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Tetrahydrozoline (Nasal)

Medically reviewed by Last updated on Oct 20, 2020.


(tet ra hye DROZ a leen)

Index Terms

  • Tetrahydrozoline HCl
  • Tetrahydrozoline Hydrochloride
  • Tetryzoline

Dosage Forms

Excipient information presented when available (limited, particularly for generics); consult specific product labeling. [DSC] = Discontinued product

Solution, Nasal, as hydrochloride:

Tyzine: 0.05% (15 mL [DSC]) [contains benzalkonium chloride, edetate disodium]

Brand Names: U.S.

  • Tyzine [DSC]

Pharmacologic Category

  • Adrenergic Agonist Agent
  • Decongestant
  • Imidazoline Derivative


Stimulates alpha-adrenergic receptors in the arterioles of the nasal mucosa to produce vasoconstriction

Onset of Action

Decongestant: 4-8 hours

Use: Labeled Indications

Symptomatic relief of nasal congestion


Hypersensitivity to tetrahydrozoline or any component of the formulation. The 0.5% solution is contraindicated in children <2 years of age. The 0.1% solution is contraindicated in children <6 years of age.

Dosing: Adult

Nasal congestion: Intranasal: Instill 2-4 drops or 3-4 sprays of 0.1% solution into each nostril every 3-4 hours as needed, no more frequently than every 3 hours

Dosing: Geriatric

Refer to adult dosing.

Dosing: Pediatric

Nasal congestion: Intranasal:

Children 2-6 years: Instill 2-3 drops of 0.05% solution into each nostril every 4-6 hours as needed, no more frequently than every 3 hours

Children >6 years: Refer to adult dosing.


Do not use if solution changes color or becomes cloudy. Store below 30°C (86°F).

Drug Interactions

Esketamine: Decongestants (Nasally Administered) may diminish the therapeutic effect of Esketamine. Management: Patients who require a nasal decongestant on an esketamine dosing day should administer the nasal decongestant at least 1 hour before esketamine. Consider therapy modification

Monoamine Oxidase Inhibitors: May enhance the hypertensive effect of Tetrahydrozoline (Nasal). Avoid combination

Adverse Reactions

The following adverse drug reactions and incidences are derived from product labeling unless otherwise specified.

>10%: Respiratory: Sneezing, stinging sensation of the nose

1% to 10%:

Cardiovascular: Hypertension, palpitations, tachycardia

Central nervous system: Headache

Neuromuscular & skeletal: Tremor

Ophthalmic: Blurred vision


Concerns related to adverse effects:

• Somnolence: Profound sedation may occur in children following overdose. This may be accompanied by diaphoresis, hypotension, and/or shock. Do not exceed recommended dosages.

Disease-related concerns:

• Cardiovascular disease: Use with caution in patients with cardiovascular disease, including hypertension and coronary artery disease.

• Endocrine disorders: Use with caution in patients with endocrine disorders, including diabetes and hyperthyroidism.

Other warnings/precautions:

• Appropriate use: For intranasal use only.

• Accidental ingestion: Accidental ingestion by children of over-the-counter (OTC) imidazoline-derivative eye drops and nasal sprays may result in serious harm. Serious adverse reactions (eg, coma, bradycardia, respiratory depression, sedation) requiring hospitalization have been reported in children ≤5 years of age who had ingested even small amounts (eg, 1-2 mL). Contact a poison control center and seek emergency medical care immediately for accidental ingestion (FDA Drug Safety Communication, 2012).

Monitoring Parameters

Blood pressure, heart rate, symptom response

Pregnancy Risk Factor C Pregnancy Considerations

Animal reproduction studies have not been conducted.

Patient Education

What is this drug used for?

• It is used to treat nose stuffiness.

All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away:

• Sneezing

• Burning

• Stinging

• Nasal dryness

WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect:

• Severe loss of strength and energy

• Chest pain

• Fast heartbeat

• Passing out

• Abnormal heartbeat

• Tremors

• Severe headache

• Severe dizziness

• Pale skin

• Sweating a lot

• Trouble sleeping

• Fatigue

• Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing, swallowing, or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.

Note: This is not a comprehensive list of all side effects. Talk to your doctor if you have questions.

Consumer Information Use and Disclaimer: This information should not be used to decide whether or not to take this medicine or any other medicine. Only the healthcare provider has the knowledge and training to decide which medicines are right for a specific patient. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a limited summary of general information about the medicine's uses from the patient education leaflet and is not intended to be comprehensive. This limited summary does NOT include all information available about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not intended to provide medical advice, diagnosis or treatment and does not replace information you receive from the healthcare provider. For a more detailed summary of information about the risks and benefits of using this medicine, please speak with your healthcare provider and review the entire patient education leaflet.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.