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Generic name: polatuzumab vedotinPOL-a-TOOZ-use-mab-ve-DOE-tin ]
Drug class: Miscellaneous antineoplastics

Medically reviewed by on Dec 26, 2022. Written by Cerner Multum.

What is Polivy?

Polivy is used to treat diffuse large B-cell lymphoma after at least two other cancer treatments did not work or have stopped working.

Polivy is given in combination with bendamustine (Bendeka, Treanda) and a medicine that contains rituximab (Rituxan).

Polivy may also be used for purposes not listed in this medication guide.


Polivy affects your immune system. You may get infections more easily, even serious or fatal infections. Call your doctor if you have a fever, chills, cough, mouth sores, unusual bleeding or bruising, burning when you urinate, or problems with speech, thought, or muscle movement.

Before taking this medicine

Tell your doctor if you have ever had:

  • liver disease; or

  • nerve problems (neuropathy) in your hands and feet.

Polivy can harm an unborn baby or cause birth defects if the mother or the father is using Polivy.

  • If you are a woman, you may need to have a negative pregnancy test before starting this treatment. Do not use Polivy if you are pregnant. Use effective birth control to prevent pregnancy while you are using this medicine and for at least 3 months after your last dose.

  • If you are a man, use effective birth control if your sex partner is able to get pregnant. Keep using birth control for at least 5 months after your last dose.

  • Tell your doctor right away if a pregnancy occurs while either the mother or the father is using Polivy.

This medicine may affect fertility (ability to have children) in men. However, it is important to use birth control to prevent pregnancy because Polivy can harm an unborn baby.

Do not breastfeed while using this medicine, and for at least 2 months after your last dose.

How should I take Polivy?

Polivy is given as an infusion into a vein. A healthcare provider will give you this injection.

Polivy is usually given once every 21 days, along with bendamustine and rituximab. Your doctor will determine how long to treat you with these medicines.

You may be given other medications to help prevent serious side effects, allergic reaction, or infections. Keep using these medicines for as long as your doctor has prescribed.

Polivy affects your immune system. You may get infections more easily, even serious or fatal infections. Your blood will need to be tested often, and further doses may be delayed based on the results.

What happens if I miss a dose?

Call your doctor for instructions if you miss an appointment for your Polivy.

What happens if I overdose?

Since Polivy is given by a healthcare professional in a medical setting, an overdose is unlikely to occur.

What should I avoid while taking Polivy?

Follow your doctor's instructions about any restrictions on food, beverages, or activity.

Polivy side effects

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Polivy may cause a serious brain infection that can lead to disability or death. Call your doctor right away if you have problems with speech, thought, vision, or muscle movement. These symptoms may start gradually and get worse quickly.

Some side effects may occur during the injection. Tell your caregiver if you feel feverish, chilled, itchy, light-headed, or have wheezing, chest tightness, or trouble breathing within 24 hours after the injection.

Polivy may cause serious side effects. Call your doctor at once if you have:

  • easy bruising or bleeding (nosebleeds, bleeding gums);

  • muscle weakness;

  • cough with mucus, chest pain, feeling short of breath;

  • pale skin, cold hands and feet, feeling light-headed;

  • nerve problems--numbness, tingling, pain, burning sensation in your hands or feet, weakness, trouble walking;

  • signs of infection--fever, chills, night sweats, cough, mouth sores, swollen glands, shallow breathing, pain or burning when you urinate, weight loss;

  • signs of shingles--flu-like symptoms, tingly or painful blistering rash on one side of your body;

  • liver problems--loss of appetite, stomach pain (upper right side), dark urine, jaundice (yellowing of the skin or eyes); or

  • signs of tumor cell breakdown--confusion, weakness, muscle cramps, nausea, vomiting, fast or slow heart rate, decreased urination, tingling in your hands and feet or around your mouth.

Common side effects of Polivy may include:

  • fever, cough, tiredness, or other signs of infection;

  • nerve problems; or

  • diarrhea, loss of appetite.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect Polivy?

Sometimes it is not safe to use certain medications at the same time. Some drugs can affect your blood levels of other drugs you take, which may increase side effects or make the medications less effective.

Polivy can harm your liver, especially if you also use certain medicines for infections, tuberculosis, depression, birth control, hormone replacement, high cholesterol, heart problems, high blood pressure, seizures, pain, or arthritis (including Tylenol, Advil, Motrin, or Aleve).

Other drugs may affect Polivy, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using.

Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.