Ctexli Side Effects
Generic name: chenodiol
Medically reviewed by Drugs.com. Last updated on Feb 14, 2025.
Note: This document provides detailed information about Ctexli Side Effects associated with chenodiol. Some dosage forms listed on this page may not apply specifically to the brand name Ctexli.
Applies to chenodiol: oral tablet.
Important warnings
This medicine can cause some serious health issues
Oral route (tablet)
Because of the potential hepatotoxicity of chenodiol, poor response rate in some subgroups of chenodiol treated patients, and an increased rate of a need for cholecystectomy in other chenodiol treated subgroups, chenodiol is not an appropriate treatment for many patients with gallstones.
Chenodiol should be reserved for carefully selected patients and treatment must be accompanied by systematic monitoring for liver function alterations.
Aspects of patient selection, response rates and risks versus benefits are given in the insert.
Precautions
It is very important that your doctor check your progress at regular visits. This is to make sure that the medicine is working properly and to decide if you should continue to take it. Blood tests and certain laboratory tests (e.g., ultrasounds, X-rays) are needed to check for unwanted effects.
Using this medicine while you are pregnant can harm your unborn baby. Use an effective form of birth control to keep from getting pregnant. If you think you have become pregnant while using the medicine, tell your doctor right away.
Stop using this medicine and check with your doctor right away if you have pain or tenderness in the upper stomach; pale stools; dark urine; loss of appetite; nausea; unusual tiredness or weakness; or yellow eyes or skin. These could be symptoms of a serious liver problem.
Mild diarrhea may occur during treatment with chenodiol (the active ingredient contained in Ctexli) Do not take any medicine to treat diarrhea without first checking with your doctor. If you have any questions or if mild diarrhea continues or gets worse, check with your doctor.
Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements.
Common side effects of Ctexli
Some side effects of chenodiol may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.
Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
More common side effects
- diarrhea
Less common side effects
- abdominal or stomach pain
- acid or sour stomach
- belching
- bloated
- cramps
- difficulty having a bowel movement (stool)
- excess air or gas in the stomach or intestines
- full feeling
- heartburn
- indigestion
- loss of appetite
- nausea and vomiting
- pain in the chest below the breastbone
- pain or discomfort in chest, upper stomach, or throat
- passing gas
- stomach discomfort or upset
- weight loss
Serious side effects of Ctexli
Along with its needed effects, chenodiol may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur while taking chenodiol:
Incidence not known
- black, tarry stools
- chest pain
- chills
- cough
- fever
- painful or difficult urination
- shortness of breath
- sore throat
- sores, ulcers, or white spots on the lips or in the mouth
- swollen glands
- unusual bleeding or bruising
- unusual tiredness or weakness
For healthcare professionals
Applies to chenodiol: oral tablet.
Gastrointestinal adverse events
- Frequency not reported: Constipation/mild intermittent constipation, cramps, diarrhea, dyspepsia, epigastric distress, flatulence, gastrostomy, heartburn, nausea, nonspecific abdominal pain, urgency, vomiting[Ref]
Hepatic
- Frequency not reported: ALT elevations, biliary colic, cholecystectomy, hepatic adverse reactions, intrahepatic cholestasis, lithiasis, lithocholate-like lesions in the canalicular membrane, serum transaminase elevations, toxic hepatitis[Ref]
Metabolic
- Frequency not reported: Anorexic, increased serum low density lipoprotein (LDL) cholesterol, increased serum total cholesterol, small decreases in serum triglyceride levels[Ref]
Serum total cholesterol and LDL cholesterol may increase by at least 10%.
Small decreases in serum triglycerides occurred in female patients.[Ref]
Musculoskeletal
- Frequency not reported: Humerus fracture, foot operation, rheumatoid arthritis[Ref]
Cardiovascular
- Frequency not reported: Angina pectoris[Ref]
Respiratory
- Frequency not reported: Pneumothorax[Ref]
Hematologic
- Frequency not reported: Decreases in while cell count[Ref]
Genitourinary
- Frequency not reported: Urinary incontinence[Ref]
Ocular
- Frequency not reported: Cataract operation[Ref]
Other
Psychiatric
- Frequency not reported: Depression[Ref]
See also:
Actigall
Actigall is used for gallbladder disease, primary biliary cholangitis
Botox
Botox is used for cosmetic purposes and to treat overactive bladder symptoms, urinary incontinence ...
Urso Forte
Urso Forte is used for gallbladder disease, primary biliary cholangitis
Ursodiol
Ursodiol information from Drugs.com, includes Ursodiol side effects, interactions and indications.
References
1. EMEA. European Medicines Agency (2007) EPARs. European Union Public Assessment Reports. http://www.ema.europa.eu/ema/index.jsp?curl=pages/includes/medicines/medicines_landingpage.jsp&mid
2. (2009) "Product Information. Chenodal (chenodeoxycholic acid)." Manchester Pharmaceutical
More about Ctexli (chenodiol)
- Check interactions
- Compare alternatives
- Imprints, shape & color data
- Dosage information
- During pregnancy
- FDA approval history
- Drug class: gallstone solubilizing agents
Patient resources
Other brands
Professional resources
Other brands
Related treatment guides
Further information
Ctexli side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following this guide.