Meadowsweet

Scientific Name(s): Filipendula ulmaria (L.) Maxim.
Common Name(s): Bridewort, Dropwort, Lady of the meadow, Meadowsweet, Queen of the meadow

Botany

Meadowsweet is an herbaceous, perennial shrub growing up to 2 m tall. The plant is native to Europe, but also grows in North America, preferring damp, moist soil. The erect stem is red-marbled and hollow and the plant has 3 to 9 pairs of dark-green, toothed, dentate leaves. Meadowsweet's aromatic, ornamental flowers are creamy and yellow-white with 5 petals. The flowers are 5 mm in length and have an aroma reminiscent of wintergreen oil. The medicinal product consists of flower petals and some unopened buds.1, 2, 3, 4, 5, 6, 7, 8

History

In 1597, botanist John Gerard noted that the smell of meadowsweet "delighteth the senses." In 1652, English physician Nicholas Culpeper wrote about the plant's therapeutic effects on the stomach.5 In 1682, meadowsweet was mentioned as a Dutch herbal. In Holland, the plant was called filipendula, while in the rest of Europe, it was known as spiraea. Queen Elizabeth I adorned her apartments with meadowsweet. The flowers were used to flavor alcoholic beverages in England and Scandinavian countries.8 In the Middle Ages, meadowsweet was known as "meadwort" because it was used to flavor mead, an alcoholic drink made by fermenting honey and fruit juices.5

In 1838, salicylic acid was isolated from the plant, and in the 1890s, it was first synthesized to make aspirin.5 The word "aspirin" is derived from spirin, based on meadowsweet's former scientific name Spiraea.8

The plant was used in folk medicine for cancer, tumors, and rheumatism, and as a diuretic.7, 9 Today, it is used as a digestive remedy, as supportive therapy for colds, for analgesia, and for other indications.

Chemistry

Flavonoids in meadowsweet include the flavonol glycosides rutin, hyperin, and spiraeoside.4 Spiraeoside has been evaluated in the plant's flowers.10 Glycoside spiraein (quercitin glycoside and salicylaldehyde primveroside) is present, as are phenolic glycosides including gaultherin.3, 8 A phenolic glycoside from meadowsweet flowers has been reported.11 Quercetin and kaempferol derivatives have also been found in the plant, and hyperoside is present primarily in the leaves and stalks.4 A report is available on 7 flavonoids isolated from meadowsweet flowers, fruits, leaves, and stalks.12

Constituents in meadowsweet include 10% to 20% of hexahydroxydiphenic acid esters of glucose and tannins.4, 5, 7, 8 One report found tannin content to be high compared with that of other Rosaceae species.13

The essential oil contains primarily salicylaldehyde (75%), as well as phenylethyl alcohol, benzyl alcohol, anisaldehyde, methyl salicylate, salicin, gaultherin, spiraein, spiraeoside, heliotropin, phenyl acetate, and vanillin.2, 4, 9

Salicylates in the plant include salicylic aldehyde, salicylic acid, salicin, methyl salicylate, and others.2, 4, 7, 9 High-performance liquid chromatography and thin-layer chromatography assays for meadowsweet salicylates have been developed.14

Meadowsweet flowers contain heparin, which binds to the plant's proteins, forming a complex.15 Heparin isolated from meadowsweet shows some similarity to heparin of animal origin.16

Other constituents in meadowsweet include mucilage, carbohydrates, ascorbic acid, sugars, and minerals.2, 8

A phytochemical study of meadowsweet is available.17

Uses and Pharmacology

Colds

Meadowsweet is used for supportive therapy in colds, probably because of its proposed analgesic, anti-inflammatory, and antipyretic actions.3, 4, 6, 8 The roots have been used to treat respiratory symptoms such as hoarseness, cough, and wheezing.9

Animal data

There are no animal data regarding the use of meadowsweet for the treatment of colds.

Clinical data

There are no clinical data regarding the use of meadowsweet for the treatment of colds.

Ulcers

The plant is used as a digestive remedy for acid indigestion or peptic ulcers. It protects the inner lining of the stomach while providing the anti-inflammatory benefits of salicylates.5

Animal data

A reduction in ulcerogenic action has been documented in rats, promoting the healing of induced chronic ulcers and preventing acetylsalicylic acid–induced lesions in the stomach.18 However, meadowsweet has been reported to potentiate ulcerogenic properties in animals.2

Clinical data

There are no clinical data regarding the use of meadowsweet for the treatment of ulcers.

Arthritis/Rheumatism

Meadowsweet may be beneficial in treating joint pain.5 Meadowsweet may also improve the condition of connective joint tissue.8 In folk medicine, meadowsweet was used as a treatment for rheumatism and arthritis.4

Animal data

There are no animal data regarding the use of meadowsweet for the treatment of arthritis/rheumatism.

Clinical data

There are no clinical data regarding the use of meadowsweet for the treatment of arthritis/rheumatism.

Antioxidant

Aqueous and ethanolic extracts of the above-ground parts of meadowsweet were found to possess antioxidant activity.19

Animal data

In a murine model, 100 mg/kg of meadowsweet extract given intragastrically for 5 days was found to possess antioxidant properties as well as hepatoprotective effects. The extract in 70% ethanol had the most potent effects with the lowest toxicity.20

Clinical data

There are no clinical data regarding the use of meadowsweet for its antioxidant properties.

Bacteriostatic effects

Bacteriostatic activity from meadowsweet flower extracts includes actions against Staphylococcus aureus, Staphylococcus epidermidis, Escherichia coli, Proteus vulgaris, and Pseudomonas aeruginosa.2 The salicylic acid in the plant is a known disinfectant used to treat ailments such as skin diseases.9 Meadowsweet is also a urinary antiseptic.8 Another study found meadowsweet to inhibit the growth of Helicobacter pylori.21 Meadowsweet did not demonstrate antiadhesive activity against Campylobacter jejuni.22

Animal data

There are no animal data regarding the use of meadowsweet to treat bacterial infections.

Clinical data

There are no clinical data regarding the use of meadowsweet to treat bacterial infections.

Cancer

Animal data

Local administration of a meadowsweet decoction resulted in a 39% decrease in the frequency of induced squamous cell carcinoma of the cervix and vagina in mice; 67% of mice had a positive response.23

Clinical data

Meadowsweet was found to exert cytotoxic effects on cultured human lymphoblastoid Raji cells.24

Miscellaneous

Meadowsweet had no effect on glycemic control when studied in mice for treatment of diabetes.25

A heparin-plant protein complex in meadowsweet was found to have anticoagulant and fibrinolytic properties.16 Meadowsweet flowers and seeds demonstrated an increased level of anticoagulant activity in vitro and in vivo in another report.26 In vitro complement inhibition from the plant's flowers has been studied.27

The tannins in the plant possess astringent properties. Root preparations have been used in the treatment of diarrhea.2, 9

Meadowsweet has been used as a sedative and to soothe nerves.9 Reduction of motor activity and potentiation of narcotic action has been observed in animals given the herb.2

Dosing

Doses of 2.5 to 3.5 g/day of flower and 4 to 5 g of herb are considered conventional; however, no clinical trials support the safety or efficacy of these dosages.3

Pregnancy / Lactation

Documented adverse effects. Uteroactivity from meadowsweet has been observed in vitro; avoid administration during pregnancy and lactation.2

Interactions

Because meadowsweet contains salicylates, it may increase the risk of bleeding when given concomitantly with antiplatelet, or anticoagulant drugs, with NSAIDs, or with any herbals with antiplatelet properties.28, 29, 30

Adverse Reactions

Meadowsweet may possibly cause GI bleeding. A case report describes a 4-year-old boy admitted with hypovolemic shock caused by severe GI bleeding. Specifically, he experienced dark stools with episodes of hematemesis the day before admission. Findings from an esophagogastroduodenoscopy revealed hiatus hernia, erosions and ulceration of the lower esophagus, and a small duodenal erosion. Two days prior to admission, he received an herbal syrup containing meadowsweet along with several other herbals for a mild cold and began bleeding that evening. The child recovered after discontinuation of the product.31 Another case report described a dog that ingested a horse supplement containing meadowsweet and willow. Following its ingestion, the dog experienced acute weakness, hematemesis, melena, a painful abdomen, and pale mucosal membranes. The supplement was speculated to be the cause of the dog's GI bleeding.32

Toxicology

The Complete German Commission E Monographs lists no known contraindications (except in people with salicylate sensitivity) for meadowsweet.3 The US Food and Drug Administration has classified the plant as an herb of undefined safety.9 Use caution because of the toxicity profile of salicylates. Methylsalicylate can be absorbed through the skin, resulting in fatalities, especially in children.2, 9 Bronchospasm has been documented with the use of the plant; therefore, use with caution in patients with asthma.

References

Disclaimer

This information relates to an herbal, vitamin, mineral or other dietary supplement. This product has not been reviewed by the FDA to determine whether it is safe or effective and is not subject to the quality standards and safety information collection standards that are applicable to most prescription drugs. This information should not be used to decide whether or not to take this product. This information does not endorse this product as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this product. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this product. This information is not specific medical advice and does not replace information you receive from your health care provider. You should talk with your health care provider for complete information about the risks and benefits of using this product.

This product may adversely interact with certain health and medical conditions, other prescription and over-the-counter drugs, foods, or other dietary supplements. This product may be unsafe when used before surgery or other medical procedures. It is important to fully inform your doctor about the herbal, vitamins, mineral or any other supplements you are taking before any kind of surgery or medical procedure. With the exception of certain products that are generally recognized as safe in normal quantities, including use of folic acid and prenatal vitamins during pregnancy, this product has not been sufficiently studied to determine whether it is safe to use during pregnancy or nursing or by persons younger than 2 years of age.

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