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Argatroban Side Effects

Medically reviewed by Drugs.com. Last updated on Mar 27, 2024.

Applies to argatroban: intravenous solution.

Serious side effects of Argatroban

Along with its needed effects, argatroban may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur while taking argatroban:

More common

Less common

Rare

For Healthcare Professionals

Applies to argatroban: intravenous solution.

Hematologic

Hematologic side effects including overt bleeding or hemorrhage are the most common complications of argatroban therapy. Major hemorrhagic events reported by the manufacturer include gastrointestinal bleeding (2.3%), intracranial bleeding (about 1% in patients receiving both argatroban and thrombolytic therapy), genitourinary bleeding and hematuria (0.9%), decreases in hemoglobin/hematocrit (0.7%), multisystem hemorrhage/DIC (0.5% ), and limb/below the knee amputation (0.5%). Minor hemorrhagic events reported by the manufacturer include gastrointestinal bleeding (14.4%), genitourinary bleeding and hematuria (11.6%), minor decreases in hemoglobin/hematocrit (10.4%), groin bleeding (5.4%), hemoptysis (2.9%), brachial bleeding (2.4%).[Ref]

In a study of patients given argatroban for the treatment of heparin-induced thrombocytopenia or heparin-induced thrombocytopenia and thrombosis syndrome, one patient experienced intracranial hemorrhage 4 days after the discontinuation of argatroban therapy and following urokinase and oral anticoagulation therapy.[Ref]

Cardiovascular

Cardiovascular side effects include hypotension (7.2%), cardiac arrest (5.8%), ventricular tachycardia (4.8%), atrial fibrillation (3.0%) and cerebrovascular disorder (2.3%).[Ref]

Gastrointestinal

Gastrointestinal side effects include diarrhea (6.2%), nausea (4.8%), vomiting (4.2%), and abdominal pain (2.6%).[Ref]

Respiratory

Respiratory effects include dyspnea (8.1%), pneumonia (3.3%) and coughing (2.8%).[Ref]

General

General side effects include fever (6.9%), sepsis (6.0%) and pain (4.6%).[Ref]

Genitourinary

Genitourinary side effects include urinary tract infection (4.6%).[Ref]

Immunologic

Immunological side effects include infection (3.7%).[Ref]

References

1. (2001) "Product Information. Acova (argatroban)." SmithKline Beecham

2. Swan SK, St. Peter JV, Lambrecht LJ, Hursting MJ (2000) "Comparison of anticoagulant effects and safety of argatroban and heparin in healthy subjects." Pharmacotherapy, 20, p. 756-70

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.