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Olopatadine (Nasal)

Medically reviewed by Drugs.com. Last updated on Jun 5, 2020.

Pronunciation

(oh la PAT a deen)

Index Terms

  • Olopatadine HCl
  • Olopatadine Hydrochloride

Dosage Forms

Excipient information presented when available (limited, particularly for generics); consult specific product labeling.

Solution, Nasal:

Patanase: 0.6% (30.5 g) [contains benzalkonium chloride, edetate disodium]

Generic: 0.6% (30.5 g)

Brand Names: U.S.

  • Patanase

Pharmacologic Category

  • Histamine H1 Antagonist
  • Histamine H1 Antagonist, Second Generation
  • Piperidine Derivative

Pharmacology

Selective histamine H1-antagonist; inhibits release of histamine from mast cells.

Metabolism

Not extensively metabolized

Excretion

Urine (60% to 70%, mostly as unchanged drug); feces (17%)

Onset of Action

30 minutes in seasonal allergy patients

Time to Peak

Serum: 15 minutes to 2 hours

Half-Life Elimination

8-12 hours

Protein Binding

~55% (primarily albumin)

Special Populations: Children

6 to 11 years of age

Mean Cmax was ~2-fold less when compared with adults (intranasal).

Special Populations: Gender

Cmax and AUC were 40% and 27% higher, respectively, in women compared with men (intranasal).

Use: Labeled Indications

Treatment of the symptoms of seasonal allergic rhinitis

Contraindications

There are no contraindications listed in the manufacturer's labeling.

Dosing: Adult

Seasonal allergic rhinitis: Intranasal: 2 sprays into each nostril twice daily

Dosing: Geriatric

Refer to adult dosing.

Dosing: Pediatric

Seasonal allergic rhinitis: Intranasal:

Children 6-11 years: 1 spray into each nostril twice daily

Children ≥12 years and Adolescents: Refer to adult dosing.

Administration

For intranasal use only. Before initial use of the nasal spray, the delivery system should be primed with 5 sprays or until a fine mist appears. If 7 or more days have elapsed since last use, the delivery system should be reprimed with 2 sprays or until a fine mist appears. Blow nose to clear nostrils. Keep head tilted downward when spraying. Insert applicator into nostril, keeping bottle upright, and close off the other nostril. Breathe in through nose. While inhaling, press pump to release spray. Alternate sprays between nostrils. After each use, wipe the spray tip with a clean tissue or cloth.

Storage

Store at 4°C to 25°C (39°F to 77°F).

Drug Interactions

There are no known significant interactions.

Adverse Reactions

>10%:

Central nervous system: Bitter taste (13%; children: 1%)

Respiratory: Epistaxis (3% to 25%)

1% to 10%:

Central nervous system: Depression (2%), drowsiness (1%), fatigue (1%)

Dermatologic: Skin rash (children: 1%)

Endocrine & metabolic: Weight gain (1%)

Gastrointestinal: Xerostomia (1%)

Genitourinary: Urinary tract infection (1%)

Infection: Influenza (1%)

Neuromuscular & skeletal: Increased creatine phosphokinase (1%)

Respiratory: Nasal mucosa ulcer (9% to 10%), upper respiratory tract infection (children: 3%), pharyngolaryngeal pain (2%), post nasal drip (2%), cough (1%), throat irritation (1%)

<1%, postmarketing, and/or case reports: Altered sense of smell, anosmia, dizziness, dysgeusia, nasal discomfort, oropharyngeal pain

Warnings/Precautions

Concerns related to adverse effects:

• CNS depression: May cause drowsiness in some patients; instruct patient to use caution when driving or operating machinery. Effects may be additive with CNS depressants and/or ethanol.

• Nasal ulcerations: Periodically examine nasal mucosa for ulceration and consider discontinuing if ulceration occurs.

Monitoring Parameters

Observe patients periodically for adverse nasal effects (eg, ulceration, perforation).

Pregnancy Risk Factor

C

Pregnancy Considerations

Other agents may be preferred for the treatment of allergic rhinitis in pregnant women (BSACI [Scadding 2017]).

Patient Education

What is this drug used for?

• It is used to ease allergy signs.

All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away:

• Headache

• Sore throat

• Bad taste

WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect:

• Nasal sores

• Severe nasal irritation

• Noisy breathing

• Severe nosebleeds

• Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing, swallowing, or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.

Note: This is not a comprehensive list of all side effects. Talk to your doctor if you have questions.

Consumer Information Use and Disclaimer: This information should not be used to decide whether or not to take this medicine or any other medicine. Only the healthcare provider has the knowledge and training to decide which medicines are right for a specific patient. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a limited summary of general information about the medicine's uses from the patient education leaflet and is not intended to be comprehensive. This limited summary does NOT include all information available about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not intended to provide medical advice, diagnosis or treatment and does not replace information you receive from the healthcare provider. For a more detailed summary of information about the risks and benefits of using this medicine, please speak with your healthcare provider and review the entire patient education leaflet.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.