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Asclera Side Effects

Generic Name: polidocanol

Note: This document contains side effect information about polidocanol. Some of the dosage forms listed on this page may not apply to the brand name Asclera.

In Summary

Common side effects of Asclera include: hematoma at injection site, hematoma, pain at injection site, and skin discoloration at injection site. Other side effects include: pain. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to polidocanol: intravenous foam, intravenous solution

Along with its needed effects, polidocanol (the active ingredient contained in Asclera) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur while taking polidocanol:

More common
  • Bleeding, blistering, burning, coldness, discoloration of the skin, feeling of pressure, hives, infection, inflammation, itching, lumps, numbness, pain, rash, redness, scarring, soreness, stinging, swelling, tenderness, tingling, ulceration, or warmth at the injection site
  • collection of blood under the skin of the injection site
  • deep, dark purple bruise at the injection site
Incidence not known
  • Anxiety
  • blue-green to black skin discoloration
  • blurred vision
  • burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
  • chest pain
  • cough
  • darkening of the skin
  • difficult or labored breathing
  • difficulty with swallowing
  • dizziness or lightheadedness
  • fainting
  • fast, irregular, pounding, or racing heartbeat or pulse
  • fever
  • inability to speak
  • increased hair growth in the treatment area
  • large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
  • loss of consciousness
  • nerve injury
  • no blood pressure or pulse
  • noisy breathing
  • pain, redness, or sloughing of the skin at the injection site
  • pain, redness, or swelling in the arm or leg
  • puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
  • seizures
  • severe or sudden headache
  • shortness of breath
  • skin rash
  • slurred speech
  • sores, welting, or blisters
  • stopping of the heart
  • sudden shortness of breath or troubled breathing
  • temporary blindness
  • tightness in the chest
  • unconsciousness
  • unusual tiredness or weakness
  • weakness in the arm or leg on one side of the body, sudden and severe
  • wheezing

Some side effects of polidocanol may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Incidence not known
  • Confusion
  • feeling of warmth
  • redness of the face, neck, arms, and occasionally, upper chest
  • sudden sweating

For Healthcare Professionals

Applies to polidocanol: injectable foam, injectable kit, injectable solution


Very common (10% or more): Injection site hematoma (up to 42%), injection site irritation (up to 41%), injection site discoloration (up to 38%), injection site pain (up to 24%), injection site pruritus (up to 19%), injection site warmth (up to 16%)
Common (1% to 10%): Injection site thrombosis (local intravaricose blood clots)
Uncommon (0.1% to 1%): Injection site necrosis, induration, swelling[Ref]


Very rare (less than 0.01%): Anaphylactic shock[Ref]


Very rare (less than 0.01%): Asthma attack, dyspnea, chest discomfort, cough[Ref]


Common (1% to 10%): Neovascularization, hematoma
Uncommon (0.1% to 1%): Thrombophlebitis superficial, phlebitis
Rare (0.01% to 0.1%): Deep vein thrombosis
Very rare (less than 0.01%): Cerebrovascular accident, migraine, pulmonary embolism, syncope vasovagal, circulatory collapse, vasculitis, blood pressure abnormal, heart rate abnormal (tachycardia, bradycardia)
Frequency not reported: Cardiac arrest, palpitations, hot flush[Ref]

Nervous system

Uncommon (0.1% to 1%): Nerve injury
Very rare (less than 0.01%): Headache, paresthesia (local), loss of consciousness, confusional state, dizziness, aphasia, ataxia, hemiparesis, hypoesthesia oral
Frequency not reported: Migraine[Ref]


Common (1% to 10%): Rash, ecchymosis, skin hyperpigmentation
Uncommon (0.1% to 1%): Allergic dermatitis, skin reaction, erythema
Very rare (less than 0.01%): Angioedema, generalized urticaria, hypertrichosis (in the area of sclerotherapy)[Ref]


Very rare (less than 0.01%): dysgeusia, nausea, vomiting[Ref]


Very common (10% or more): Pain in extremity (up to 65%), limb discomfort (up to 32%)[Ref]


Very rare (less than 0.01%): Pyrexia, asthenia, malaise[Ref]


1. Cerner Multum, Inc. "Australian Product Information." O 0

2. "Product Information. Asclera (laureth-9)." BioForm Medical Inc, Franksville,, WI.

Some side effects of Asclera may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.