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Amphotericin b liposomal Side Effects

Medically reviewed by Last updated on Dec 22, 2023.

Applies to amphotericin b liposomal: intravenous powder for solution.

Serious side effects

Along with its needed effects, amphotericin b liposomal may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor as soon as possible if any of the following side effects occur while taking amphotericin b liposomal:

More common

Less common


Other side effects

Some side effects of amphotericin b liposomal may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

Less common

For Healthcare Professionals

Applies to amphotericin b liposomal: intravenous powder for injection.


Very common (10% or more): Hypokalemia (51.1%), hyperglycemia (23%), hypomagnesemia (25.9%), hypocalcemia (18.4%), anorexia (14%), hypervolemia (12.2%), hyponatremia (11.6%)

Common (1% to 10%): Hypernatremia, fluid overload, acidosis, hyperchloremia, hyperkalemia, hypermagnesemia, hyperphosphatemia, hypoproteinemia, nonprotein nitrogen (NPN) increased, hyperglycemia[Ref]


Very common (10% or more): Creatinine increased (22.4%), BUN increased (21%)

Common (1% to 10%): Abnormal renal function, acute kidney failure, acute renal failure, kidney failure, toxic nephropathy, increased blood urea

Frequency not reported: Renal insufficiency[Ref]


Very common (10% or more): Anemia (47.9%), leukopenia (15.1%), thrombocytopenia (12.8%)

Common (1% to 10%): Coagulation disorder, ecchymosis, prothrombin decreased, prothrombin increased, thrombocytopenia

Postmarketing reports: Agranulocytosis[Ref]


Very common (10% or more): Hypertension (19.8%), hypotension (14.3%), chest pain (11.1%), phlebitis (10.6%)

Common (1% to 10%): Vasodilatation, arrhythmia, atrial fibrillation, bradycardia, cardiac arrest, cardiomegaly, hemorrhage, postural hypotension, valvular heart disease, vascular disorder[Ref]


Very common (10% or more): Dyspnea (23%), cough increased (17.8%), lung disorder (17.8%), epistaxis (14.9%), pleural effusion (12.5%), rhinitis (11.1%)

Common (1% to 10%): Hypoxia, hyperventilation, respiratory alkalosis, cough, asthma, atelectasis, hemoptysis, hiccup, hyperventilation, lung edema, pharyngitis, pneumonia, respiratory insufficiency, respiratory failure, sinusitis

Uncommon (0.1% to 1%): Hypoxia

Postmarketing reports: Bronchospasm, cyanosis/hypoventilation, pulmonary edema[Ref]


Very common (10% or more): Nausea (39.7%), vomiting (31.8%), diarrhea (30.3%), abdominal pain (19.8%), constipation (15.1%)

Common (1% to 10%): Gastrointestinal hemorrhage, dry mouth/nose, dyspepsia, eructation, flatulence, fecal incontinence, hemorrhoids, gum/oral hemorrhage, hematemesis, ileus, mucositis, rectal disorder, stomatitis, ulcerative stomatitis, amylase increased[Ref]


Very common (10% or more): Fever (89.5%), blood product transfusion reaction (18.4%), peripheral edema (14.6%), edema (14.3%), pain (14%), asthenia (13.1%), chest pain (12%), pyrexia

Common (1% to 10%): Procedural complication, abdomen enlarged, malaise, neck pain, lactate dehydrogenase increased, rigors, influenza-like illness, herpes simplex[Ref]

Nervous system

Very common (10% or more): Headache (19.8%)

Common (1% to 10%): Dizziness, dystonia, coma, convulsion, dysesthesia, dizziness, paresthesia, somnolence, tremor[Ref]


Very common (10% or more): Alkaline phosphatase increased (22.2%), bilirubinemia (18.1%), ALT (SGPT) increased (14.6%), AST (SGOT) increased (12.8%), liver function tests abnormal (12.8%)

Common (1% to 10%): Hepatocellular damage, hepatomegaly, veno-occlusive liver disease[Ref]


Very common (10% or more): Rash (24.8%), pruritus (10.8%)

Common (1% to 10%): Sweating, cellulitis, face edema, petechia, alopecia, dry skin, maculopapular rash, purpura, skin discoloration, skin disorder, skin ulcer, vesiculobullous rash, flushing

Frequency not reported: Angioneurotic edema

Postmarketing reports: Angioedema, erythema, urticaria[Ref]


Very common (10% or more): Hematuria (14%)

Common (1% to 10%): Dysuria, urinary incontinence, vaginal hemorrhage

Postmarketing reports: Hemorrhagic cystitis[Ref]


Very common (10% or more): Insomnia (22.1%), anxiety (13.7%), confusion (12.9%)

Common (1% to 10%): Agitation, depression, hallucinations, nervousness, thinking abnormality[Ref]


Very common (10% or more): Sepsis (14%), infection (12.8%)

Common (1% to 10%): Cell mediated immunologic reaction[Ref]


Very common (10% or more): Chills (48.1%), back pain (12%)

Common (1% to 10%): Arthralgia, bone pain, myalgia

Postmarketing reports: Rhabdomyolysis[Ref]


Common (1% to 10%): Allergic reaction

Uncommon (0.1% to 1%): Anaphylactoid reaction

Frequency not reported: Anaphylactic reactions, hypersensitivity[Ref]


Common (1% to 10%): Conjunctivitis, dry eyes, eye hemorrhage[Ref]


Common (1% to 10%): Injection site inflammation[Ref]


1. Cerner Multum, Inc. UK Summary of Product Characteristics.

2. Cerner Multum, Inc. Australian Product Information.

3. Product Information. AmBisome (amphotericin B liposomal). Astellas Pharma US, Inc. 2022.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.