Medically reviewed on March 25, 2018
(tet ra hye DROZ a leen)
- Tetrahydrozoline HCl
- Tetrahydrozoline Hydrochloride
Excipient information presented when available (limited, particularly for generics); consult specific product labeling. [DSC] = Discontinued product
Solution, Nasal, as hydrochloride:
Tyzine: 0.05% (15 mL [DSC]); 0.1% (15 mL [DSC], 30 mL [DSC]) [contains benzalkonium chloride, edetate disodium]
Brand Names: U.S.
- Tyzine [DSC]
- Adrenergic Agonist Agent
- Imidazoline Derivative
Stimulates alpha-adrenergic receptors in the arterioles of the nasal mucosa to produce vasoconstriction
Onset of Action
Decongestant: 4-8 hours
Use: Labeled Indications
Symptomatic relief of nasal congestion
Hypersensitivity to tetrahydrozoline or any component of the formulation. The 0.5% solution is contraindicated in children <2 years of age. The 0.1% solution is contraindicated in children <6 years of age.
Nasal congestion: Intranasal: Instill 2-4 drops or 3-4 sprays of 0.1% solution into each nostril every 3-4 hours as needed, no more frequently than every 3 hours
Refer to adult dosing.
Nasal congestion: Intranasal:
Children 2-6 years: Instill 2-3 drops of 0.05% solution into each nostril every 4-6 hours as needed, no more frequently than every 3 hours
Children >6 years: Refer to adult dosing.
Do not use if solution changes color or becomes cloudy. Store below 30°C (86°F).
Monoamine Oxidase Inhibitors: May enhance the hypertensive effect of Tetrahydrozoline (Nasal). Avoid combination
>10%: Respiratory: Sneezing, stinging sensation of the nose
1% to 10%:
Cardiovascular: Hypertension, palpitations, tachycardia
Central nervous system: Headache
Neuromuscular & skeletal: Tremor
Ophthalmic: Blurred vision
Concerns related to adverse effects:
• Somnolence: Profound sedation may occur in children following overdose. This may be accompanied by diaphoresis, hypotension, and/or shock. Do not exceed recommended dosages.
• Cardiovascular disease: Use with caution in patients with cardiovascular disease, including hypertension and coronary artery disease.
• Endocrine disorders: Use with caution in patients with endocrine disorders, including diabetes and hyperthyroidism.
• Appropriate use: For intranasal use only.
• Accidental ingestion: Accidental ingestion by children of over-the-counter (OTC) imidazoline-derivative eye drops and nasal sprays may result in serious harm. Serious adverse reactions (eg, coma, bradycardia, respiratory depression, sedation) requiring hospitalization have been reported in children ≤5 years of age who had ingested even small amounts (eg, 1-2 mL). Contact a poison control center and seek emergency medical care immediately for accidental ingestion (FDA Drug Safety Communication, 2012).
Blood pressure, heart rate, symptom response
Pregnancy Risk Factor
Animal reproduction studies have not been conducted.
• Discuss specific use of drug and side effects with patient as it relates to treatment. (HCAHPS: During this hospital stay, were you given any medicine that you had not taken before? Before giving you any new medicine, how often did hospital staff tell you what the medicine was for? How often did hospital staff describe possible side effects in a way you could understand?)
• Patient may experience sneezing, burning, stinging, or nasal dryness. Have patient report immediately to prescriber severe loss of strength and energy, angina, tachycardia, passing out, abnormal heartbeat, tremors, severe headache, severe dizziness, pale skin, sweating a lot, insomnia, or fatigue (HCAHPS).
• Educate patient about signs of a significant reaction (eg, wheezing; chest tightness; fever; itching; bad cough; blue skin color; seizures; or swelling of face, lips, tongue, or throat). Note: This is not a comprehensive list of all side effects. Patient should consult prescriber for additional questions.
Intended Use and Disclaimer: Should not be printed and given to patients. This information is intended to serve as a concise initial reference for health care professionals to use when discussing medications with a patient. You must ultimately rely on your own discretion, experience, and judgment in diagnosing, treating, and advising patients.
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
More about tetrahydrozoline nasal
- Tetrahydrozoline nasal Side Effects
- During Pregnancy
- Drug Interactions
- Support Group
- 0 Reviews
- Drug class: nasal antihistamines and decongestants
Other brands: Tyzine