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Generic name: vericiguat [ VER-i-SIG-ue-at ]
Brand name: Verquvo
Dosage form: oral tablet (10 mg; 2.5 mg; 5 mg)
Drug class: Vasodilators

Medically reviewed by on Jan 19, 2024. Written by Cerner Multum.

What is vericiguat?

Vericiguat is used in certain adults with chronic heart failure, to lower the risk of death or needing to be in the hospital.

Vericiguat may also be used for purposes not listed in this medication guide.

Vericiguat side effects

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Vericiguat may cause serious side effects. Call your doctor at once if you have:

Common side effects of vericiguat may include:

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.


You should not use vericiguat if you are also using riociguat.

Vericiguat can cause birth defects. Do not use if you are pregnant. Use effective birth control while taking vericiguat and for at least 1 month after your last dose. Do not have unprotected sex.

Before taking this medicine

You should not use vericiguat if you are also using a similar medicine called riociguat.

Do not use vericiguat if you are pregnant. It could harm the unborn baby or cause birth defects. Use effective birth control to prevent pregnancy while you are using this medicine and for at least 1 month after your treatment ends. Tell your doctor right away if you miss a menstrual period or think you may have become pregnant during treatment.

You will need to have a negative pregnancy test before starting this treatment.

You should not breastfeed while using vericiguat.

How should I take vericiguat?

Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Use the medicine exactly as directed.

Take with food.

If you cannot swallow a tablet whole, you may crush the tablet and mix it with water. Swallow the mixture right away without chewing. Do not save it for later use.

Store at room temperature away from moisture and heat.

Vericiguat dosing information

Usual Adult Dose for Heart Failure:

Initial dose: 2.5 mg orally once a day
Maintenance dose: The dose should be doubled about every 2 weeks to reach the target dose of 10 mg orally once a day, as tolerated by the patient.

Use: To reduce the risk of cardiovascular death and heart failure (HF) hospitalization after a hospitalization for HF or need for outpatient IV diuretics, in patients with symptomatic chronic HF and ejection fraction less than 45%

What happens if I miss a dose?

Take the missed dose on the same day you remember it. Take your next dose at the regular time and stay on your once-daily schedule. Do not use 2 doses in one day.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while taking vericiguat?

Follow your doctor's instructions about any restrictions on food, beverages, or activity.

What other drugs will affect vericiguat?

Tell your doctor about all your other medicines, especially:

This list is not complete. Other drugs may affect vericiguat, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.

Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.