Skip to main content

Acthrel Side Effects

Generic name: corticorelin

Medically reviewed by Last updated on Dec 25, 2021.

Note: This document contains side effect information about corticorelin. Some of the dosage forms listed on this page may not apply to the brand name Acthrel.

For the Consumer

Applies to corticorelin: intravenous powder for solution

Side effects requiring immediate medical attention

Along with its needed effects, corticorelin (the active ingredient contained in Acthrel) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur while taking corticorelin:

Incidence not known

  • Difficult or labored breathing
  • feeling of warmth
  • hives or welts, itching, or skin rash
  • large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
  • redness of the skin
  • redness of the face, neck, arms, and occasionally, upper chest
  • tightness in the chest

Get emergency help immediately if any of the following symptoms of overdose occur while taking corticorelin:

Symptoms of overdose

  • Difficult or labored breathing
  • severe redness of the face

For Healthcare Professionals

Applies to corticorelin: intravenous powder for injection


Very common (10% or more): Flushing of the face, neck, and upper chest (16%)

Common (1% to 10%): Asystole

Frequency not reported: Prolonged flushing, tachycardia, hypotension, "chest compression" or tightness, increases in heart rate, decreases in blood pressure, transient flushing[Ref]


The most commonly reported side effects were flushing of the face, neck, and upper chest.[Ref]

Nervous system

Common (1% to 10%): "Absence-like" loss of consciousness, grand mal epileptic seizure[Ref]


Common (1% to 10%): Urge to take a deep breath

Frequency not reported: Dyspnea[Ref]

More about Acthrel (corticorelin)

Patient resources

Professional resources

Related treatment guides


1. "Product Information. Acthrel (corticorelin)." Ferring Laboratories Inc, Tarrytown, NY.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.