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Amphotericin b liposomal Side Effects

For the Consumer

Applies to amphotericin b liposomal: intravenous powder for solution

Along with its needed effects, amphotericin b liposomal may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor as soon as possible if any of the following side effects occur while taking amphotericin b liposomal:

More common
  • Chills
  • fever
  • irregular heartbeat
  • muscle cramps or pain
  • unusual tiredness or weakness
Less common
  • Back pain
  • chest pain
  • dark urine
  • difficulty in breathing
  • headache
  • yellowing of eyes or skin
  • Difficulty in swallowing
  • hives
  • itching, especially of feet or hands
  • reddening of skin, especially around ears
  • swelling of eyes, face, or inside of nose
  • unusual tiredness or weakness (sudden and severe)

Some side effects of amphotericin b liposomal may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common
  • Abdominal pain
  • cough
  • diarrhea
  • dizziness
  • nausea
  • vomiting
Less common
  • Skin rash

For Healthcare Professionals

Applies to amphotericin b liposomal: intravenous powder for injection


Very common (10% or more): Hypokalemia (51.1%), hyperglycemia (23%), hypomagnesemia (25.9%), hypocalcemia (18.4%), anorexia (14%), hypervolemia (12.2%), hyponatremia (11.6%)
Common (1% to 10%): Hypernatremia, fluid overload, acidosis, hyperchloremia, hyperkalemia, hypermagnesemia, hyperphosphatemia, hypoproteinemia, nonprotein nitrogen (NPN) increased, hyperglycemia[Ref]


Very common (10% or more): Creatinine increased (22.4%), BUN increased (21%)
Common (1% to 10%): Abnormal renal function, acute kidney failure, acute renal failure, kidney failure, toxic nephropathy, increased blood urea
Frequency not reported: Renal insufficiency[Ref]


Very common (10% or more): Anemia (47.9%), leukopenia (15.1%), thrombocytopenia (12.8%)
Common (1% to 10%): Coagulation disorder, ecchymosis, prothrombin decreased, prothrombin increased, thrombocytopenia
Postmarketing reports: Agranulocytosis[Ref]


Very common (10% or more): Hypertension (19.8%), hypotension (14.3%), chest pain (11.1%), phlebitis (10.6%)
Common (1% to 10%): Vasodilatation, arrhythmia, atrial fibrillation, bradycardia, cardiac arrest, cardiomegaly, hemorrhage, postural hypotension, valvular heart disease, vascular disorder[Ref]


Very common (10% or more): Dyspnea (23%), cough increased (17.8%), lung disorder (17.8%), epistaxis (14.9%), pleural effusion (12.5%), rhinitis (11.1%)
Common (1% to 10%): Hypoxia, hyperventilation, respiratory alkalosis, cough, asthma, atelectasis, hemoptysis, hiccup, hyperventilation, lung edema, pharyngitis, pneumonia, respiratory insufficiency, respiratory failure, sinusitis
Uncommon (0.1% to 1%): Hypoxia
Postmarketing reports: Bronchospasm, cyanosis/hypoventilation, pulmonary edema[Ref]


Very common (10% or more): Nausea (39.7%), vomiting (31.8%), diarrhea (30.3%), abdominal pain (19.8%), constipation (15.1%)
Common (1% to 10%): Gastrointestinal hemorrhage, dry mouth/nose, dyspepsia, eructation, flatulence, fecal incontinence, hemorrhoids, gum/oral hemorrhage, hematemesis, ileus, mucositis, rectal disorder, stomatitis, ulcerative stomatitis, amylase increased[Ref]


Very common (10% or more): Fever (89.5%), blood product transfusion reaction (18.4%), peripheral edema (14.6%), edema (14.3%), pain (14%), asthenia (13.1%), chest pain (12%), pyrexia
Common (1% to 10%): Procedural complication, abdomen enlarged, malaise, neck pain, lactate dehydrogenase increased, rigors, influenza-like illness, herpes simplex[Ref]

Nervous system

Very common (10% or more): Headache (19.8%)
Common (1% to 10%): Dizziness, dystonia, coma, convulsion, dysesthesia, dizziness, paresthesia, somnolence, tremor[Ref]


Very common (10% or more): Alkaline phosphatase increased (22.2%), bilirubinemia (18.1%), ALT (SGPT) increased (14.6%), AST (SGOT) increased (12.8%), liver function tests abnormal (12.8%)
Common (1% to 10%): Hepatocellular damage, hepatomegaly, veno-occlusive liver disease[Ref]


Very common (10% or more): Rash (24.8%), pruritus (10.8%)
Common (1% to 10%): Sweating, cellulitis, face edema, petechia, alopecia, dry skin, maculopapular rash, purpura, skin discoloration, skin disorder, skin ulcer, vesiculobullous rash, flushing
Frequency not reported: Angioneurotic edema
Postmarketing reports: Angioedema, erythema, urticaria[Ref]


Very common (10% or more): Hematuria (14%)
Common (1% to 10%): Dysuria, urinary incontinence, vaginal hemorrhage
Postmarketing reports: Hemorrhagic cystitis[Ref]


Very common (10% or more): Insomnia (22.1%), anxiety (13.7%), confusion (12.9%)
Common (1% to 10%): Agitation, depression, hallucinations, nervousness, thinking abnormality[Ref]


Very common (10% or more): Sepsis (14%), infection (12.8%)
Common (1% to 10%): Cell mediated immunologic reaction[Ref]


Very common (10% or more): Chills (48.1%), back pain (12%)
Common (1% to 10%): Arthralgia, bone pain, myalgia
Postmarketing reports: Rhabdomyolysis[Ref]


Common (1% to 10%): Allergic reaction
Uncommon (0.1% to 1%): Anaphylactoid reaction
Frequency not reported: Anaphylactic reactions, hypersensitivity[Ref]


Common (1% to 10%): Conjunctivitis, dry eyes, eye hemorrhage[Ref]


Common (1% to 10%): Injection site inflammation[Ref]


1. Cerner Multum, Inc. "Australian Product Information." O 0

2. "Product Information. AmBisome (amphotericin B liposomal)." Astellas Pharma US, Inc, Deerfield, IL.

3. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0

Some side effects of amphotericin b liposomal may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.