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Tetrahydrozoline (Nasal)

Pronunciation

(tet ra hye DROZ a leen)

Index Terms

  • Tetrahydrozoline HCl
  • Tetrahydrozoline Hydrochloride
  • Tetryzoline

Dosage Forms

Excipient information presented when available (limited, particularly for generics); consult specific product labeling. [DSC] = Discontinued product

Solution, Nasal, as hydrochloride:

Tyzine: 0.05% (15 mL); 0.1% (15 mL [DSC], 30 mL [DSC]) [contains benzalkonium chloride, edetate disodium]

Brand Names: U.S.

  • Tyzine

Pharmacologic Category

  • Adrenergic Agonist Agent
  • Decongestant
  • Imidazoline Derivative

Pharmacology

Stimulates alpha-adrenergic receptors in the arterioles of the nasal mucosa to produce vasoconstriction

Onset of Action

Decongestant: 4-8 hours

Use: Labeled Indications

Symptomatic relief of nasal congestion

Contraindications

Hypersensitivity to tetrahydrozoline or any component of the formulation. The 0.5% solution is contraindicated in children <2 years of age. The 0.1% solution is contraindicated in children <6 years of age.

Dosing: Adult

Nasal congestion: Intranasal: Instill 2-4 drops or 3-4 sprays of 0.1% solution into each nostril every 3-4 hours as needed, no more frequently than every 3 hours

Dosing: Geriatric

Refer to adult dosing.

Dosing: Pediatric

Nasal congestion: Intranasal:

Children 2-6 years: Instill 2-3 drops of 0.05% solution into each nostril every 4-6 hours as needed, no more frequently than every 3 hours

Children >6 years: Refer to adult dosing.

Storage

Do not use if solution changes color or becomes cloudy. Store below 30°C (86°F).

Drug Interactions

MAO Inhibitors: May enhance the hypertensive effect of Tetrahydrozoline (Nasal). Avoid combination

Adverse Reactions

>10%: Respiratory: Sneezing, stinging sensation of the nose

1% to 10%:

Cardiovascular: Hypertension, palpitations, tachycardia

Central nervous system: Headache

Neuromuscular & skeletal: Tremor

Ophthalmic: Blurred vision

Warnings/Precautions

Concerns related to adverse effects:

• Somnolence: Profound sedation may occur in children following overdose. This may be accompanied by diaphoresis, hypotension, and/or shock. Do not exceed recommended dosages.

Disease-related concerns:

• Cardiovascular disease: Use with caution in patients with cardiovascular disease, including hypertension and coronary artery disease.

• Endocrine disorders: Use with caution in patients with endocrine disorders, including diabetes and hyperthyroidism.

Other warnings/precautions:

• Appropriate use: For intranasal use only.

• Accidental ingestion: Accidental ingestion by children of over-the-counter (OTC) imidazoline-derivative eye drops and nasal sprays may result in serious harm. Serious adverse reactions (eg, coma, bradycardia, respiratory depression, sedation) requiring hospitalization have been reported in children ≤5 years of age who had ingested even small amounts (eg, 1-2 mL). Contact a poison control center and seek emergency medical care immediately for accidental ingestion (FDA Drug Safety Communication, 2012).

Monitoring Parameters

Blood pressure, heart rate, symptom response

Pregnancy Risk Factor

C

Pregnancy Considerations

Animal reproduction studies have not been conducted.

Patient Education

• Discuss specific use of drug and side effects with patient as it relates to treatment. (HCAHPS: During this hospital stay, were you given any medicine that you had not taken before? Before giving you any new medicine, how often did hospital staff tell you what the medicine was for? How often did hospital staff describe possible side effects in a way you could understand?)

• Patient may experience rhinitis, sneezing, burning, stinging, dry mouth, or nasal dryness. Have patient report immediately to prescriber angina, tachycardia, passing out, arrhythmia, tremors, severe headache, severe dizziness, pale skin, sweating a lot, or fatigue (HCAHPS).

• Educate patient about signs of a significant reaction (eg, wheezing; chest tightness; fever; itching; bad cough; blue skin color; seizures; or swelling of face, lips, tongue, or throat). Note: This is not a comprehensive list of all side effects. Patient should consult prescriber for additional questions.

Intended Use and Disclaimer: Should not be printed and given to patients. This information is intended to serve as a concise initial reference for health care professionals to use when discussing medications with a patient. You must ultimately rely on your own discretion, experience, and judgment in diagnosing, treating, and advising patients.

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