Medically reviewed by Drugs.com. Last updated on Oct 10, 2020.
(LYE doe kane)
- Lidocaine Hydrochloride
- Lignocaine Hydrochloride
Excipient information presented when available (limited, particularly for generics); consult specific product labeling.
Gel, Ophthalmic, as hydrochloride [preservative free]:
Akten: 3.5% (1 mL)
Brand Names: U.S.
- Local Anesthetic
- Local Anesthetic, Ophthalmic
Local anesthetics block both the initiation and conduction of nerve impulses by decreasing the neuronal membrane's permeability to sodium ions, which results in inhibition of depolarization with resultant blockade of conduction.
Onset of Action
20 seconds to 5 minutes (median: 40 seconds)
Duration of Action
5 to 30 minutes (median: 15 minutes)
Use: Labeled Indications
Anesthesia, ocular: To provide local anesthesia to ocular surface during ophthalmologic procedures
There are no contraindications listed in the manufacturer's labeling
Anesthesia, ocular: Apply 2 drops to ocular surface in area where procedure will occur; may reapply to maintain effect.
Refer to adult dosing.
Anesthesia, ocular: Ophthalmic gel: Children and Adolescents: Apply 2 drops to ocular surface in area where procedure to occur; may reapply to maintain effect
Store at 15°C to 25°C (59°F to 77°F). Protect from light. Discard after use.
Bupivacaine: Local Anesthetics may enhance the adverse/toxic effect of Bupivacaine. Management: Avoid using any additional local anesthetics within 96 hours after insertion of the bupivacaine implant (Xaracoll). Monitor therapy
Methemoglobinemia Associated Agents: May enhance the adverse/toxic effect of Local Anesthetics. Specifically, the risk for methemoglobinemia may be increased. Monitor therapy
The following adverse drug reactions and incidences are derived from product labeling unless otherwise specified.
Frequency not defined.
Central Nervous System: Localized burning
Ophthalmic: Conjunctival hyperemia, diplopia, epithelial keratopathy, visual disturbance
Concerns related to adverse effects:
• Corneal ulceration: Prolonged use may cause permanent corneal ulceration and/or opacification with loss of vision.
Dosage form specific issues:
• Appropriate use: For ophthalmic use only; not for injection.
Pregnancy Risk Factor
Adverse events were not observed in animal reproduction studies. Although systemic exposure is not expected following application of the ophthalmic gel, cumulative exposure from all routes of administration should be considered.
What is this drug used for?
• It is used during eye surgery.
All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away:
WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect:
• Vision changes
• Eye pain
• Severe eye irritation
• Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing, swallowing, or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.
Note: This is not a comprehensive list of all side effects. Talk to your doctor if you have questions.
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Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
More about lidocaine ophthalmic
- Side Effects
- During Pregnancy or Breastfeeding
- Dosage Information
- Drug Interactions
- Drug class: ophthalmic anesthetics
Other brands: Akten