Generic Name: aminocaproic acid (a MEE noe ka PROE ik AS id)
Brand Name: Amicar
What is aminocaproic acid?
Aminocaproic acid is a man-made form of a protein that occurs naturally in the body and helps the blood to clot.
Aminocaproic acid is used to treat bleeding episodes in people with certain medical conditions such as aplastic anemia (lack of blood cells and platelets), cirrhosis of the liver, placenta abruptio (early separation of the placenta in pregnancy), urinary bleeding, and certain types of cancer.
Aminocaproic acid is also used to prevent bleeding after heart surgery or placement of a shunt near the liver to control high blood pressure.
Aminocaproic acid may also be used for purposes not listed in this medication guide.
What is the most important information I should know about aminocaproic acid?
Stop using this medicine and call your doctor at once if you have: unexplained muscle pain, sudden numbness or weakness, tingling or cold feeling in an arm or leg, trouble breathing, a sudden cough or sudden chest pain.
What should I discuss with my healthcare provider before using aminocaproic acid?
You should not use aminocaproic acid if you are allergic to it.
To make sure aminocaproic acid is safe for you, tell your doctor if you have:
kidney disease; or
a history of stroke or blood clots.
It is not known whether this medicine will harm an unborn baby. Unless you are being treated for placenta abruptio, tell your doctor if you are pregnant or plan to become pregnant.
It is not known whether aminocaproic acid passes into breast milk or if it could affect the nursing baby. Tell your doctor if you are breast-feeding.
Aminocaproic acid is not approved for use by anyone younger than 18 years old.
How should I use aminocaproic acid?
Your doctor will perform blood tests to make sure you do not have conditions that would prevent you from safely using aminocaproic acid.
Follow all directions on your prescription label. Do not use this medicine in larger or smaller amounts or for longer than recommended.
Aminocaproic acid is either taken by mouth or injected into a vein through an IV.
You may be shown how to use an IV at home. Do not give yourself this medicine if you do not understand how to use the injection and properly dispose of needles, IV tubing, and other items used.
You should start using this medicine at the first sign of a bleeding episode. You may need to first use the injection form and then use an oral form (tablet or liquid). Your first dose may be much higher than the doses you use later on. Follow your doctor's dosing instructions very carefully.
Treatment with aminocaproic acid is usually continued hourly for 8 hours or until the bleeding has stopped.
Measure liquid medicine with the dosing syringe provided, or with a special dose-measuring spoon or medicine cup. If you do not have a dose-measuring device, ask your pharmacist for one.
The injectable form of aminocaproic acid must be mixed with a liquid (diluent) before using it. If you are using the injections at home, be sure you understand how to properly mix and store the medicine.
Do not use the injectable medicine if it has changed colors or has particles in it. Call your pharmacist for new medicine.
Use a disposable needle and syringe only once. Follow any state or local laws about throwing away used needles and syringes. Use a puncture-proof "sharps" disposal container (ask your pharmacist where to get one and how to throw it away). Keep this container out of the reach of children and pets.
Call your doctor promptly if your symptoms do not improve after using aminocaproic acid.
While using aminocaproic acid, you may need frequent blood tests. Your kidney function may also need to be checked. Aminocaproic acid can have long-lasting effects on your body. You may need frequent medical tests for a short time after you stop using this medicine.
Store at cool room temperature away from moisture and heat. Do not allow the medicine to freeze.
What happens if I miss a dose?
Since aminocaproic acid is used as needed, you may not be on a dosing schedule. If you are using the medication regularly, use the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not use extra medicine to make up the missed dose.
What happens if I overdose?
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.
Overdose symptoms may include urinating less than usual, feeling light-headed, or fainting.
What should I avoid while using aminocaproic acid?
Follow your doctor's instructions about any restrictions on food, beverages, or activity.
Aminocaproic acid side effects
Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.
Stop using aminocaproic acid and call your doctor at once if you have:
unexplained muscle pain or weakness (especially if you also have fever, unusual tiredness, or dark colored urine);
sudden weakness or ill feeling, fever, chills, sore throat, mouth sores, easy bruising, unusual bleeding;
numbness, tingling, or cold feeling in your arms or legs;
slow heart rate, trouble breathing, feeling like you might pass out;
kidney problems--little or no urination, painful or difficult urination, swelling in your feet or ankles, feeling tired or short of breath; or
signs of a blood clot--sudden numbness or weakness, tingling or cold feeling in an arm or leg, trouble breathing, sudden cough or chest pain, or swelling, warmth, or redness in your arms or legs.
Common side effects may include:
nausea, vomiting, stomach pain, diarrhea;
(in men) decreased amount of semen when having an orgasm;
stuffy nose, watery eyes;
vision problems, ringing in your ears; or
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Aminocaproic acid dosing information
Usual Adult Dose for Fibrinolytic Bleeding:
IV: 4 to 5 g IV infusion during the first hour of treatment, followed by a continuous infusion of 1 g/hr.
Oral: 5 g orally during the first hour of treatment, followed by a continuous rate of 1 g/hr (tablets) or 1.25 g/hr (oral solution).
Duration of therapy: Usually continued for about 8 hours or until bleeding controlled.
Use: To enhance hemostasis when fibrinolysis contributes to bleeding.
What other drugs will affect aminocaproic acid?
Tell your doctor about all your current medicines and any you start or stop using, especially:
factor IX complex; or
anti-inhibitor coagulant complex (Autoplex, Feiba VH).
This list is not complete. Other drugs may interact with aminocaproic acid, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed in this medication guide.
See also: Side effects (in more detail)
More about aminocaproic acid
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- Drug class: miscellaneous coagulation modifiers
- Aminocaproic Acid Injection Solution
- Aminocaproic Acid Oral Liquid
- Aminocaproic Acid Tablets
- Aminocaproic acid (Advanced Reading)
- Aminocaproic acid Intravenous (Advanced Reading)
Other brands: Amicar
Related treatment guides
Where can I get more information?
- Your pharmacist can provide more information about aminocaproic acid.
- Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
- Disclaimer: Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.
Copyright 1996-2012 Cerner Multum, Inc. Version: 3.02.
Last reviewed: May 09, 2017
Date modified: September 05, 2017