuts
rapid, shallow breathing
red or black, tarry stools
red or dark brown urine
runny or stuffy nose
scaling
seeing, hearing, or feeling things that are not there
skin rash
sneezing
sore throat
stomach cramps or pain
sweating
swelling
swelling of the face, fingers, feet, or lower legs
tenderness
thickening of the bronchial secretions
trouble breathing
ulcers, sores, or white spots in the mouth
unusual bleeding or bruising
unusual excitement, nervousness, or restlessness
unusual tiredness or weakness
vomiting
watery or bloody diarrhea
weakness
weight gain

Side effects not requiring immediate medical attention

Some side effects of cytarabine liposomal / daunorubicin liposomal may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

Anxiety
belching
bleeding after having a bowel movement
bleeding, blistering, burning, coldness, discoloration of the skin, feeling of pressure, hives, infection, inflammation, itching, lumps, numbness, pain, rash, redness, scarring, soreness, stinging, swelling, tenderness, tingling, ulceration, or warmth at the injection site
bone and muscle pain
burning, dry, or itching of the eyes
changes in vision
constipation
cracked lips
decreased appetite
discharge, excessive tearing
heartburn
indigestion
redness, pain, or swelling of the eye, eyelid, or inner lining of the eyelid
small red or purple spots on the skin
stomach discomfort or upset
trouble sleeping
uncomfortable swelling around the anus

For Healthcare Professionals

Applies to cytarabine liposomal / daunorubicin liposomal: intravenous powder for injection

Hematologic

Very common (10% or more): Hemorrhage (anal hemorrhage, blood blister, blood urine present, breast hematoma, catheter site bruise, catheter site hemorrhage, CNS hemorrhage, cerebral hematoma, cerebral hemorrhage, coagulopathy, conjunctival hemorrhage, contusion, ecchymosis, enterocolitis hemorrhagic, epistaxis, GI hemorrhage, gingival bleeding, hematemesis, hematochezia, hematoma, hematuria, hemoptysis, intracranial hemorrhage, subcutaneous hemorrhage, urinary tract hemorrhage, hemorrhoidal hemorrhage, lip hematoma/hemorrhage, melena, mouth/mucosal hemorrhage, periorbital hematoma/hemorrhage, pharyngeal hematoma/hemorrhage, post procedural contusion/hematoma/hemorrhage, pulmonary hemorrhage, purpura, rectal hemorrhage, retinal hemorrhage, scleral hemorrhage, scrotal hematoma, skin ulcer hemorrhage, small intestinal hemorrhage, stomatitis hemorrhagic, subdural hematoma/hemorrhage, subgaleal hematoma, tongue hemorrhage, traumatic hematoma, urethral hemorrhage, vaginal hemorrhage, vessel puncture site hemorrhage, vitreous hemorrhage (70%), febrile neutropenia (68%), thrombocytopenia (28%), neutropenia (17%), petechiae (11%)

Hypersensitivity

Frequency not reported: Hypersensitivity (including anaphylaxis)^[Ref]

Immunologic

Very common (10% or more): Bacteremia (excluding sepsis) (24%), fungal infection (18%), sepsis (excluding fungal) (11%)^[Ref]

Local

Very common (10% or more): Catheter/device/injection site reaction (16%)

Frequency not reported: Tissue necrosis^[Ref]

Musculoskeletal

Very common (10% or more): Musculoskeletal pain (e.g., arthralgia, back pain, bone pain, coccydynia, limb discomfort, musculoskeletal chest pain, myalgia, neck pain, pain in extremity, jaw pain) (38%)^[Ref]

Ocular

Very common (10% or more): Visual impairment (e.g., photophobia, photopsia, photosensitivity reaction, retinal tear, scintillating scotoma, uveitis, vision blurred, visual acuity reduced, visual impairment, vitreous detachment, vitreous floaters) (11%)

Common (1% to 10%): Conjunctivitis, dry eye, eye edema, eye swelling, eye irritation, eye pain, ocular hyperemia, periorbital edema, scleral hyperemia^[Ref]

Metabolic

Very common (10% or more): Decreased appetite (29%), hyponatremia (14%)

Common (1% to 10%): Hypokalemia, hyperbilirubinemia

Frequency not reported: Copper overload^[Ref]

Psychiatric

Very common (10% or more): Sleep disorders (e.g., abnormal dreams, insomnia, nightmare, sleep apnea) (25%), delirium (16%), anxiety (14%)

Common (1% to 10%): Hallucinations^[Ref]

Genitourinary

Frequency not reported: Penile edema, scrotal edema^[Ref]

Respiratory

Very common (10% or more): Epistaxis (36%), cough (33%), dyspnea (acute respiratory distress syndrome, acute respiratory failure, bronchospasm, exertional dyspnea, respiratory distress/failure, wheezing) (32%), pneumonia [excluding fungal] (e.g., bacterial, klebsiella, pseudomonas aeruginosa, viral) (26%), upper respiratory tract infection [excluding fungal] (18%), pleural effusion (16%)

Common (1% to 10%): Pneumonitis^[Ref]

Other

Very common (10% or more): Fatigue/asthenia (32%), pyrexia (17%)

Common (1% to 10%): Deafness^[Ref]

Nervous system

Very common (10% or more): Chills (23%)^[Ref]

Renal

Very common (10% or more): Renal insufficiency (e.g., azotemia, oliguria, acute/chronic renal failure) (11%)

Cardiovascular

Very common (10% or more): Edema (51%), arrhythmia (e.g., supraventricular arrhythmia, atrial fibrillation, atrial flutter, atrial tachycardia, atrioventricular block first/second degree, bradycardia, bundle branch block right, extrasystole, heart rate increased, nodal arrhythmia, sinus arrhythmia/arrest, sinus bradycardia/tachycardia, supraventricular tachycardia, ventricular extrasystole, ventricular tachycardia) (30%), hypotension (20%), nonconduction cardiotoxicity (e.g., acute coronary syndrome, acute endocarditis, acute myocardial infarction, angina pectoris, aortic valve incompetence, cardiac arrest, cardiac failure, cardiac failure congestive, cardiac murmur, cardiogenic shock, cardiomegaly, cardiomyopathy, cytotoxic cardiomyopathy, diastolic dysfunction, dilatation atrial, Dilatation ventricular, Ejection fraction decreased, Endocarditis, Left ventricular dysfunction, mitral valve incompetence, myocardial infarction, pericardial effusion, pericarditis, restrictive cardiomyopathy, right ventricular hypertrophy) (20%), hypertension (18%), chest pain (17%), pleural effusion (16%)^[Ref]

Dermatologic

Very common (10% or more): Rash (e.g., dermatitis, dermatitis acneiform, dermatitis allergic, dermatitis contact, eczema, erythema nodosum, exfoliative rash, psoriasis, erythematous, follicular, generalized, macular, maculopapular, papular, pruritic, pustular, skin exfoliation) (54%), pruritus (15%)^[Ref]

Gastrointestinal

Very common (10% or more): Nausea (47%), diarrhea/colitis (e.g., cecitis, colitis, enterocolitis, ileitis, neutropenic colitis, enteritis) (45%), mucositis (e.g., anal erosion, anorectal discomfort, duodenitis, gastric ulcer, GI inflammation, gingival pain, gingival swelling, gingivitis, glossodynia, laryngeal inflammation, lip ulceration, mouth ulceration, mucosal inflammation, mucosal ulceration, odynophagia, mouth edema, esophageal ulcer, esophagitis, oral mucosa erosion, oral mucosal blistering, oral mucosal erythema, pharyngeal ulceration, proctalgia, proctitis, rectal ulcer, stomatitis, tongue ulceration, oropharyngeal pain) (44%), constipation (40%), abdominal pain (33%), vomiting (24%), hemorrhoids (11%)

Common (1% to 10%): Dyspepsia^[Ref]