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Asclera Side Effects

Generic name: polidocanol

Medically reviewed by Last updated on May 16, 2023.

Note: This document contains side effect information about polidocanol. Some dosage forms listed on this page may not apply to the brand name Asclera.

Applies to polidocanol: intravenous foam, intravenous solution.

Serious side effects of Asclera

Along with its needed effects, polidocanol (the active ingredient contained in Asclera) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur while taking polidocanol:

More common

Incidence not known

Get emergency help immediately if any of the following symptoms of overdose occur while taking polidocanol:

Symptoms of overdose

Other side effects of Asclera

Some side effects of polidocanol may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Incidence not known

For Healthcare Professionals

Applies to polidocanol: injectable foam, injectable kit, injectable solution.


Very common (10% or more): Injection site hematoma (up to 42%), injection site irritation (up to 41%), injection site discoloration (up to 38%), injection site pain (up to 24%), injection site pruritus (up to 19%), injection site warmth (up to 16%)

Common (1% to 10%): Injection site thrombosis (local intravaricose blood clots)

Uncommon (0.1% to 1%): Injection site necrosis, induration, swelling[Ref]


Very rare (less than 0.01%): Anaphylactic shock[Ref]


Very rare (less than 0.01%): Asthma attack, dyspnea, chest discomfort, cough[Ref]


Common (1% to 10%): Neovascularization, hematoma

Uncommon (0.1% to 1%): Thrombophlebitis superficial, phlebitis

Rare (0.01% to 0.1%): Deep vein thrombosis

Very rare (less than 0.01%): Cerebrovascular accident, migraine, pulmonary embolism, syncope vasovagal, circulatory collapse, vasculitis, blood pressure abnormal, heart rate abnormal (tachycardia, bradycardia)

Frequency not reported: Cardiac arrest, palpitations, hot flush[Ref]

Nervous system

Uncommon (0.1% to 1%): Nerve injury

Very rare (less than 0.01%): Headache, paresthesia (local), loss of consciousness, confusional state, dizziness, aphasia, ataxia, hemiparesis, hypoesthesia oral

Frequency not reported: Migraine[Ref]


Common (1% to 10%): Rash, ecchymosis, skin hyperpigmentation

Uncommon (0.1% to 1%): Allergic dermatitis, skin reaction, erythema

Very rare (less than 0.01%): Angioedema, generalized urticaria, hypertrichosis (in the area of sclerotherapy)[Ref]


Very rare (less than 0.01%): dysgeusia, nausea, vomiting[Ref]


Very common (10% or more): Pain in extremity (up to 65%), limb discomfort (up to 32%)[Ref]


Very rare (less than 0.01%): Pyrexia, asthenia, malaise[Ref]


1. Cerner Multum, Inc. "Australian Product Information."

2. (2011) "Product Information. Asclera (laureth-9)." BioForm Medical Inc

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.