Emrelis

Generic name: telisotuzumab vedotin [ tel-EYE-soe-TOOZ-ue-mab-ve-DOE-tin ]
Drug class: Miscellaneous antineoplastics

Medically reviewed by Drugs.com on Jun 23, 2025. Written by Cerner Multum.

What is telisotuzumab vedotin?

Telisotuzumab vedotin is used in adults to treat non-squamous non-small cell lung cancer that has spread to other parts of the body (metastatic), or after other treatments did not work or stopped working.

Your doctor will make sure you have the correct tumor type to be treated with telisotuzumab vedotin.

Telisotuzumab vedotin may also be used for purposes not listed in this medication guide.

Telisotuzumab vedotin side effects

Get emergency medical help if you have signs of an allergic reaction: hives, difficult breathing, swelling of your face, lips, tongue, or throat.

Telisotuzumab vedotin can cause severe and life-threatening side effects. Call your doctor right away if you have numbness, tingling, muscle weakness, or burning pain in your hands or feet, blurred vision, eye pain, swelling, or redness, increased sensitivity to light, fever, cough, wheezing, or feeling short of breath.

Some side effects may occur during the injection. Tell your medical caregiver if you feel dizzy, nauseated, light-headed, itchy, sweaty, or have a headache, chest tightness, back pain, trouble breathing, or swelling in your face.

Your cancer treatments may be delayed or permanently discontinued if you have certain side effects.

Common side effects of Emrelis may include:

• loss of appetite;

• abnormal blood tests;

• nerve problems, swelling in the feet, ankles, legs or hands; or

• tired feeling.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Related/similar drugs

Warnings

Telisotuzumab vedotin can cause severe and life-threatening side effects after the injection. Call your doctor right away if you have numbness, tingling, or burning pain in your hands or feet, blurred vision, eye pain or redness, fever, cough, feeling short of breath, or you feel dizzy, nauseated, light-headed, itchy, sweaty, or have a headache.

Before taking this medicine

Tell your doctor if you have or have ever had:

• nerve problems;

• other lung or breathing problems besides lung cancer;

• eye problems; or

• liver disease.

Telisotuzumab vedotin can harm an unborn baby if the mother or the father is using this medicine.

• If you are a woman, you may need a pregnancy test to make sure you are not pregnant. Use birth control while using this medicine and for at least 2 months after your last dose.

• If you are a man, use birth control if your sex partner is able to get pregnant. Keep using birth control for at least 4 months after your last dose.

• Tell your doctor right away if a pregnancy occurs.

Do not breastfeed while using this medicine, and for at least 1 month after your last dose.

Telisotuzumab vedotin may affect fertility in men or women. Pregnancy could be harder to achieve while either parent is using this medicine.

How is telisotuzumab vedotin given?

Your doctor will perform tests to make sure telisotuzumab vedotin is the right treatment for you.

Telisotuzumab vedotin is injected into a vein by a healthcare provider once every 2 weeks. Your doctor will determine the right treatment schedule for you.

You may need frequent medical tests including vision exams, and your cancer treatments may be changed or delayed based on the results.

You will be watched for a short time to make sure you do not have an allergic reaction.

You may be given other medications to help prevent serious side effects or an allergic reaction. Keep using these medicines for as long as your doctor has prescribed.

Doses are based on weight. Your dose may change if you gain or lose weight.

What happens if I miss a dose?

Call your doctor for instructions if you miss an appointment for your telisotuzumab vedotin injection.

What happens if I overdose?

In a medical setting an overdose would be treated quickly.

What should I avoid while receiving telisotuzumab vedotin?

Follow your doctor's instructions about any restrictions on food, beverages, or activity.

What other drugs will affect telisotuzumab vedotin?

Sometimes it is not safe to use certain medicines at the same time. Some drugs can affect your blood levels of other drugs you use, which may increase side effects or make the medicines less effective.

Other drugs may affect telisotuzumab vedotin, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all other medicines you use.

Biological Products Related to Emrelis

Find detailed information on biosimilars for this medication.

Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer

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