Medically reviewed by Drugs.com. Last updated on Jul 5, 2019.
(moxs i FLOKS a sin)
- Moxifloxacin Hydrochloride
Excipient information presented when available (limited, particularly for generics); consult specific product labeling.
Moxeza: 0.5% (3 mL)
Vigamox: 0.5% (3 mL)
Generic: 0.5% (3 mL)
Brand Names: U.S.
- Antibiotic, Fluoroquinolone
- Antibiotic, Ophthalmic
Moxifloxacin is a DNA gyrase inhibitor, and also inhibits topoisomerase IV. DNA gyrase (topoisomerase II) is an essential bacterial enzyme that maintains the superhelical structure of DNA. DNA gyrase is required for DNA replication and transcription, DNA repair, recombination, and transposition; inhibition is bactericidal.
Minimal systemic absorption; resulting serum concentration was 0.02% of that achieved with oral formulation
Use: Labeled Indications
Bacterial conjunctivitis: Treatment of bacterial conjunctivitis caused by susceptible organisms: Acinetobacter lwoffii, Aerococcus viridams, Chlamydia trachomatis, Corynebacterium spp, Cutibacterium (formerly Propionibacterium) acnes, Enterococcus faecalis, Escherichia coli, Haemophilus influenzae, Haemophilus parainfluenzae, Klebsiella pneumoniae, Micrococcus luteus, Staphylococcus arlettae, Staphylococcus aureus, Staphylococcus capitis, Staphylococcus epidermidis, Staphylococcus haemolyticus, Staphylococcus hominis, Staphylococcus saprophyticus, Staphylococcus warneri, Streptococcus mitis, Streptococcus parasanguinis, Streptococcus pneumoniae, Viridans group streptococci.
Off Label Uses
Surgical (ophthalmic) prophylaxis
Based on the American Society of Health-System Pharmacists (ASHP), the Infectious Diseases Society of America (IDSA), the Surgical Infection Society (SIS), and the Society of Healthcare Epidemiology of America (SHEA) guidelines for antimicrobial prophylaxis in surgery, moxifloxacin (ophthalmic) is recommended for ophthalmic surgical prophylaxis.
Moxeza ophthalmic solution: There are no contraindications listed in manufacturer's labeling
Vigamox: Hypersensitivity to moxifloxacin, other quinolone antibiotics, or any component of the formulation
Bacterial conjunctivitis: Ophthalmic:
Moxeza: Instill 1 drop into affected eye(s) 2 times daily for 7 days.
Vigamox: Instill 1 drop into affected eye(s) 3 times daily for 7 days.
Surgical prophylaxis (off-label use): Instill 1 drop into operative eye every 5 to 15 minutes for five doses within the hour prior to the start of the procedure (ASHP/IDSA/SIS/SHEA [Bratzler 2013]). Note: Prophylactic administration has ranged from preoperatively (including day of surgery only to 1 to 3 days preoperatively), intraoperatively, at end of procedure, and postoperatively. However, no specific recommendations beyond immediate preoperative use, including duration of prophylaxis, can be made due to insufficient evidence. A total duration (pre- and postoperatively) of up to 15 days has been reported (ASHP/IDSA/SIS/SHEA [Bratzler 2013]; Freitas 2007; Speaker 2009).
Refer to adult dosing.
Bacterial conjunctivitis: Ophthalmic:
Moxeza: Infants ≥4 months, Children, and Adolescents: Instill 1 drop into affected eye(s) 2 times daily for 7 days
Vigamox: Infants, Children, and Adolescents: Instill 1 drop into affected eye(s) 3 times daily for 7 days
For topical ophthalmic use only; not for injection. Avoid touching tip of applicator to eye or other surfaces.
Store at 2°C to 25°C (36°F to 77°F).
There are no known significant interactions.
1% to 6%: Ophthalmic: Eye irritation (1% to 2%), conjunctivitis, decreased visual acuity, eye discomfort, eye pain, eye pruritus, lacrimation, ocular hyperemia, subconjunctival hemorrhage, xerophthalmia
Concerns related to adverse effects:
• Hypersensitivity reactions: Severe hypersensitivity reactions, including anaphylaxis, angioedema, and dermatologic reactions, have been reported with systemic use of moxifloxacin. Discontinue use if an allergic reaction occurs.
• Superinfection: Prolonged use may lead to overgrowth of nonsusceptible organisms, including fungi. If superinfection occurs, discontinue use and institute appropriate alternative therapy.
Dosage form specific issues:
• Ophthalmic solution: For topical ophthalmic use only. Not for subconjunctival injection or for direct introduction into the anterior chamber of the eye. Contact lenses should not be worn during therapy.
Pregnancy Risk Factor
When administered orally or IV, moxifloxacin crosses the placenta (Ozyüncü 2010a; Ozyüncü 2010b). The amount of moxifloxacin available systemically following topical application of the ophthalmic drops is significantly less in comparison to oral or IV doses. If ophthalmic agents are needed during pregnancy, the minimum effective dose should be used in combination with punctal occlusion for 3 to 5 minutes after application to decrease potential exposure to the fetus (Samples 1988).
• Discuss specific use of drug and side effects with patient as it relates to treatment. (HCAHPS: During this hospital stay, were you given any medicine that you had not taken before? Before giving you any new medicine, how often did hospital staff tell you what the medicine was for? How often did hospital staff describe possible side effects in a way you could understand?)
• Patient may experience short-term pain, watery eyes, or dry eyes. Have patient report immediately to prescriber vision changes, eye pain, or severe eye irritation (HCAHPS).
• Educate patient about signs of a significant reaction (eg, wheezing; chest tightness; fever; itching; bad cough; blue skin color; seizures; or swelling of face, lips, tongue, or throat). Note: This is not a comprehensive list of all side effects. Patient should consult prescriber for additional questions.
Intended Use and Disclaimer: Should not be printed and given to patients. This information is intended to serve as a concise initial reference for health care professionals to use when discussing medications with a patient. You must ultimately rely on your own discretion, experience, and judgment in diagnosing, treating, and advising patients.
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
More about moxifloxacin ophthalmic
- Side Effects
- During Pregnancy or Breastfeeding
- Dosage Information
- Pricing & Coupons
- En Español
- 22 Reviews
- Drug class: ophthalmic anti-infectives
- FDA Alerts (2)