Generic Name: anti-inhibitor coagulant complex (an TEE in HIB i tor koe AG yoo lant KOM plex)
Brand Name: Feiba, Feiba VH Immuno
What is Feiba (anti-inhibitor coagulant complex)?
Anti-inhibitor coagulant complex is used in people who have hemophilia and have developed antibodies to clotting factor medications.
Hemophilia, an inherited blood-clotting disorder, is often treated with medicines containing clotting factors that help control bleeding. When the body develops antibodies or "inhibitors" to the clotting factor, this treatment becomes less effective in preventing bleeding episodes. Anti-inhibitor coagulant complex works by bypassing the effects of these inhibitors to improve blood clotting and decrease the risk of bleeding.
Anti-inhibitor coagulant complex is used to treat or prevent bleeding episodes in people with hemophilia A or B who have developed inhibitors. This medicine is also used to control bleeding related to surgery in people with hemophilia and inhibitors. Anti-inhibitor coagulant complex is not for treating bleeding episodes in people who do not have inhibitors.
Anti-inhibitor coagulant complex may also be used for purposes not listed in this medication guide.
What is the most important information I should know about Feiba (anti-inhibitor coagulant complex)?
Anti-inhibitor coagulant complex may increase your risk of having a stroke or heart attack.
Call your doctor or seek emergency medical help right away if you have--sudden numbness or weakness, sudden headache, slurred speech, chest pain, trouble breathing, sudden cough with blood, warmth or swelling in your leg.
What should I discuss with my healthcare provider before using Feiba (anti-inhibitor coagulant complex)?
You should not use anti-inhibitor coagulant complex if:
you have had a severe allergic reaction to this medicine or other antihemophilic factors;
you have a blood condition called disseminated intravascular coagulation;
you have a current blood clot anywhere in your body; or
you have recently had a stroke or heart attack.
To make sure anti-inhibitor coagulant complex is safe for you, tell your doctor if you have:
coronary artery disease;
a history of heart attack, stroke, or blood clot;
a recent major injury; or
a serious infection called sepsis.
It is not known whether this medicine will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant.
It is not known whether anti-inhibitor coagulant complex passes into breast milk or if it could harm a nursing baby. Tell your doctor if you are breast-feeding a baby.
Anti-inhibitor coagulant complex is made from human plasma (part of the blood) which may contain viruses and other infectious agents. Donated plasma is tested and treated to reduce the risk of it containing infectious agents, but there is still a small possibility it could transmit disease. Talk with your doctor about the risks and benefits of using this medication.
How should I use Feiba (anti-inhibitor coagulant complex)?
Anti-inhibitor coagulant complex is injected into a vein through an IV. You may be shown how to use an IV at home. Do not give yourself this medicine if you do not understand how to use the injection and properly dispose of needles, IV tubing, and other items used.
To treat a bleeding episode, this medicine is usually given once every 6 to 12 hours until your condition improves. For routine prevention of bleeding, anti-inhibitor coagulant complex may be given every other day. Follow your doctor's dosing instructions very carefully.
If a child is using this medicine, tell your doctor if the child has any changes in weight. Anti-inhibitor coagulant complex doses are based on weight in children, and any changes may affect your child's dose.
Anti-inhibitor coagulant complex is a powder medicine that must be mixed with a liquid (diluent) before using it. If you are using the injections at home, be sure you understand how to properly mix and store the medicine.
Do not use the medicine if it has changed colors or has particles in it. Call your pharmacist for new medicine.
Use a disposable needle and syringe only once. Follow any state or local laws about throwing away used needles and syringes. Use a puncture-proof "sharps" disposal container (ask your pharmacist where to get one and how to throw it away). Keep this container out of the reach of children and pets.
Each single-use vial (bottle) of this medicine is for one use only. Throw away after one use, even if there is still some medicine left in it after injecting your dose.
Keep the medicine and diluent in their original container and store at room temperature, away from moisture, heat, and light. Do not allow the medicine to freeze.
After mixing anti-inhibitor coagulant complex with the diluent, store the mixture at room temperature and use it within 3 hours. Do not refrigerate mixed medicine.
Wear a medical alert tag or carry an ID card stating that you have hemophilia. Any doctor, dentist, or emergency medical care provider who treats you should know that you have a bleeding or blood-clotting disorder.
What happens if I miss a dose?
Call your doctor for instructions if you miss a dose of anti-inhibitor coagulant complex.
What happens if I overdose?
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.
What should I avoid while using Feiba (anti-inhibitor coagulant complex)?
Follow your doctor's instructions about any restrictions on food, beverages, or activity.
Feiba (anti-inhibitor coagulant complex) side effects
Get emergency medical help if you have signs of an allergic reaction: hives; wheezing, difficult breathing; swelling of your face, lips, tongue, or throat.
Call your doctor or seek emergency medical help right away if you have:
bruising, swelling, or pain around a joint;
heart attack symptoms--chest pain or pressure, pain spreading to your jaw or shoulder, nausea, sweating;
low red blood cells (anemia)--pale skin, feeling light-headed or short of breath, rapid heart rate, trouble concentrating;
signs of a stroke--sudden numbness or weakness (especially on one side of the body), sudden severe headache, slurred speech, problems with vision or balance;
signs of a blood clot in the lung--chest pain, sudden cough, wheezing, rapid breathing, coughing up blood or;
signs of a blood clot in your leg--pain, swelling, warmth, or redness in one or both legs.
Common side effects may include:
nausea, vomiting, diarrhea;
altered sense of taste; or
a positive hepatitis B antibody test.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
What other drugs will affect Feiba (anti-inhibitor coagulant complex)?
Tell your doctor about all your current medicines and any you start or stop using, especially:
coagulation factor VIIa;
aminocaproic acid; or
This list is not complete. Other drugs may interact with anti-inhibitor coagulant complex, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed in this medication guide.
See also: Side effects (in more detail)
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Where can I get more information?
- Your doctor or pharmacist can provide more information about anti-inhibitor coagulant complex.
- Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
- Disclaimer: Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.
Copyright 1996-2012 Cerner Multum, Inc. Version: 3.02.
Date modified: August 01, 2017
Last reviewed: March 07, 2017